Megahertz streak-mode Fourier domain optical coherence tomography

Wang, Rui; Yun, Julie X.; Yuan, Xiaocong; Goodwin, Richard L.; Markwald, Roger R.; Gao, Bruce Z.

doi:10.1117/1.3593149

Cited by 16 publications

(15 citation statements)

References 18 publications

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“…Utilizing a high-speed area-scan camera together with a streak scanner, the imaging speed of the SD-OCT can be boosted up to ~1 MHz, but in streak-mode [49]. Another SD-OCT system based on optical demultiplexers has demonstrated an A-scan rate as fast as 60 MHz with a good sensitivity of 88 dB [22].…”

Section: Discussionmentioning

confidence: 99%

“…6): sensitivity, A-scan rate, and axial spatial resolution [7,17,[20][21][22][23][24][25][26][27][28][29][30][48][49][50]. Each circle represents each OCT system whereas the size of the circle represents the resolution, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…As S shot is a function of P s , we colorcode the curves S shot for a range of P s values from −4 dBm to 16 dBm which covers the power range in all the chosen cases, i.e. ref [7,17,[20][21][22][23][24][25][26][27][28][29][30][48][49][50]. Note that individual circles are filled with the same color code to represent the adopted optical power P s such that their performance can be compared to the corresponding shot-noise limits in the same plot.…”

Section: Discussionmentioning

confidence: 99%

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High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch

Xu¹,

Wei²,

Yu³

et al. 2015

Biomed. Opt. Express

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Abstract:As the key prerequisite of high-speed volumetric structural and functional tissue imaging in real-time, scaling the A-scan rate beyond MHz has been one of the major pursuits in the development of optical coherence tomography (OCT). Along with a handful of techniques enabling multiMHz, amplified optical time-stretch OCT (AOT-OCT) has recently been demonstrated as a viable alternative for ultrafast swept-source OCT well above MHz without the need for the mechanical wavelength-tuning mechanism. In this paper, we report a new generation of AOT-OCT demonstrating superior performance to its older generation and all other time-stretch-based OCT modalities in terms of shot-to-shot stability, sensitivity (~90dB), roll-off performance (>4 mm/dB) and A-scan rate (11.5 MHz). Such performance is mainly attributed to the combined contribution from the stable operation of the broadband and compact mode-locked fiber laser as well as the optical amplification in-line with the time-stretch process. The system allows us, for the first time, to deliver volumetric timestretch-based OCT of biological tissues with the single-shot A-scan rate beyond 10 MHz. Comparing with the existing high-speed OCT systems, the inertia-free AOT-OCT shows promises to realize high-performance 3D OCT imaging at video rate. "Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging," Opt. Lett. 39(23), 6593-6596 (2014). 37. T. T.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch

Xu¹,

Wei²,

Yu³

et al. 2015

Biomed. Opt. Express

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“…Hence, they are much more prone to motion artifacts as very slow OCT systems, although numerical correction schemes exist [163]. Streak mode OCT also uses a 2D camera, but maintains confocal scanning by recording the spectrum in streak mode, demonstrated at up to 2 MHz [164]. However, the prolonged integration time induces a larger SNR drop when samples are measured with axial or transverse motion.…”

Section: Line-field and Full-field Octmentioning

confidence: 99%

High-speed OCT light sources and systems [Invited]

Klein¹,

Huber²

2017

Biomed. Opt. Express

201

111

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Abstract:Imaging speed is one of the most important parameters that define the performance of optical coherence tomography (OCT) systems. During the last two decades, OCT speed has increased by over three orders of magnitude. New developments in wavelength-swept lasers have repeatedly been crucial for this development. In this review, we discuss the historical evolution and current state of the art of high-speed OCT systems, with focus on wavelength swept light sources and swept source OCT systems. 3067-3086 (2012). 7. J. Xu, X. Wei, L. Yu, C. Zhang, J. Xu, K. K. Y. Wong, and K. K. Tsia, "High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch," Biomed. Opt. Express 6(4), 1340-1350 (2015). 8. D. J. Fechtig, B. Grajciar, T. Schmoll, C. Blatter, R. M. Werkmeister, W. Drexler, and R. A. Leitgeb, "Line-field parallel swept source MHz OCT for structural and functional retinal imaging," Biomed. Opt. Express 6(3), 716-735 (2015). 9. T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, "Multi-MHz retinal OCT," Biomed.Opt. Express 4(10), 1890-1908 (2013). 10. E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, "High-speed optical coherence domain reflectometry," Opt. Lett. 17(2), 151-153 (1992). 11. G. J. Tearney, B. E. Bouma, S. A. Boppart, B. Golubovic, E. A. Swanson, and J. G. Fujimoto, "Rapid acquisition of in vivo biological images by use of optical coherence tomography," Opt. Lett. 21(17), 1408-1410 (1996). 12. G. J. Tearney, B. E. Bouma, and J. G. Fujimoto, "High-speed phase-and group-delay scanning with a gratingbased phase control delay line," Opt. Lett. 22(23), 1811-1813 (1997). 13. A. Rollins, S. Yazdanfar, M. Kulkarni, R. Ung-Arunyawee, and J. Izatt, "In vivo video rate optical coherence tomography," Opt. Express 3(6), 219-229 (1998). 14. G. Häusler and M. W. Lindner, "Coherence radar and 'spectral radar'-new tools for dermatological diagnosis," J.Biomed. Opt. 3(1), 21-31 (1998). 15. B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, "Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser," Opt. Lett. 22(22), 1704-1706 (1997). 16. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22(5), 340-342 (1997). 17. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7(3), 457-463 (2002). 18. L. Kranendonk, R. Bartula, and S. Sanders, "Modeless operation of a wavelength-agile laser by high-speed cavity length changes," Opt. Express 13(5), 1498-1507 (2005). 656-664 (2012). 36. C. Henry, "Theory of the linewidth of semiconductor lasers," IEEE J. Quantum Electron. 18(2), 259-264 (1982). 37. J. Geng, Q. Wang, J. Wang, S. Jiang, and K. Hsu, "All-fiber wavelength-swept laser near 2 μm," Opt. Lett. 3771-3773 (2011). 38. F. Nielsen, L. Thrane, J. Black, A. Bjarklev, and P. Ander...

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“…1 Nowadays, there is an increasing need for volumetric imaging in real time, resulting in the demand for higher imaging speed. [2][3][4][5] Swept-source OCT (SS-OCT) is an attractive and practical modality enabling an ultrahigh-speed A-scan rate. The Fourier domain mode locked laser and the microelectromechanical systems tunable vertical cavity surface-emitting laser have been developed as new light sources for SS-OCT enable high imaging speeds of up to 1 to 20 MHz.…”

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confidence: 99%

Ultrahigh-speed optical coherence tomography utilizing all-optical 40 MHz swept-source

et al. 2015

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Megahertz streak-mode Fourier domain optical coherence tomography

Abstract: Abstract.Here we present an ultrahigh-speed Fourier-domain optical coherence tomography (OCT) that records the OCT spectrum in streak mode with a high-speed area scan camera, which allows higher OCT imaging speed than can be achieved with a line-scan camera.

Cited by 16 publications

References 18 publications

High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch

High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch

High-speed OCT light sources and systems [Invited]

Ultrahigh-speed optical coherence tomography utilizing all-optical 40 MHz swept-source

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