1994
DOI: 10.1242/jcs.107.11.3005
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Meiosis-specific cell cycle regulation in maturing Xenopus oocytes

Abstract: Meiotic cell cycles differ from mitotic cell cycles in that the former lack S-phase in the interphase between meiosis I and meiosis II. To obtain clues for mechanisms involved in the cell cycle regulation unique to meiosis, we have examined changes in chromosomal morphology and H1 kinase activity during a meiotic period from metaphase I (MI) to metaphase II (MII) in Xenopus oocytes. Using populations of oocytes that underwent germinal vesicle breakdown (GVBD) within a 10 minute interval, we found that the kina… Show more

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Cited by 55 publications
(12 citation statements)
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“…The mechanisms responsible for preventing the complete degradation of cyclin B at the end of MI are unknown. We note that in MI the amount of cyclin B decreases more slowly than it does in other M phases (Ohsumi et al, 1994), suggesting that some speci®c regulation of cyclin B degradation may operate in MI. It is noteworthy that the protein kinase c-Mos, which plays an essential role in the inhibition of cyclin B degradation at metaphase II arrest (Sagata, 1996), is also required for the suppression of S phase during the MI±MII transition period (Furuno et al, 1994).…”
Section: Discussionmentioning
confidence: 65%
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“…The mechanisms responsible for preventing the complete degradation of cyclin B at the end of MI are unknown. We note that in MI the amount of cyclin B decreases more slowly than it does in other M phases (Ohsumi et al, 1994), suggesting that some speci®c regulation of cyclin B degradation may operate in MI. It is noteworthy that the protein kinase c-Mos, which plays an essential role in the inhibition of cyclin B degradation at metaphase II arrest (Sagata, 1996), is also required for the suppression of S phase during the MI±MII transition period (Furuno et al, 1994).…”
Section: Discussionmentioning
confidence: 65%
“…Cdc2 was tyrosine phosphorylated during the slow‐activation period (Figure 1G). Thus, oocyte extracts reproduce in vitro the major characteristics of the meiosis‐specific regulation of cyclin B–Cdc2 kinase, including incomplete degradation of cyclin B at the end of MI and the absence of Cdc2 inhibitory phosphorylation during the MI–MII transition period (Ohsumi et al ., 1994), along with the M–M transition unique to meiotic cycles. We refer to these extracts as ‘meiotic extracts’.…”
Section: Resultsmentioning
confidence: 99%
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