Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome in a Newborn After Clomiphene Ingestion During Pregnancy

Abstract

A case of megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) in a newborn after clomiphene ingestion during pregnancy is described. Review of the literature revealed no other MMIHS associated with maternal clomiphene ingestion.

Megacystis‐Microcolon‐Intestinal Hypoperistalsis Syndrome

“…A review of the literature showed that 75 cases of MMIHS have been reported to date. (1‐27,28‐54) These cases were seen in 61 female and 14 male infants (ratio 4:1). In 2 cases pregnancy was terminated after ultrasonography detected the syndrome, which was confirmed at autopsy in both cases (34,36).…”

“…The maternal age ranged from 18 to 36 years (mean 27 years). In 2 patients, exposure to drugs (clomiphene [31], scopolamine, trimethoprim‐sulfadiazine, and dypirone [41]) during the first weeks of gestation was reported.…”

Variants of Hirschsprung's Disease

“…Hastalığın 1976 yılında tanımlanmasından sonra patogenezinin açıklanması için, genetik, nörojenik, miyojenik, hormonal ve toksik teoriler ortaya atılmıştır (2,(13)(14)(15)(16)(17) . Puri ve ark.…”

“…En sık rastlanan bulgu prenatal ultrasonografide (USG) büyümüş mesane ve hidronefrozdur (2,13) . Kli- nik tablo diğer bütün ağır yenidoğan bağırsak tıkanıklıkları tabloları ile benzerlik gösterir.…”