Melamine-induced infant urinary calculi: a report on 24 cases and a 1-year follow-up

Zhang, Xiangbo; Bai, Jingping; Ma, Pengcheng; Ma, Junsheng; Wan, Jianghou; Jiang, Bin

doi:10.1007/s00240-010-0279-0

Cited by 13 publications

(5 citation statements)

References 17 publications

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“…15 Six children in the current study did not show abnormalities in renal sonography. Sudden and complete anuria in these children with no contributing history or specific laboratory findings for other causes led us to confirm PARF in these children.…”

Section: Discussionmentioning

confidence: 46%

Ceftriaxone and Acute Renal Failure in Children

Zhou

Yuan

et al. 2014

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Ceftriaxone at therapeutic doses can lead to renal stone formation. WHAT THIS STUDY ADDS:Renal stone formation with ceftriaxone therapy can result in postrenal acute renal failure in children. The condition can be treated effectively by timely pharmacotherapy or retrograde ureteral catheterization with good prognosis. abstract OBJECTIVE: Our aim was to evaluate the clinical profile, treatment, and outcome of ceftriaxone-associated postrenal acute renal failure (PARF) in children. METHODS:We retrospectively studied 31 consecutive cases from 2003 to 2012 for PARF after ceftriaxone treatment. There was no past history of urolithiasis or nephropathy in these children. RESULTS:The average time of ceftriaxone administration before PARF was 5.2 days. The major symptoms apart from anuria included flank pain (.3 years old, 25/25), excessive crying (,3 years, 6/6), and vomiting (19/33). Ultrasound showed mild hydronephrosis (25/31) and ureteric calculi (11/31). Nine children recovered after 1 to 4 days of pharmacotherapy. Twenty-one children who were resistant to pharmacotherapy underwent retrograde ureteral catheterization. After catheterization of their ureters, normal urine flow was observed, and the symptoms subsided immediately. Catheter insertion failed in 1 child who subsequently underwent 3 sessions of hemodialysis before normal urination was restored. Ceftriaxone was verified to be the main component of the calculi in 4 children by tandem mass spectrometric analysis. The recovery was complete in all cases.CONCLUSIONS: Ceftriaxone therapy in children may cause PARF. Early diagnosis and prompt pharmacological therapy are important in relieving the condition. Retrograde ureteral catheterization is an effective treatment of those who fail to respond to pharmacotherapy. Pediatrics 2014;133:e917-e922 Ceftriaxone at therapeutic doses can lead to crystallization in the urine and these crystals adhere to the surface of renal tubular cells. 5 Severe nephrolithiasis can cause postrenal acute renal failure (PARF). To date there are only a few studies reporting on PARF associated with ceftriaxone. [9][10][11] Our aim was to study the clinical features, treatment, and outcome of ceftriaxone-associated PARF in children. METHODSBetween January 1, 2003 and June 30, 2012, of the 127 PARF children admitted to the Pediatric Surgery Department of Tongji Hospital, there were 31 children who had a history of ceftriaxone administration a few days before PARF. These children were identified as subjects for the study. The history of ceftriaxone treatment was verified from patient records in 9 children and reported by parents in the remaining 22 children.The diagnosis of PARF was based on sudden onset of anuria, flank pain, and renal percussion pain associated with elevated serum creatinine and/or serum urea nitrogen in a child who had no past history of urolithiasis. The renal ultrasonography findings included normal-sized kidneys, the presence or absence of hydronephrosis, or ureteric calculi with no renal v...

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Section: Discussionmentioning

confidence: 46%

Ceftriaxone and Acute Renal Failure in Children

Zhou

Yuan

et al. 2014

Pediatrics

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“…Furthermore, previous studies demonstrated that both catechin and citrate exhibit similar inhibitory mechanisms against MEL–CYA stone formation [ 1 , 46 ]: (1) in vitro experiments revealed that the addition of sodium citrate and catechin effectively suppressed MEL–CYA crystal formation when the pH was below 7; (2) animal experiments indicated that both catechin and sodium citrate significantly inhibited melamine–cyanuric acid-induced OPN expression, which is closely associated with crystal formation and retention [ 47 ]. Considering the widespread clinical use of citrate for kidney stone treatment, due to its ability to alkalinize urine and reduce urine saturation [ 48 ], it is worth exploring whether catechin can also alleviate kidney stones by modulating urinary alkalinity and mitigating the physical as well as chemical risk factors involved in stone formation.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Effect of Catechin on Nephrolithiasis Induced by Co-Exposure to Melamine and Cyanuric Acid in Sprague–Dawley Rats

Wang,

Liu,

Liu

et al. 2023

Toxics

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This study aimed to assess the therapeutic efficacy of catechin against experimentally induced kidney stones resulting from co-exposure to melamine (MEL) and cyanuric acid (CYA) in male Sprague–Dawley rats. To induce nephrolithiasis, a combination of MEL and CYA (1:1 ratio, each at a dose of 31.5 mg/kg bw/day) was administered to the rats for 28 consecutive days. After nephrolithiasis was successfully induced, the rats were randomly divided into two groups: a treatment group and a sham group. The treatment group was given a daily oral dose of 50 mg/kg of catechin for 28 days, while the sham group received no intervention. Urine and blood samples were collected throughout the treatment period, and kidney samples were taken on day 28. Our findings demonstrated that treatment with catechin significantly reduced crystal deposition and pathological damage in the rats from nephrolithiasis. Additionally, renal injury markers were significantly decreased in the treatment group compared to the sham group. These findings suggest that catechin has potential therapeutic benefits in treating nephrolithiasis induced by co-exposure to MEL and CYA.

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“…Sanlu brand milk powder contained excessive levels of melamine, an ingredient introduced by dairy farmers. This tainted milk caused infant urinary calculi, causing health problems in over 6,000 infants (Zhang et al, 2010). Eventually, this event led to Sanlu Group's bankruptcy.…”

Section: Challenges Related To Gscm and Potential Responsesmentioning

confidence: 99%

Choosing the right approach to green your supply chains

Zhu

Sarkis

Lai

2019

MSCRA

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Purpose Due to the different institutional pressure such as those from market, regulations and competitors, companies have implemented green supply chain management (GSCM). Unfortunately, tens of GSCM practices exist. Whether all companies should implement GSCM and how to achieve both environmental and economic performance are still not clear for many companies. The purpose of this paper is to develop models that can be helpful for companies to identify right GSCM practices and implement GSCM effectively and efficiently. Design/methodology/approach Based on about 18 years of study on GSCM with four surveys in China in 2001, 2005, 2012 and 2016, as well as numerous site visits and interviews mainly in China but also in Japan, Germany and Canada, this paper explores institutional drivers as well as opportunities and challenges using theoretical analysis and case studies. GSCM is defined considering a product life cycle. A key three-step GSCM approach is theoretically developed considering opportunities and challenges through life cycle analysis (LCA) of a product and position of a company. Findings All companies should implement GSCM practices to avoid risks. To effectively implement GSCM practices, a company should understand the life cycle of its product and its position in the supply chain. A key three-step LCA-based approach can help companies to identify the critical GSCM practices. Originality/value A key three-step LCA-based approach for GSCM implementation is originally developed based on theoretical analysis and eight years of study.

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Melamine-induced infant urinary calculi: a report on 24 cases and a 1-year follow-up

Cited by 13 publications

References 17 publications

Ceftriaxone and Acute Renal Failure in Children

Ceftriaxone and Acute Renal Failure in Children

The Therapeutic Effect of Catechin on Nephrolithiasis Induced by Co-Exposure to Melamine and Cyanuric Acid in Sprague–Dawley Rats

Choosing the right approach to green your supply chains

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