Human influence on Antarctic marine ecosystems is a growing concern, despite limited information being available. This study investigated the coastal meiofauna and environmental parameters of 10 locations, 4 of which served as reference points (OB1, OB2, OB3, and McGrady) and 6 which were impacted by different levels of human activity in the past and present (Wharf, Wilkes, BBIN, BBMID, BBOUT, and Shannon) in East Antarctica. Environmental variables such as metals, total petroleum hydrocarbons (TPHs), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), grain size, organic matter content, and nutrients were measured for analysis. Locations close to human activities showed higher concentrations of pollutants (metals, TPHs, PBDEs, PCBs) and greater variations in meiofauna diversity compared to the reference sites (OB1, OB2, OB3, and McGrady). In the area impacted by the Casey Station waste dump (Brown Bay), the meiofauna community at the location furthest from the pollution (BBOUT) source exhibited greater diversity compared to the closest location (BBIN). In addition to metals and TPHs, particle size was also correlated with community patterns, with finer sediments associated with more impacted sites, facilitating the accumulation of toxic compounds. These results contribute to the understanding of the role and impact of pollutants on meiofauna biodiversity in Antarctic coastal ecosystems.