Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1 H -pyrazolo[3,4-b]pyridin-6-amines

Govindaraju, Santhosh; Tabassum, Sumaiya; Khan, Riyaz-ur-Rahaman; Päsha, M. A.

doi:10.1016/j.cclet.2016.09.013

Cited by 18 publications

(6 citation statements)

References 54 publications

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“…It is a 6C5CR, since hydrazine is a 2-centered reactant. Pasha and co-workers developed a reaction of substituted phenylacetonitriles, aryl aldehydes, hydrazine, ammonium acetate, and ethyl acetoacetate for the synthesis of 4,7-dihydro-1H-pyrazolo [3,4-b]pyridin-6-amines 13 under the catalysis of meglumine (Scheme 5) [16]. Meglumine has ammonium and alkoxy groups which can activate ethyl acetoacetate and phenylacetonitriles through hydrogen bonding and also donate electrons from the oxygen atom.…”

Section: Type-i 5crs Of a + B + C + D + Ementioning

confidence: 99%

Recent Developments on Five-Component Reactions

Zhi

Zhang

2021

Molecules

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Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.

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Section: Type-i 5crs Of a + B + C + D + Ementioning

confidence: 99%

Recent Developments on Five-Component Reactions

Zhi

Zhang

2021

Molecules

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“…17 Polyvinyl alcohol (PVA) boasts several characteristics ideal for film fabrication in optoelectronics. [18][19][20] It readily forms films due to its excellent film-forming ability. 21 Furthermore, the transparency of PVA allows light to pass through effectively which is a crucial aspect for optoelectronic devices.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the unique properties of PVA can be tailored to specific optoelectronic needs, making it a versatile and eco‐friendly material for the future 17 . Polyvinyl alcohol (PVA) boasts several characteristics ideal for film fabrication in optoelectronics 18–20 . It readily forms films due to its excellent film‐forming ability 21 .…”

Section: Introductionmentioning

confidence: 99%

Synergistic fabrication, characterization, and prospective optoelectronic applications of DES grafted activated charcoal dispersed PVA films

Lokesh Kumar,

Binish,

Rajprasad

et al. 2024

Polymers for Advanced Techs

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This study investigates the synthesis, analysis, and utility of films comprising deep eutectic solvent (DES) grafted activated charcoal (AC) within a polyvinyl alcohol (PVA) matrix for optoelectronic device applications. The fabrication process involves the dispersion of DES functionalization AC into the PVA solution, followed by casting onto substrates with controlled drying. Comprehensive characterization encompassing X‐ray diffraction (XRD), scanning electron microscopy (SEM), UV–vis spectroscopy, Fourier‐transform infrared spectroscopy (FTIR), and impedance spectroscopy which discerns the films microstructure, morphology, conductance, band‐gap, and optical traits. The DES grafted AC infusion with variable concentration has significantly influenced optical absorbance and reduced the band gap indicating efficient charge mobility. Furthermore, the impedance analysis has revealed the electrical conduction of the film to be 1.8 × 10−6 Ω−1 m−1. In summary, the dispersion of DES modified AC in the PVA matrix have converted the insulating PVA to a semiconducting polymeric film with reduced band‐gap and increased absorption, which present a propitious avenue for wide array of optoelectronic devices, such as thin film transistors, photovoltaics, LEDs, photodetectors, and many such applications.

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“…Among these heterocycles, polycyclic heterocycles have received considerable attention because of various applications. Fused heterocyclic compounds such as pyrazolopyridines have biological and pharmacological activities including, antibacterial [4], antimicrobial [5,6], antileishmanial [7,8], antiproliferative agents [9], cytotoxicities, anti-biofilm and antioxidant [10], antimalarial [11], and anticancer [12] have classified as an important and vital structure.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Arlan

Javahershenas

Khalafy

2020

Asian J. Nanosci. Mater.

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In this research study, one-pot, four-component reaction of 3-aryl-3oxopropanenitriles, 1-aryl-3-methyl-1H-pyrazol-5 (4H) one, arylglyoxals and ammonium acetate using green solvent systems and different catalysts under the reflux conditions afforded a series of the corresponding 4-aroyl-3methyl-1,6-diaryl-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile derivatives. The best yields (70-85%) were obtained using the metal oxide silica basedmatal bifunctional LDH (layered double hydroxide) as a magnet nanocatalyst in EtOH/H2O (1:1) under the reflux conditions. This protocol provided mild reaction conditions, good yields, simple workup procedure, easy preparation of nanocatalyst and, products to structurally diverse bicyclic pyrazolo [3,4-b] pyridines, demonstrating biological and pharmacological activities.

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Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1 H -pyrazolo[3,4-b]pyridin-6-amines

Cited by 18 publications

References 54 publications

Recent Developments on Five-Component Reactions

Recent Developments on Five-Component Reactions

Synergistic fabrication, characterization, and prospective optoelectronic applications of DES grafted activated charcoal dispersed PVA films

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