Megakaryocytes in pleural and peritoneal fluids: prevalence, significance, morphology, and cytohistological correlation.

Abstract

SUMMARY Over a period of 22 years, 4844 pleural and peritoneal fluids from 3279 patients were examined cytologically. Megakaryocytes were found in the fluids from five patients. The clinical diagnoses in the five patients were agnogenic myeloid metaplasia, chronic myeloid leukaemia, and lymphocytic lymphoma. All of these patients had persistent serous effusions. Megakaryocytes in serous fluids occurred in three forms: (1) a large type with abundant cytoplasm and multilobed nuclei, (2) a smaller type with a high nucleocytoplasmic ratio and unlobed nuclei, and (3)

Idiopathic Myelofibrosis with Refractory Massive Ascites

“…Kumar and Naylor (6) reported that the pleural or peritoneal fluid from 5 out of 3,279 patients contained megakaryocytes, and three of them were IMpatients. Twoof the patients underwent autopsies, and the foci of ectopic hematopiesis was found on the serous surface (1 1).…”

Extramedullary Hematopoietic Pleural Effusion Accompanied by Follicular Lymphoma

“…On the other hand, two large retrospective analyses of EHE revealed the most common primary diseases associated with EHE to be myelofibrosis (1) and lung cancer (2). Reports of EHE accompanied by malignant lymphoma have been limited thus far and lack detailed clinical data (1,2). We herein report a case of EHE accompanied by follicular lymphoma (FL).…”

“…Extramedullary hematopoietic effusion (EHE), including pleural, peritoneal and pericardial effusion, is widely accepted to be a rare manifestation accompanied by hematologic disorders and neoplastic diseases (1)(2)(3)(4)(5). Due to its rarity, most reports are case reports.…”

Agnogenic Myeloid Metaplasia Presenting as Massive Pericardial Effusion due to Extramedullary Hematopoiesis

“…The finding of extramedullary hematopoiesis in the serosa surfaces has seldom been reported [1][2][3]5], but may be associated with marked and persistent ef fusion [1,2,[6][7][8].…”