Megavoltage irradiation in the treatment of gliomas of the brain and spinal cord

Marsa, Gerald W.; Goffinet, Don R.; Rubinstein, Lucien J.; Bagshaw, Malcolm A.

doi:10.1002/1097-0142(197511)36:5<1681::aid-cncr2820360523>3.0.co;2-z

Cited by 96 publications

(12 citation statements)

References 11 publications

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“…A progression to astrocytoma grade III or glioblastoma occurred in 39 patients (49%). A higher incidence of progression was noted in several other series, but mainly in those with up to only 25 patients [35,44,45,70] (Table 3). McCormack et al observed a contrast enhancement of low-grade gliomas in CT in 22 of 24 patients (92%) suggesting malignant transformation [37].…”

Section: Progression To a High-grade Gliomasupporting

confidence: 70%

Immediate Postoperative Radiotherapy or “Watch and Wait” in the Management of Adult Low-Grade Glioma?

et al. 2004

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The arguments for immediate postoperative irradiation include: low-grade gliomas respond to radiotherapy; the tumors often display an aggressive pathobiological behavior; patients with high risk profile may benefit from immediate radiotherapy in terms of progression-free and overall survival; modern focal radiotherapy is far less toxic than feared; radiotherapy might be more effective at diagnosis than at progression. Chemotherapy might be an alternative in immediate postoperative treatment. Its role, however, is unclear. The forthcoming prospective trial of the EORTC will address this issue in a randomized setting.

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Section: Progression To a High-grade Gliomasupporting

confidence: 70%

Immediate Postoperative Radiotherapy or “Watch and Wait” in the Management of Adult Low-Grade Glioma?

et al. 2004

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“…This has led to the conclusion that well-differentiated tumours have a very slow growth rate [3,4]. From all the studies reported in the last few years it follows that some gliomas appear to be benign from their first occurrence, some start as benign turnouts and become malignant and some are malignant from the outset [5].…”

Section: Introductionmentioning

confidence: 82%

“…There is also no universal agreement as to the timing and efficacy of radiation therapy [3,10,11]. Reports in the literature are contradictory since most of the reported data is difficult to evaluate.…”

Section: Introductionmentioning

confidence: 99%

Combined intra-arterial chemotherapy followed by radiation in astrocytomas

et al. 1992

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Seventy-five patients harboring astrocytomas received 4 cycles of infra-ophthalmic carotid injections of BCNU, combined with vincristine intravenously and procarbazine orally. All of the patients thereafter, received radiation therapy. The five year survival was 73% for all patients. The age of the patients had no significant impact on survival. The treatment results were compared with the results of 57 patients with astrocytomas who were treated with surgery followed by radiation in the same period. These 57 patients had a 5 year survival of 45% with a five year survival in patients < or = 40 years and patients > 40 years of 70% and 22%, respectively (p < 0.05). In multivariate survival analysis of the BCNU group and radiation group together, treatment group and corticosteroid dependency were the only prognostic factors. No leukoencephalopathy was seen during the treatment or in the follow-up of the patients. We conclude that pre-radiation intra-arterial chemotherapy can be given without significant morbidity and produces an improvement in survival in patients older than 40 years.

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“…The traditional treatment strategy for intramedullary astrocytoma is a biopsy to confirm the diagnosis followed by radiation therapy. 4 However, the efficacy of this treatment has been a subject of controversy. Important but presently unsettled issues include the impact of the extent of resection on local control and survival 1,5,6 and the significance of postoperative radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Surgical outcomes of spinal cord astrocytomas

et al. 2006

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Study design: Retrospective case series.Objectives: To analyze prognostic factors for patients with spinal cord astrocytomas. Setting: Department of Orthopaedic Surgery, Keio University, Japan. Methods: Seven patients received total excisions (group T), eight underwent partial excisions (group P), and 15 had excisional biopsies (group B). Impacts of the tumor histological grade, the level of the tumor, the types of surgical interventions, and the use of adjuvant radiotherapies on the survival and functional outcomes of 30 patients (18 in low-grade and 12 high-grade malignancy tumors) were analyzed. Results: The survival rate of the low-grade malignancy group was significantly higher than that of the high-grade group. The survival rate of the patients with thoracic astrocytomas was significantly higher than those with cervical astrocytomas. In both the low-and high-grade groups, the survival rates in groups P/T were significantly higher than those in group B. In the low-grade group, five patients, whose preoperative functional statuses were classified as 'fair' or better, remained 'fair' or better after surgery. In the high-grade group, the postoperative functional statuses were classified as 'no change' or 'aggravated' in all except two patients. No significant difference in the survival rates was detected between patients with and without adjuvant radiotherapy. Conclusions: The tumor grade and the extent of tumor resection were significant prognostic factors for survival rate. In low-grade malignancy group, good motor function was retained when surgeries were performed before substantial neurological deterioration. The efficacy of postoperative radiotherapy has yet to be determined and needs further study.

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Megavoltage irradiation in the treatment of gliomas of the brain and spinal cord

Cited by 96 publications

References 11 publications

Immediate Postoperative Radiotherapy or “Watch and Wait” in the Management of Adult Low-Grade Glioma?

Immediate Postoperative Radiotherapy or “Watch and Wait” in the Management of Adult Low-Grade Glioma?

Combined intra-arterial chemotherapy followed by radiation in astrocytomas

Surgical outcomes of spinal cord astrocytomas

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