Melancholia Associated With Severe Cognitive Disorders as the Expression of Late-Onset Postpartum Anti–<i>N</i>-Methyl-<scp>d</scp>-Aspartic Acid Receptor Limbic Encephalitis

Lalanne, Laurence; Jantzi, Camille; Gorse, Audrey; Zimmermann, Marie-Agathe; Danion, Jean-Marie; Foucher, Jack

doi:10.1176/appi.neuropsych.14040079

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Among them, some cases of catatonia associated with autoimmune diseases have been described in systemic lupus erythematosus, anti-NMDAR (N-methyl-d-aspartate receptor) encephalitis [ 5 – 8 ], paraneoplasic syndrome [ 7 , 9 , 10 ], PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder) [ 11 ] and in other rare syndromes like Wilson disease [ 12 ]. First line recommended treatementr in catatonia are benzodiazepine and ECT [ 13 ] but, in case of SLE and anti-NMDAR encephalitis in adults, etiological treatment, respectively plasma exchange and immunoglobulin perfusion associated with corticosteroid, is an efficient option avoiding using ECT and psychotropic drugs [ 14 , 15 ]. Here we present a case highlighting that, as psychiatric symptoms can be prominent in encephalopathy, the presence of catatonia associated with psychotic features can be a misleading presentation for an underlying organic aetiology.…”

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confidence: 99%

Attempted infanticide and suicide inaugurating catatonia associated with Hashimoto’s encephalopathy: a case report

et al. 2016

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BackgroundCatatonia is a neuropsychiatric syndrome with motor and behavioural symptoms. Though usually occuring in patients with schizophrenia and mood disorders, this syndrome may also be associated with neurological diseases or general medical conditions. Few cases of catatonia associated with autoimmune disorders have been described.Case presentationHere, we report the case of a 27-year-old woman diagnosed with Hashimoto’s encephalitis (HE) who attempted suicide and infanticide by defenestration. As she presented risk factors for postpartum psychosis, she was treated principally with antipsychotics. Despite adequate treatment for psychosis, symptoms worsened and she developed catatonia. Complementary investigations showed elevated titres of anti-thyroglobulin and anti-thyroperoxidase antibodies (200 and 10 times, respectively, as compared to normal levels) and electroencephalography were suggestive of encephalopathy. In the presence of an otherwise unexplained neuropsychiatric condition, HE was suspected and oral prednisolone was introduced. Psychiatric symptoms improved dramatically within 72 h and the patient was still free of any symptom 3 years later.ConclusionCatatonia of organic aetiology should always be considered before a psychiatric aetiology especially in case of clinical worsening in spite of adequate psychotropic treatment. To our knowledge, this is the first description of catatonia associated with HE.

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Section: Introductionmentioning

confidence: 99%

Attempted infanticide and suicide inaugurating catatonia associated with Hashimoto’s encephalopathy: a case report

et al. 2016

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“…Additionally, Lalanne et al. ( 18 ) discuss melancholia associated with severe cognitive disorders as an expression of late-onset postpartum anti–N-methyl-D-aspartic acid receptor limbic encephalitis, further highlighting the intricate link between psychiatric symptoms and organic etiologies.…”

Section: Discussionmentioning

confidence: 99%

Case report: Assessing criminal responsibility and recidivism risk in the behavioral variant of frontotemporal dementia

Karcher,

Hamza,

Jantzi

2024

Front. Psychiatry

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Frontotemporal dementia (FTD) affects the frontal and temporal lobes of the brain, leading to personality changes, language impairments, and behavioral disturbances, including impulsivity and disinhibition. Assessing responsibility and recidivism risk in forensic evaluations is challenging due to the evolving nature of FTD. Despite limited literature, we present a case of a 45-year-old man with no prior legal or medical history, who committed criminal acts due to behavioral changes linked to the behavioral variant of frontotemporal dementia (bvFTD). Initial assessment found him irresponsible, with a non-evaluable risk of recidivism. Subsequent evaluation showed a low recidivism risk based on clinical evolution. We discuss these findings considering existing literature and Swiss jurisprudence.

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Catatonia in N-methyl-d-aspartate receptor antibody encephalitis: Phenomenological characteristics from a systematic review of case reports

Serra-Mestres

Villagrasa²,

Thacker³

et al. 2020

General Hospital Psychiatry

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Melancholia Associated With Severe Cognitive Disorders as the Expression of Late-Onset Postpartum Anti–N-Methyl-d-Aspartic Acid Receptor Limbic Encephalitis

Cited by 4 publications

References 7 publications

Attempted infanticide and suicide inaugurating catatonia associated with Hashimoto’s encephalopathy: a case report

Attempted infanticide and suicide inaugurating catatonia associated with Hashimoto’s encephalopathy: a case report

Case report: Assessing criminal responsibility and recidivism risk in the behavioral variant of frontotemporal dementia

Catatonia in N-methyl-d-aspartate receptor antibody encephalitis: Phenomenological characteristics from a systematic review of case reports

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