Melanin-concentrating hormone is expressed in the laterodorsal tegmental nucleus only in female rats

Rondini, Tatiane Araujo; Rodrigues, Bruno de Crudis; Oliveira, Anne Pierre de; Bittencourt, Jackson C.; Elias, Carol F.

doi:10.1016/j.brainresbull.2007.04.006

Cited by 34 publications

(23 citation statements)

References 58 publications

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“…Several studies have suggested that the MCH system exhibits anatomic and functional sexual dimorphism (Mogi et al, 2005;Rondini et al, 2007;Santollo and Eckel, 2008). For example, glucose-induced inactivation of MCH neurons after fasting come up more rapidly in female than in male rats (Mogi et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…We previously described that MCH neurons in the brainstem and in the incerto-hypothalamic area coexpress the GABA synthesizing enzyme glutamic acid decarboxylase (GAD-67) mRNA (Rondini et al, 2007;Sita et al, 2007). Thus, we investigated whether neurons expressing ppMCH mRNA during lactation also coexpress GAD-67 mRNA.…”

Section: Chemical Identity and Innervation Of Mpo Neurons Expressing Mchmentioning

confidence: 97%

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Chemical identity and connections of medial preoptic area neurons expressing melanin-concentrating hormone during lactation

Rondini¹,

Donato²,

Rodrigues³

et al. 2010

Journal of Chemical Neuroanatomy

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Section: Discussionmentioning

confidence: 99%

Section: Chemical Identity and Innervation Of Mpo Neurons Expressing Mchmentioning

confidence: 97%

Chemical identity and connections of medial preoptic area neurons expressing melanin-concentrating hormone during lactation

Rondini¹,

Donato²,

Rodrigues³

et al. 2010

Journal of Chemical Neuroanatomy

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“…In addition to their close localization to the Hcrt neurons within the LH [32], MCH-producing neurons (~12000 in the rat brain [30]) are also found in the ZI (Fig. 1b) [9,33]. Low levels of MCH mRNA have been detected in the pontine reticular formation and the protein was localized immunohistochemically in the caudal laterodorsal tegmental nucleus of rat brain [9,33,34].…”

Section: Hcrt and Mch Systemsmentioning

confidence: 90%

“…1b) [9,33]. Low levels of MCH mRNA have been detected in the pontine reticular formation and the protein was localized immunohistochemically in the caudal laterodorsal tegmental nucleus of rat brain [9,33,34]. In the mammalian brain, both neuronal populations send parallel overlapping projections to several brain areas including the cortex, hippocampus, amygdala, nucleus accumbens, the hypothalamus itself, thalamus, ventral tegmental area (VTA), locus coeruleus (LC) and the raphe.…”

Section: Hcrt and Mch Systemsmentioning

confidence: 96%

“…Hcrt and MCH neurons are thus highly interconnected with a network of glutamatergic, GABAergic, dopaminergic and cholinergic neurons. Hcrt neurons coexpress glutamate [71] and part of the CART-expressing MCH neurons also express the glutamate decarboxylase enzyme suggesting that a subpopulation of MCH neurons are GABAergic [33,45]. Recently, substance P has been colocalized with a few MCH neurons [72].…”

Section: Input and Ouputmentioning

confidence: 96%

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Physiological arousal: a role for hypothalamic systems

Adamantidis

Lecea

2008

Cell. Mol. Life Sci.

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The lateral hypothalamus (LH) has long been known as a homeostasis center of the brain that modulates feeding behavior, arousal and reward. The hypocretins (Hcrts, also called orexins) and melaninconcentrating hormone (MCH) are neuropeptides produced in two intermingled populations of a few thousand neurons in the LH. The Hcrts have a prominent role in regulating the stability of arousal, since Hcrt system deficiency leads to narcolepsy.MCH is an important modulator of energy balance, as MCH system deficiency in mice leads to leanness and increased metabolism. Recently, MCH has been proposed to modulate rapid eye movement sleep in rodents. In this review, we propose a working model of the cross-talk between Hcrt and MCH circuits that may provide an arousal balance system to regulate complex goal-oriented behaviors.

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Melanin‐concentrating hormone peptidergic system: Comparative morphology between muroid species

Diniz

Battagello

Cherubini

et al. 2019

J of Comparative Neurology

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Melanin-concentrating hormone (MCH) is a conserved neuropeptide, predominantly located in the diencephalon of vertebrates, and associated with a wide range of functions. While functional studies have focused on the use of the traditional mouse laboratory model, critical gaps exist in our understanding of the morphology of the MCH system in this species. Even less is known about the nontraditional animal model Neotomodon alstoni (Mexican volcano mouse). A comparative morphological study among these rodents may, therefore, contribute to a better understanding of the evolution of the MCH peptidergic system. To this end, we employed diverse immunohistochemical protocols to identify key aspects of the MCH system, including its spatial relationship to another neurochemical population of the tuberal hypothalamus, the orexins. Three-dimensional (3D) reconstructions were also employed to convey a better sense of spatial distribution to these neurons. Our results show that the distribution of MCH neurons in all rodents studied follows a basic plan, but individual characteristics are found for each species, such as the preeminence of a periventricular group only in the rat, the lack of posterior groups in the mouse, and the extensive presence of MCH neurons in the anterior hypothalamic area of Neotomodon. Taken together, these data suggest a strong anatomical substrate for previously described functions of the MCH system, and that particular neurochemical

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Melanin-concentrating hormone is expressed in the laterodorsal tegmental nucleus only in female rats

Cited by 34 publications

References 58 publications

Chemical identity and connections of medial preoptic area neurons expressing melanin-concentrating hormone during lactation

Chemical identity and connections of medial preoptic area neurons expressing melanin-concentrating hormone during lactation

Physiological arousal: a role for hypothalamic systems

Melanin‐concentrating hormone peptidergic system: Comparative morphology between muroid species

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