Megakaryocytes and Platelet Clumps as the Cause of Finger Clubbing

Dickinson, C. J.; Martin, J. F.

doi:10.1016/s0140-6736(87)91132-9

Cited by 159 publications

(83 citation statements)

References 15 publications

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“…It is believed to be stimulated by platelet-derived growth factor (PDGF) which leads to the proliferation of connective tissue. [14] Several mechanisms have been proposed by which platelet clumps accumulate in the fingertips and release PDGF. Hepatocyte growth factor is another potential stimulator of clubbing.…”

Section: Discussionmentioning

confidence: 99%

A Takayasu's Arteritis Case with Unilateral Digital Clubbing

et al. 2011

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Takayasu arteriti genellikle yaşamın ikinci ve üçüncü on yılında genç kadınları etkileyen bir büyük damar vaskülitidir. Daha az sıklıkta çocukluk çağında da görülebilir. Bu yazıda tek taraflı çomak parmağı olan Takayasu arteritli 17 yaşındaki bir erkek olgu sunuldu. Hastanın sol üst ve alt ekstremitelerinde bir aydan beri devam eden kas zayıflığı ve miyaljisi vardı. Hipertansiyon ve abdominal üfürüm yoktu. Dijital subtraksiyon anjiyografide sol subklaviyan arterde total tıkanma ve sağ renal arterde ciddi daralma olduğu görüldü. Çomak parmak ve Takayasu arteriti birlikteliği yaygın değildir. Bilgilerimize göre bugüne kadar yalnız iki olgunun sunumu yapılmıştır.Anahtar sözcükler: Çomak parmak; dijital subtraksiyon anjiyografi; hipertansiyon; Takayasu arteriti.Takayasu arteritis is a large vessel vasculitis that usually affects young female patients during the second and third decades of life. Less commonly, it can also be seen childhood. In this article, we describe a case of Takayasu arteritis in a 17 year-old-boy who presented with unilateral digital clubbing. The patient had also a one-month history of muscle weakness and myalgia in the left upper and lower extremity. There was no hypertension or abdominal bruit. Digital subtraction angiography revealed a total occlusion of the left subclavian artery and a severe narrowing of the right renal artery. The association of digital clubbing and Takayasuʼs arteritis is not common. To our knowledge, only two cases have been reported to date.

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Section: Discussionmentioning

confidence: 99%

A Takayasu's Arteritis Case with Unilateral Digital Clubbing

et al. 2011

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“…This factor has been shown to have general growth-promoting activity and causes increased capillary permeability and connective tissue hypertrophy. 2 …”

Section: Pathophysiologymentioning

confidence: 99%

Untitled

2017

Ind J Car Dis Wom

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“…Although the exact mechanism of HOA remains unclear, several theories have been proposed [237,238,242] . The most promising explanation involves megakaryocytes and platelet clumps.…”

Section: Hypertrophic Pulmonary Osteoarthropathymentioning

confidence: 99%

“…The most promising explanation involves megakaryocytes and platelet clumps. Megakaryocytes continually emerge from the bone marrow; they are trapped by the pulmonary capillary bed and fragment there into platelets [242] . In disorders in which megakaryocytes or megakaryocyte fragments bypass the pulmonary capillary network, these large particles can enter the systemic circulation and reach the fingertips in axial vascular streams [237,242] .…”

Section: Hypertrophic Pulmonary Osteoarthropathymentioning

confidence: 99%

“…Megakaryocytes continually emerge from the bone marrow; they are trapped by the pulmonary capillary bed and fragment there into platelets [242] . In disorders in which megakaryocytes or megakaryocyte fragments bypass the pulmonary capillary network, these large particles can enter the systemic circulation and reach the fingertips in axial vascular streams [237,242] . These large megakaryocyte fragments then interact with endothelial cells, leading to the release of growth factors, including platelet-derived growth factor (PDGF), prostaglandin E, and vascular endothelial growth factor (VEGF) [238] .…”

Section: Hypertrophic Pulmonary Osteoarthropathymentioning

confidence: 99%

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Paraneoplastic syndromes associated with lung cancer

1993

Lung Cancer

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Paraneoplastic syndromes are signs or symptoms that occur as a result of organ or tissue damage at locations remote from the site of the primary tumor or metastases. Paraneoplastic syndromes associated with lung cancer can impair various organ functions and include neurologic, endocrine, dermatologic, rheumatologic, hematologic, and ophthalmological syndromes, as well as glomerulopathy and coagulopathy (Trousseau's syndrome). The histological type of lung cancer is generally dependent on the associated syndrome, the two most common of which are humoral hypercalcemia of malignancy in squamous cell carcinoma and the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer. The symptoms often precede the diagnosis of the associated lung cancer, especially when the symptoms are neurologic or dermatologic. The proposed mechanisms of paraneoplastic processes include the aberrant release of humoral mediators, such as hormones and hormone-like peptides, cytokines, and antibodies. Treating the underlying cancer is generally the most effective therapy for paraneoplastic syndromes, and treatment soon after symptom onset appears to offer the best potential for symptom improvement. In this article, we review the diagnosis, potential mechanisms, and treatments of a wide variety of paraneoplastic syndromes associated with lung cancer.

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Megakaryocytes and Platelet Clumps as the Cause of Finger Clubbing

Cited by 159 publications

References 15 publications

A Takayasu's Arteritis Case with Unilateral Digital Clubbing

A Takayasu's Arteritis Case with Unilateral Digital Clubbing

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Paraneoplastic syndromes associated with lung cancer

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