Megacolon and Volvulus in Parkinson's Disease

Caplan, Lawrence H.; Jacobson, Harold G.; Rubinstein, Berta M.; Rotman, Marvin Z.

doi:10.1148/85.1.73

Cited by 61 publications

(28 citation statements)

References 8 publications

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“…The prevalence rate of USWs in normal subjects varies in each report (Caplan et al 1964;Wankling et al 1968). Among these published reports, the first one, by Wankling et al (1968) has an exceptionally high prevalence rate (70%) in normal subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, as shown in this study, three patients with megacolon had central nervous system disorders. The association between megacolon and disorders of the central nervous system such as Parkinson's disease (Caplan et al 1964;Kupsky et al 1987) and depression under medical treatment (Ross et al 1998) is known, but the association of USWs in such conditions has yet to be reported. The multiple presentations that have been reported may share a common physiopathology caused by hyperactivity of the internal anal sphincter presenting as high anal pressure and USWs on manometric study.…”

Section: Discussionmentioning

confidence: 99%

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Multiple Clinical Presentations of Anal Ultra Slow Waves and High Anal Pressure: Megacolon, Hemorrhoids and Constipation

Yoshino

Kayaba

Morii

et al. 2007

Tohoku J. Exp. Med.

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The physiopathology of idiopathic chronic constipation is complex and yet to be investigated. In the manometric studies of the patients with severe chronic constipation, we noticed that some patients with megacolon show very slow periodical (< 2/min) pressure change in the anal canal, namely ultra slow waves (USWs). USWs are considered to represent the hyperactivity of the internal anal sphincter; however, USWrelated clinical presentations have yet to be investigated. We retrospectively re-evaluated the patient records and manometric studies of 85 cases, 51 subjects without defecatory problems and 34 patients with constipation, to elucidate USW-related clinical presentations. USWs were seen in 10 patients, including eight patients with chronic constipation and two subjects without defecatory problems. Out of the eight patients with constipation, one had no organic change in the anorectum, three had hemorrhoids and four exhibited megacolon. Manometric and pathological studies proved that none of the four patients with magacolon was suffering from Hirschsprung's disease. Among the 51 subjects without defecatory problems, only two had USWs. Anal pressure in the USW-positive group (106.0 ± 37.0 cmH 2 O) was significantly higher than that in the group without defecatory problems (56.0 ± 27.0 cmH 2 O) or constipated patients without USWs (55.0 ± 26.0 cmH 2 O). Megacolon and high anal pressure, as well as chronic constipation and hemorrhoids, were the clinical presentations related to USWs. This is the first report to show the clinical relevance of USWs to megacolon. USWs should be recognized as an important manometric finding indicating a possible new clinical entity in chronic constipation. ultra slow wave; manometry; constipation; megacolon; high anal pressure

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multiple Clinical Presentations of Anal Ultra Slow Waves and High Anal Pressure: Megacolon, Hemorrhoids and Constipation

Yoshino

Kayaba

Morii

et al. 2007

Tohoku J. Exp. Med.

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“…Although it is not particularly remarkable that out of 28 patients one died of ileus, we nevertheless wish to refer at this point to the study by C aplan et al [2], who stresses the high incidence of megacolon -fre quently with few symptoms -in Parkinson's disease.…”

Section: Discussionmentioning

confidence: 85%

Mortality among Parkinson Patients Treated with L-Dopa Combined with a Decarboxylase Inhibitor

Zumstein¹,

Siegfried²

1976

Eur Neurol

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Since L-dopa in combination with a decarboxylase inhibitor is currently the most effective therapy available for treatment of Parkinson’s disease, the authors compare the actual causes of death in a large series of treated Parkinson patients with a normal population and with previous studies. This investigation shows that the mortality of correctly treated Parkinson patients lies within the range of the expected mortality of a group of a normal population comparable in age and sex. The risk of death for a Parkinson patient is therefore no longer higher than for the normal population.

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“…10). Acute worsening of the patient's long-standing constipation may mean obstruction by fecal impaction, but these patients are also more liable to sigmoid volvulus as the colon has chronically become dilated and elongated [100][101][102], (Fig. 11).…”

Section: Psyehoacti~e Drugsmentioning

confidence: 99%

Drug-induced gastrointestinal disease

Hyson

Burrell

Toffler

1977

Gastrointest Radiol

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The gastrointestinal tract is a common target for adverse drug reactions. The resultant changes are often nonspecific (e.g., mucosal ulceration, intestinal infarction, motility disturbance) and in many cases no radiographically detectable lesion may occur. A comprehensive review of the reported drug-induced disorders of the digestive organs is herein presented and their radiographic manifestations are described.

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Megacolon and Volvulus in Parkinson's Disease

Cited by 61 publications

References 8 publications

Multiple Clinical Presentations of Anal Ultra Slow Waves and High Anal Pressure: Megacolon, Hemorrhoids and Constipation

Multiple Clinical Presentations of Anal Ultra Slow Waves and High Anal Pressure: Megacolon, Hemorrhoids and Constipation

Mortality among Parkinson Patients Treated with L-Dopa Combined with a Decarboxylase Inhibitor

Drug-induced gastrointestinal disease

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