Melamine-supported nickel oxide nanoparticles as a good alternative to conventional copper catalysts for the regioselective synthesis of triazole derivatives in water

Nanocatalysts: applications for the synthesis of N-containing five-membered heterocycles

“…Furthermore, the catalyst can be easily isolated and reused at least 6 times without any noteworthy reduction in its catalytic efficiency. 68 …”

“…Furthermore, the catalyst can be easily isolated and reused at least 6 times without any noteworthy reduction in its catalytic efficiency. 68 Raghavendra et al have disclosed preparation of N a -protected amino keto-1,2,3-triazoles through the three-component reaction between amino acyl chloride derivatives of protected amino acids/dipeptide acids, phenylacetylene and sodium azide catalysed by the nano-CuO catalyst (Scheme 40). Many of the procedures for the formation of 1,2,3-triazoles reported in the literature suffer from the problems like use of huge surplus costly chemicals, inconsiderate situation, prolonged process, low yields and several in situ generated intermediates which need unique concern for the nal products.…”

Nanostructured Ni(OH)2–ZnO mixed crystals as recyclable catalysts for the synthesis of N-unsubstituted 1,2,3-triazoles

“…In the recent years, nickel based catalysts have been in the spotlight for the development of N-substituted 1,2,3-triazoles. [30][31][32][33][34] Getting fortified from these works, we thought of incorporating nickel to our catalytic system with a view that it may adhere some synergistic effect on ZnO nanoparticles that will enhance the formation of N-unsubstituted triazoles with a gratifying yield. Hence, by using the co-precipitation method, we prepared Ni(OH) 2 -ZnO nanostructured mixed crystals which when added to the reaction mixture produced the desired triazole with excellent yield(~96%)(Figure S1, SI).…”