Meigs’ Syndrome with Elevated Serum CA125: Case Report and Review of the Literature

Abstract

An elevated serum CA125 level in association with a pelvic mass, pleural effusion, and massive ascites usually signifies a dismal prognosis in a postmenopausal woman. However, surgery and histopathological examination are required for the correct diagnosis and treatment, since an elevated CA125 level can be falsely positive for ovarian malignancy. We present a case of Meigs’ syndrome due to right ovarian fibroma with elevated CA125 level in a postmenopausal woman.

A Case of Meigs’ Syndrome: The 18F-FDG PET/CT Findings

“…In a study with 115 patients with histologically proven nonmalignant pelvic tumor, a significantly elevated CA-125 level was found in 14 patients and the highest values were detected in the patients with ascites [10]. There are some case reports of elevated CA-125 levels in patients with Meigs' syndrome, and in some of them, the levels of CA-125 were over 1,000 U/mL [2,11]. Therefore, pathologic evaluation of ovarian tumor is needed to make the correct diagnosis since the tumor markers and the other indicators of malignancy may be misleading [2].…”

Ovarian Adenocarcinoma with Serous Effusions Appeared after a Mammary Adenocarcinoma: A Case Report

“…The marked increase of CA125 associated with Demons Meigs Syndrome is a very rare condition, with few cases reported in the literature. In these situations, the precise diagnosis is made by a histopathological examination [6].…”

Meig’s Syndrome with Elevated CA 125: Case Report with a Journey through Literature

“…The occurrence of pleural effusion associated with ascites and an ovarian fibroma or fibro thecoma was first described as a clinical syndrome by Meigs and Cass in 1937 [1][2][3]. Elevated serum carbohydrate antigen 125 (CA 125) leves in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor [1][2][3][4].…”

“…Elevated serum carbohydrate antigen 125 (CA 125) leves in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor [1][2][3][4]. A minority of these patients has a benign condition known as Meigs' syndrome; therefore it is mandatory surgery and histological confirmation of the preoperative diagnosis [2].…”

“…Elevated serum carbohydrate antigen 125 (CA 125) leves in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor [1][2][3][4]. A minority of these patients has a benign condition known as Meigs' syndrome; therefore it is mandatory surgery and histological confirmation of the preoperative diagnosis [2]. Clinicians should be aware of this clinical entity because of its benignity and differential diagnosis with malignant ovarian tumors that can be similar at presentation but have a different treatment and prognosis [5][6][7][8].…”