Megaloblastic Anaemia of Infancy in Kwashiorkor and Other Diseases

Kwashiorkor

“…Bone-marrow studies generally revealed a normoblastic (Trowell et al, 1954) or a macronormoblastic (Woodruff, 1955) haemopoiesis. Other workers (Mehta and Gopalan, 1956;Walt et al, 1956Walt et al, , 1957 found a high incidence of megaloblastic anaemia. In our experience iron deficiency or a megaloblastic anaemia is rare in kwashiorkor.…”

Serum and red cell folates, and serum vitamin B12 in protein calorie malnutrition

“…In Durban, Walt, Holman, and Hendrickse (1956) reported megaloblastosis in 100% of their kwashiorkor cases, while Adams et al (1967) in the same town found megaloblastic erythropoiesis in only 28% of cases. Sandstead et al (1965) in Cairo reported an incidence of 35 %.…”

Vitamin B12 and Megaloblastic Anaemias in South African Bantu

“…Of the forms of anaemia described in this ethnic group, megaloblastic anaemia occurs particularly in association with pregnancy (Adams and Wilmot, 1953;Metz, 1960) and in malnourished infants (Altmann and Murray, 1948;Walt et al, 1956;Shnier and Metz, 1959). Addisonian pernicious anaemia, while less frequent than in white populations, also occurs (Woods and Rymer, 1955;Adams, 1957;Metz et al, 1958).…”