2023
DOI: 10.1101/2023.08.04.552061
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

MEK inhibition enhances the antitumor effect of radiation therapy inNF1-deficient glioblastoma

Maria Ioannou,
Kriti Lalwani,
Abiola A. Ayanlaja
et al.

Abstract: Individuals with neurofibromatosis type 1 (NF-1), an autosomal dominant neurogenetic and tumor predisposition syndrome, are susceptible to developing low-grade glioma (LGG) and, less commonly, high-grade glioma (HGG). These gliomas exhibit loss of the neurofibromin gene (NF1), and 10-15% of sporadic HGG have somatic NF1 alterations. Loss of NF1 leads to hyperactive RAS signaling, creating opportunity given the established efficacy of MEK inhibitors (MEKi) in plexiform neurofibromas and some individuals with LG… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 37 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?