Megaloblastic anemia: Back in focus

Chandra, Jagdish

doi:10.1007/s12098-010-0121-2

Cited by 28 publications

(31 citation statements)

References 23 publications

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“…Se encuentra en alimentos como las verduras de hoja verde, legumbres, frutos secos y granos enteros como las almendras [2]. El ácido fólico es de particular interés clínico por su relación con la anemia megaloblástica y diversos trastornos neurológicos relacionados con la carencia de la vitamina [3,4], suplencia perinatal y prevención de defectos del tubo neural [5], metabolismo de la homocisteína y su asociación con eventos vasculares cardiacos y cerebrales [6] y su relación con la disminución del riesgo a padecer diversos tipos de cáncer [7].…”

Section: Introductionunclassified

Valores séricos de ácido fólico en un grupo de pacientes mayores de 18 años de edad en un hospital de alta complejidad

et al. 2017

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ResumenObjetivo: establecer las concentraciones séricas de ácido fólico en un grupo de pacientes adultos. Métodos: medición del ácido fólico con inmunoanálisis en 1797 sujetos. Se calcularon medidas de tendencia central e índice de confianza al 95 %. Se compararon grupos etarios y sexos con pruebas no paramétricas. Resultados: la media global de ácido fólico sérico fue: 11,61 ng/ml (DE: 6,05). La media en mujeres fue de 11,87 ng/ml (DE: 6,09). La media en hombres fue de 11,31 ng/ml (DE: 6). Se reportaron los percentiles 5, 50 y 95 por sexo y edad. En el 2 % de los casos se encontró ácido fólico < 2 ng/ml (2 % de hombres y 3 % de mujeres). Discusión: las concentraciones séricas de ácido fólico son mayores en mujeres que en hombres (p = 0,024), lo que contrasta con la noción de déficit del micronutriente en el sexo femenino. Conclusiones: las cantidades descritas son un comparador adecuado para mediciones en muestras de población general.

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Section: Introductionunclassified

Valores séricos de ácido fólico en un grupo de pacientes mayores de 18 años de edad en un hospital de alta complejidad

et al. 2017

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“…It has been reported that 5-mg daily dose of folic acid is not associated with adverse effects and is used as replacement therapy for treatment of megaloblastic anemia [5].…”

Section: Clinical Relevance and Therapeutic Benefits Of Folic Acidmentioning

confidence: 99%

Indian Perspective on Clinical Aspects, Usage, and Guidelines of Folic Acid

Paayal¹,

Ganesh²,

Shaantanu

2014

J Obstet Gynecol India

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Folic acid (pteroylmonoglutamic acid) is the stable, fully oxidized form of folate which is used in food fortification and supplements. Keen interest has been generated in folic acid due to its suggested role in prevention of various disorders. Strong evidence from clinical trials indicates preventive effect of folic acid on both occurrence and recurrence of neural tube defects. It also plays a significant role in mitigating the risk of cardiovascular disorders through homocysteine regulation. In addition, the beneficial effect of folic acid in various types of cancers, neurological disorders, conditions affecting pregnancy, and other clinical conditions has been reported in literature. Various guidelines reinforce the need for women to obtain adequate amount of folic acid either through food fortification or supplements. In India, national guidelines on the proper dose of folic acid to pregnant women are not available. Given its significant beneficial effects on health, awareness should be spread among communities on the usage and benefits of folic acid.

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“…Unfortunately, from public health view point, deficiency of B12 / folate has been regarded to contribute little to nutritional anemia 4 . Various workers have brought this to the forefront but in vain.…”

Section: Introductionmentioning

confidence: 99%

A study on prevalence and causative factors of megaloblastic anaemia in Hadoti region.

Agarwal

Ramawat

Agrawala³

et al. 2017

AABS

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Background: Anaemia is the most common problems encountered by clinicians in Hadoti Region. The affected population includes male, female as well as children. Over the last two decades, it has been found that incidence of megaloblastic anaemia is increasing. Folic Acid and Vitamin B12 deficiency are the most common cause of megaloblastic anemia. Of these two micronutrients, Vitamin B12 deficiency is more common now, due to vegetarian life style of people. At present, Anemia control or prophylaxis program give only Iron and Folic acid. This study has been chosen to focus on this issue. The cases for increasing incidences of Folate / Vit. B12 deficiency needs to be elucidated.Objectives: To focus on the incidence of megaloblastic anaemia in Hadoti Region. & Probable Causative factors will be analysed Methods: All patients presenting to our hospital over a period of 2 months with a haemoglobin <10 g/dl and peripheral smear findings consistent with megaloblastic anaemia will be included in the study. Diet, drug intake, previous blood transfusion, presenting symptoms and other relevant history will be taken into consideration. Complete blood counts, peripheral film examination, reticulocyte count and cobalamin and folate assays will be recorded. Patients with chronic disease like renal disease, cancer, tuberculosis, liver disease etc will be excluded from the study. All data will be collected and evaluated statistically. Result:In the present study, total 500 patients who were admitted in medicine, paediatric and gynaecology ward were evaluated. All these patients met the inclusion criteria. Depending on the MCV value, serum assay and peripheral smear finding, they were categorised into 3 groups-Macrocytic, normocytic and microcytic anaemia. The normal MCV value but with megaloblastic blood film or low serum markers were considered into macrocytic anaemia. Total 100 patients were diagnosed as macrocytic anaemia. The sex distribution were-70(male), 30(female). Fifty five per cent of patients with cobalamin deficiency and 08% of patients with folate deficiency were found. All the patients were vegetarian and from middle class and low socio economic group. Conclusion:Cobalamin deficiency was responsible for megaloblastic anaemia in the majority of our patients. The supplementation program for Anemia control and prophylaxis should vary according to the regional requirements. Vitamin B12 should be included in the nutritional programme along with iron and folic acid. Awareness camp and Education program about megaloblastic anemia can be implemented for the prevention.

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Megaloblastic anemia: Back in focus

Cited by 28 publications

References 23 publications

Valores séricos de ácido fólico en un grupo de pacientes mayores de 18 años de edad en un hospital de alta complejidad

Valores séricos de ácido fólico en un grupo de pacientes mayores de 18 años de edad en un hospital de alta complejidad

Indian Perspective on Clinical Aspects, Usage, and Guidelines of Folic Acid

A study on prevalence and causative factors of megaloblastic anaemia in Hadoti region.

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