Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B12 Metabolism: Case Reports and Literature Review

Mullikin, Dolores; Pillai, Nishitha R.; Sánchez, Rubén; O’Donnell-Luria, Anne; Kritzer, Amy; Tal, Leyat; Almannai, Mohammed; Berry, Gerard T.; Gambello, Michael J.; Li, Hong; Graham, Brett H.; Srivaths, Lakshmi; Sutton, V. Reid; Grimes, Amanda

doi:10.1016/j.jpeds.2018.06.054

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…And some diseases are inevitable with the continued lack of certain vitamins. For example, the vitamin A deficiency is often responsible for night blindness (Cruz et al, 2018); the vitamin B12 deficiency can cause metabolic disorders (Mullikin et al, 2018); and the vitamin D deficiency can lead not only to rickets but may also be associated with diabetes mellitus (de Oliveira & Domingueti, 2018;Abdi et al, 2019). Lin et al (Lin et al, 2016) studied the inhibitory effects of vitamin B2 and D3 on xanthine oxidase (XO), between which was a synergistic effect.…”

Section: Vitaminsmentioning

confidence: 99%

Recent developments in molecular docking technology applied in food science: a review

Tao

Huang

Wang

et al. 2019

Int J of Food Sci Tech

150

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Molecular docking is a theoretical simulation method based on bioinformatics, which studies the interaction between molecules (such as ligands and receptors), and predicts their binding modes and affinity via a computer platform. This technology acts as a promising mean in medicinal chemistry such as structurebased rational drug design, which is accepted by researchers in the scientific community. During recent years, various fundamental studies involving biomolecular interaction in the food matrix have gradually emerged. The remarkable advantages of molecular docking such as predicting experiments are attracting increasing attention for its application potential in various fields. This review presents the theory and software development of molecular docking, and emphasises its application in the field of food science, including nutritional components and food safety. Moreover, the operational mechanisms of molecular docking are further summarised in this review.

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