Megaloblastic Anemia Associated with Long-Term Tetracycline Therapy

Jones, Carroll C.

doi:10.7326/0003-4819-78-6-910

Cited by 13 publications

(3 citation statements)

References 3 publications

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“…These byproducts have several deleterious biological effects and are known as high-affinity ligands for the Tet repressor protein that up regulates antibiotic efflux resistance mechanisms. [28][29][30] Further, the C4 dimethylamino group can undergo a reversible epimerization process in vitro and in vivo, producing a set of epimers with different antibacterial activities (Fig. 3).…”

Section: Cross-reactivity Of Elisamentioning

confidence: 99%

Application of ELISA in determining the fate of tetracyclines in land-applied livestock wastes

Aga

Goldfish

Kulshrestha

2003

Analyst

149

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The potential use of a class-specific enzyme-linked immunosorbent assay (ELISA) in studying the occurrence and fate of tetracyclines in the environment was evaluated. Several manure samples collected from hog lagoons and cattle feedlots were screened for the presence of tetracycline residues using ELISA. The levels varied from less than the detection limit (0.5 parts per billion) to 200 parts per million. The degradation of tetracyclines in soil-applied manure was followed using ELISA to measure the decline in tetracycline concentrations. Low levels of tetracyclines remained detectable in soil for up to 28 days. The ELISA procedure also proved useful in determining the leaching potential of tetracyclines in undisturbed soil columns and in the analysis of total tetracyclines in manure, soil, and water. Based on the cross-reactivity of the antibodies employed, this ELISA method can be an important screening tool for the presence of other tetracycline compounds, such as chlortetracycline and oxytetracycline. The ELISA method also detects the epimers of tetracyclines and the corresponding dehydration by-products, anhydrotetracyclines. Analysis of selected manure extracts by liquid chromatography with mass spectrometry (LC-MS) showed lower concentrations of total tetracyclines compared to the values obtained by ELISA, indicating the presence of other structurally related compounds or transformation products of tetracyclines being detected by ELISA in the samples. Because analysis of manure and soil samples by LC-MS requires extensive clean-up procedures, ELISA provides an alternative method for conducting environmental fate and transport studies of antibiotics.

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Section: Cross-reactivity Of Elisamentioning

confidence: 99%

Application of ELISA in determining the fate of tetracyclines in land-applied livestock wastes

Aga

Goldfish

Kulshrestha

2003

Analyst

149

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“…The tetracycline family has been implicated as a cause of anemia. There are several reports of tetracycline-induced aplastic anemia [2], megaloblastic anemia [3], and hemolytic anemia [4][5][6][7][8]. Oxytetracycline has been associated with aplastic anemia [8] while another derivative minocycline has been implicated in hemolytic anemia [9].…”

Section: Discussionmentioning

confidence: 99%

Reversible sideroblastic anemia associated with the tetracycline analogue COL‐3

et al. 2001

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“…The malabsorption in our pa tients proved to be tetracycline-responsive. Of interest is the recently described mega loblastic anemia following long-term tetra cycline therapy for acne [11]. Although this has not been yet appreciated, such a poten tial complication should be considered dur ing the management of the malabsorption of scleroderma.…”

Section: Discussionmentioning

confidence: 99%

Hematological Abnormalities in Scleroderma

Frayha¹,

Shulman²,

Stevens³

1980

Acta Haematol

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Hematological abnormalities in scleroderma indicate a specific complication of the disease itself, or an associated illness. Among 180 patients with scleroderma, anemia was detected in 25% and was attributed to chronic inflammatory disease (usually an overlap syndrome), bleeding mucosal telangiectases as part of the CREST syndrome, intestinal malabsorption, and microangiopathic hemolysis. Leukocytosis, present in 14%, was correlated with active myopathy and/or advanced visceral involvement while leukopenia was suggestive of a crossover with systemic lupus erythematosus. Thrombocytopenia was often a manifestation of microangiopathy, and thrombocytosis was associated with an arteritis or a tumor syndrome.

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Megaloblastic Anemia Associated with Long-Term Tetracycline Therapy

Cited by 13 publications

References 3 publications

Application of ELISA in determining the fate of tetracyclines in land-applied livestock wastes

Application of ELISA in determining the fate of tetracyclines in land-applied livestock wastes

Reversible sideroblastic anemia associated with the tetracycline analogue COL‐3

Hematological Abnormalities in Scleroderma

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