Meibomian Gland Dropout, not Distortion, Can Distinguish Dry Eyes from Normal Eyes in Contact Lens Wearers

Gu, Tianpu; Du, Bei; Bai, Hua; Zhang, Lu; Liu, Guihua; Jin, Nan; Liu, Zhuzhu; Zhang, Bin; Wei, Ruihua

doi:10.1080/02713683.2020.1731829

Cited by 10 publications

(9 citation statements)

References 34 publications

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“…It is generally accepted that the duration of contact lens plays a more critical role on the meibomian gland, rather than lens material (47). If anything, however, OOK lens materials have higher oxygen permeability and induce less hypoxia and inflammation (48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Yuan

et al. 2022

Front. Med.

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PurposePrevious studies suggest that overnight orthokeratology (OOK) may be detrimental to tear function. We aimed to investigate the effect of OOK on lipid layer thickness (LLT), blink pattern, and meibomian gland and elucidate the relationship of these variables.MethodsThirty-seven participants who wore OOK lenses every night for at least 2 years and twenty-four healthy non-contact lens wearers (controls) were enrolled in this retrospective study. LipiView interferometry, blink pattern analysis, the ocular surface status, and morphology and function of the meibomian gland were determined.ResultsThe OOK group and healthy controls had similar LLT, blink patterns, ocular surface status, and the function of the meibomian gland. OOK participants demonstrated higher meiboscore in the lower eyelids (p < 0.05) but not in the upper eyelids. Within the OOK group, LLT was significantly impacted by the partial blink rate (p < 0.05) and the total score of the upper meibomian gland (p = 0.10).ConclusionsWearing OOK for 2 or more years increased lower eyelid meibomian gland dropout but did not have a reduction of LLT.

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Section: Discussionmentioning

confidence: 99%

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Yuan

et al. 2022

Front. Med.

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“…The period of CL wear was 12.3 ± 7.2 years. 18 The authors concluded that CL wearers had significantly higher MGL than age-matched non-CL-wearers.…”

Section: Discussionmentioning

confidence: 96%

Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage

Fattoh¹,

Mounir²,

Anbar³

et al. 2022

OPTH

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Purpose The study aimed to determine changes detected by noncontact meibography and noninvasive break-up time test (NIBUT) in individuals with regular use of soft contact lenses and compare these findings with irregular soft contact lenses wearers who not compliant with them and non-wearers control group. Patients and Methods A prospective nonrandomized case-control study in which individuals were recruited and distributed into three groups: Group A (regular contact lens wearers), group B (irregular contact lens wearers), and group C (non-wearers). Ocular Surface Disease Index (OSDI) was obtained. Noncontact meibography and noninvasive tear break-up time were measured without lenses on using Sirius ® Scheimpflug Camera. Results One hundred sixty-six eyes of 83 individuals were included; 36 eyes in group A, 50 eyes in group B, and 80 eyes in group C. The mean total meiboscore was 1.99, 1.61, and 1.28, respectively. The mean meibograde was 3.03, 2.86, and 1.99, respectively. Noninvasive break-up time (NIF-BUT) was 8.42, 11.76, and 13.57 seconds, respectively. Conclusion There is a difference in OSDI score, meibomian score, and break-up time between different study groups. The study results show that there are trends in lens wearers and non-lens wearers. This is useful for the field to understand the differences between lens wearers and non-lens wearers.

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“…MG tortuosity has been associated with contact-lens wear and more commonly observed in Caucasians. 22,23 Gu et al 14 found that MG distortion and dropout was higher in DED patients compared to normal patients. However, they found that only dropout could distinguish DED patients from healthy patients in both Contact-lens wearing patients and non-contact lens wearing patients, while MG distortion could only distinguish this in non-contact lens wearers.…”

Section: Discussionmentioning

confidence: 98%

“…11,12 Most of the studies about morphological changes in MG focus on the presence and severity of dropout of MG, as a marker for severity in the assessment of MGD. 6,8,[13][14][15][16] Recently, Daniel et al 7 proposed a classi cation system that not only evaluates the percentage of MG dropout but also analyzes different morphological alterations that could be correlated with other clinical parameters We found that the upper lid had higher frequency of morphological alterations than the lower lid, this result was also found by Daniel´s study, 7 but the frequency of subjects with LL alterations was bigger in our study, this could be related to the population studied since we focused in evaporative dry eye and healthy subjects, while in the Daniel´s population, patients with all types of dry eye and almost 40% patients with autoimmune diseases were included. Patients with autoimmune disease demonstrated a lower frequency of alterations, mainly distorted glands and ghost glands in the UL and shortened glands in the LL, also, the difference in the frequency of alterations could be related to the largest sample size of the Daniel´s study.…”

Section: Discussionmentioning

confidence: 99%

Comparative of Meibomian Gland Morphology in Patients With Evaporative Dry Eye Versus Non-Dry Eye

Crespo-Treviño

Salinas-Sánchez

Amparo

et al. 2021

Preprint

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Many recent studies have demonstrated that morphological changes are one of the key signs of Meibomian gland disease (MGD) . These changes can be seen even before symptom onset, potentially underestimating the prevalence of MGD; however, Until now, there is no conclusive information about the impact of MG morphology in tear film physiology and disease. This study aimed to investigate the prevalence of anatomical and morphological MG alterations between patients with evapo-rative DED and healthy controls. Retrospective chart review of Seventy-five patients with evaporative dry eye and healthy individuals who had dry eye assesments included Ocular Surface Disease Index questionnaire, Meibum quality, meibum expressibility, lid margin abnormality, ocular staining, non-invasive tear film break-up time, and Meibography. We did not find significant differences in MG alterations in the upper lid between healthy and dry-eye subjects. Patients with evaporative dry eye presented MG alterations in the lower lid more frequently than healthy subjects (54.8 vs 30.3%; p=0.03). The presence of shortened glands was the only MG alteration that was more prevalent in the lower lid in dry-eye patients than in healthy subjects (p <0.05). Subjects with evaporative dry eye presented more alterations in the lower lid than healthy subjects.

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Meibomian Gland Dropout, not Distortion, Can Distinguish Dry Eyes from Normal Eyes in Contact Lens Wearers

Cited by 10 publications

References 34 publications

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage

Comparative of Meibomian Gland Morphology in Patients With Evaporative Dry Eye Versus Non-Dry Eye

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