Megakaryocytes and Platelets in the Spleen of the Dromedary Camel (<i>Camelus dromedarius</i>)

Zidan, Mohamed; Kassem, Anwar; Pabst, Reinhard

doi:10.1046/j.1439-0264.2000.00268.x

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…This indicates that the bat's spleen has little or no role in thrombopoiesis. Megakaryocyte is normally found in the high number in the spleen as reported in cats, dogs, rats, mice, camels and leopard seals (Gray et al, ; Rothermel, ; Ward et al, ; Zidan, Kassem, & Pabst, ). The absence of megakaryocyte is also observed in the Cape fur seal spleen (Stewardson, Hemsley, Meyer, Canfield, & Maindonald, ) and African palm squirrel (Ekele & Niebedum, ).…”

Section: Discussionmentioning

confidence: 93%

The spleen morphophysiology of fruit bats

Hanadhita

Rahma

Prawira

et al. 2019

Anat Histol Embryol

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Spleen is one of the important lymphoid organs with wide variations of morphological and physiological functions according to species. Morphology and function of the spleen in bats, which are hosts to several viral strains without exhibiting clinical symptoms, remain to be fully elucidated. This study aims to examine the spleen morphology of fruit bats associated with their physiological functions. Spleen histological observations were performed in three fruit bats species: Cynopterus titthaecheilus (n = 9), Rousettus leschenaultii (n = 3) and Pteropus vampyrus (n = 3). The spleens of these fruit bats were surrounded by a thin capsule. Red pulp consisted of splenic cord and wide vascular space filled with blood. Ellipsoids in all three studied species were found numerously and adjacent to one another forming macrophages aggregates. White pulp consisted of periarteriolar lymphoid sheaths (PALS), lymphoid follicles and marginal zone. The lymphoid follicle contained a germinal centre and a tingible body macrophage that might reflect an active immune system. The marginal zone was prominent and well developed. This study reports some differences in spleen structure of fruit bats compared to other bat species previously reported and discusses possible physiological implications of the spleen based on its morphology. K E Y W O R D S flying foxes, histology, immunology, morphology, physiology, viral reservoir

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Section: Discussionmentioning

confidence: 93%

The spleen morphophysiology of fruit bats

Hanadhita

Rahma

Prawira

et al. 2019

Anat Histol Embryol

View full text Add to dashboard Cite

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“…careful search of the literature failed to identify any detailed study on the morphology of camel platelets.'' This is not true because two previous studies, by Lewis [2] and Zidan et al [3] provide significant details with ample number of micrographs on this very topic and most of their findings were more or less mirrored in the recent paper. In this age of easily accessible information, a ''careful search'' using Google, let alone PubMed, could not have missed these earlier references, especially when there is a paucity of published work on this topic.…”

Section: Letter To the Editor Ultra Structure Of Camel Plateletsmentioning

confidence: 95%

Ultra Structure of Camel Platelets

Majeed¹

2009

Platelets

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Physiology of aging among healthy, older bottlenose dolphins (Tursiops truncatus): comparisons with aging humans

et al. 2011

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Changes in hematological and serum chemistry values have been identified among older compared to younger humans. We hypothesized that healthy bottlenose dolphins (Tursiops truncatus) 30 years and older may demonstrate similar clinicopathological changes with increasing age. Retrospective hematological and serum chemistry data generated from routine, fasted blood samples collected over 10 to 20 years among six healthy dolphins that lived at least 40 years were analyzed to (1) assess linear trends in blood variable values with increasing age, (2) compare mean blood values by older age categories (30-35 years, 36-40 years, and >40 years), and (3) compare the prevalence of clinically high or low blood values by older age categories. Absolute lymphocytes, serum globulins, and mean platelet volume increased linearly with increasing old age. Mean white blood cells, neutrophils, serum globulins, erythrocyte sedimentation rates, serum cholesterol, and serum triglycerides; and the prevalence of neutrophilic leukocytosis, hyperglobulinemia, and hypercholesterolemia, were more likely to be higher as geriatric dolphins got older. A linear decrease in serum albumin with increasing age was present for five of six animals. Serum creatinine decreased among dolphins older than 40 years compared to when they were 30-40 years old. Our study demonstrates that older dolphins have changes in hematological and serum chemistry values similar to those found in older humans. As such, bottlenose dolphins may serve as a useful comparative model for aging in humans. Further studies are needed to assess whether these changes are associated with negative health outcomes and whether targeted therapeutics can help improve quality of life among aging dolphins.

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Megakaryocytes and Platelets in the Spleen of the Dromedary Camel (Camelus dromedarius)

Cited by 7 publications

References 8 publications

The spleen morphophysiology of fruit bats

The spleen morphophysiology of fruit bats

Ultra Structure of Camel Platelets

Physiology of aging among healthy, older bottlenose dolphins (Tursiops truncatus): comparisons with aging humans

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