Melamine residues in eggs of laying hens exposed to melamine-contaminated feed

Yang, Tae Sung; Huang-Fu, Wei-Guo; Wu, Yinan

doi:10.3382/ps.2010-00775

Cited by 19 publications

(17 citation statements)

References 8 publications

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“…The existence of an excretion pattern from feed to eggs was also reported (Bai et al, 2010;Chen et al, 2010;Dong et al, 2010;Valat et al, 2011;Yang et al, 2011). Our results confirmed that melamine could be found in eggs from hens ingesting melamine-contaminated diets, also at a low-level of melamine concentration (i.e.…”

Section: Resultssupporting

confidence: 87%

“…However, referring to tabular data reported by Chen et al (2010), a similar melamine egg excretion pattern could be observed. A different trend in melamine excretion pattern was reported by Yang et al (2011). The authors observed that the melamine in egg tended to increase from day 1 to days 18 and 19 for groups fed 200 and 1000 mg of melamine/kg of diet, respectively.…”

Section: Resultsmentioning

confidence: 68%

“…The melamine egg concentrations (data corrected for the recoveries percentages) increased rapidly, with melamine being detected in eggs produced on day 1 in all groups. Other authors suggested that melamine was rapidly distributed to egg (Chen et al, 2010;Dong et al, 2010;Valat et al, 2011;Yang et al, 2011). On the contrary, Bai et al (2010) did not detect melamine on the first day of melamine ingestion, reporting that melamine egg concentration peaked on day 2 when hens were fed diet from 8.6 to 140.9 mg of melamine/kg of BW.…”

Section: Resultsmentioning

confidence: 98%

“…A wide range of melamine diet concentrations, ranging from 0 to 1000 mg/kg were tested by Lü et al (2009) to evaluate the tissue residual melamine of broilers. Recently, Yang et al (2011) used similar melamine concentrations by feeding laying hens with 200 or 1000 mg of melamine/kg of diet, whereas Valat et al (2011) exposed animals to two melamine-contaminated diets with 50 and 500 mg of melamine/kg of diet, respectively. In our condition, no illness and death cases were recorded during the experimental period.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, a carryover of melamine from feed to egg and body tissues of laying hens has been reported by different authors (Bai et al, 2010;Chen et al, 2010;Dong et al, 2010;Valat et al, 2011;Yang et al, 2011). Recently, a pathway of melamine accumulation in various tissues (i.e.…”

Section: Introductionmentioning

confidence: 98%

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Melamine in eggs, plasma and tissues of hens fed contaminated diets

Gallo

Bertuzzi

Battaglia

et al. 2012

Animal

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A study was conducted to evaluate the excretion pattern of melamine from feed into eggs, plasma, kidney, liver and muscle of laying hens. In particular, 90 laying hens were randomly allocated to three dietary treatments and fed diets contaminated with melamine at a level of 2.5, 25 and 250 mg of melamine/kg of diet for T1, T2 and T3 groups, respectively. The diets were offered in six replicate boxes (five hens each) for 13 days. Eggs were collected from each group for melamine quantification on days 0, 1, 3, 6, 9 and 13. At the end of the experimental period, one hen per box was randomly selected and slaughtered to collect plasma, liver, kidney and muscle samples. During the experiment, feeding diets with increasing levels of melamine had no effect (P . 0.05) on weight gain, feed intake, egg production, egg weight and mortality of laying hens. The melamine in eggs increased from day 1 after melamine ingestion and reached a plateau between days 6 and 13 of melamine ingestion. At steady-state condition, the melamine egg concentrations increased (P , 0.01) with treatments, being 0.026, 0.352 and 4.631 mg/kg for T1, T2 and T3, respectively. Similarly, the carryover of melamine from feed to egg increased (P , 0.05) with the levels of melamine in the diets, varying from 0.50 to 0.70 and 0.84 for T1, T2 and T3, respectively. The melamine was detected in plasma of all tested groups, increasing (P , 0.01) with levels of melamine in the diets (0.030, 0.266 and 4.102 mg/l in T1, T2 and T3, respectively). Melamine was not detected in kidney, liver and muscle of hens fed T1. Except for kidney sampled in the T3, no melamine concentration higher than 2.5 mg/kg, representing the maximum allowable limit set by the US Food and Drug Administration and European Union for food and feeds, was measured. The melamine resulted higher in plasma and kidneys than in the liver and muscle both in T2 and T3. The results confirmed the presence of an excretion pattern of melamine from feed to eggs and tissues in laying hens.

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 68%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Melamine in eggs, plasma and tissues of hens fed contaminated diets

Gallo

Bertuzzi

Battaglia

et al. 2012

Animal

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Benchmark dose analysis framework for developing wildlife toxicity reference values

Mayfield

Skall

2018

Enviro Toxic and Chemistry

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The effects characterization phase of ecological risk assessments (ERAs) often includes the selection or development of toxicity reference values (TRVs) for chemicals under investigation. In wildlife risk assessments, TRVs are thresholds represented by a dose or concentration associated with a specified adverse response. Traditionally, a TRV may be derived from an estimate of the no-observed-adverse effect level or lowest-observed-adverse-effect level, identified from a controlled toxicity study. Because of the limitations of this approach, risk assessors are increasingly developing TRVs using alternative methods. Benchmark dose (BMD) analysis is widely recognized as one approach for developing TRVs. A BMD is derived using the full dose-response relationship from all experimental doses and may represent a user-specified response level (e.g., 5, 10, 20, or 50%). Although many regulatory programs consider the use of BMD-derived wildlife TRVs, there is limited guidance available for implementing the BMD approach, particularly for ERA. The present study provides a framework for ecological risk assessors to identify appropriate data, examine dose-response relationships, estimate BMDs, and document the results for use in risk analysis. This framework demonstrates the process of developing a TRV using BMD analysis and identifies applications for which this approach may enhance ERAs (e.g., site assessment, chemical or pesticide registration programs). Environ Toxicol Chem 2018;37:1496-1508. © 2018 SETAC.

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