Megaloblastic Crisis in Paroxysmal Nocturnal Hemoglobinuria

Pavlic, G.; Bouroncle, Bertha A.

doi:10.1056/nejm196510072731504

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…Their extent seems to indicate that both intramedullary and peripheral haemolysis play a role in the production of the anaemia. Since the requirement for folic acid rises sharply in haemolytic conditions associated with chronic hyperactivity of the bone marrow (Chanarin et a1 1959, Jandl & Greenberg 1959, Delamore et al 1961, Lindenbaum & Klipstein 1963, Pearson & Cobb 1964, Komminos et a1 1965, Pavlic & Bouroncle 1965, fl-thalassaemia heterozygotes should demonstrate some degree of folate-deficiency .…”

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confidence: 99%

Folic Acid Deficiency in β‐Thalassaemia Heterozygotes

Castaldi

Bagni

Trotta

et al. 1983

Scandinavian Journal of Haematology

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Plasma and red cell folate mean contents have been found to be significantly lower in 41 symptom-free P-thalassaemia heterozygotes than in 21 controls. Such decreases must be considered as effects of an increased folate utilization caused by the enhanced total, both effective and ineffective, erythropoiesis. Since no close correlation has been found between packed cell volume and plasma or red blood cell folate levels, it seems that in 'healthy' P-thalassaemia subjects, the degree of anaemia is not influenced by folate body reserves. However, the frequent finding of reduced red cell folate contents suggests that further folate imbalance might lead to clinically significant degrees of folate deficiency.

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confidence: 99%