Melanin-concentrating hormone (MCH) modulates the activity of dorsal raphe neurons

Devera, Andrea; Pascovich, Claudia; Lagos, Patricia; Falconi, Atilio; Sampogna, Sharon; Chase, Michael H.; Torterolo, Pablo

doi:10.1016/j.brainres.2014.12.032

Cited by 38 publications

(26 citation statements)

References 58 publications

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“…), and that MCH inhibits the firing of DRN neurons (Devera et al . ). If MCH neurons do not indeed package and release synaptic GABA, they may alternatively inhibit REM‐Off neurons directly through MCH release or indirectly through glutamate‐mediated feedforward inhibition (Chee et al .…”

Section: Rem Circuitry: the Pontine Rem Atonia Generatormentioning

confidence: 97%

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The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep

Arrigoni

Chen

Fuller

2016

The Journal of Physiology

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is thought to originate from glutamatergic neurons of the sublaterodorsal nucleus (SLD), which in turn activate glycinergic pre-motor neurons in the spinal cord and/or ventromedial medulla to inhibit motor neurons. Despite work over the past two decades on many neurotransmitter systems that regulate the SLD, gaps remain in our knowledge of the synaptic basis by which SLD REM neurons are regulated and in turn produce REM sleep atonia. Elucidating the anatomical, cellular and synaptic basis of REM sleep atonia control is a critical step for treating many sleep-related disorders including obstructive sleep apnoea (apnea), REM sleep behaviour disorder (RBD) and narcolepsy with cataplexy. Abbreviations BLA, basolateral nucleus of the amygdala; CeA, central nucleus of the amygdala; DpMe, deep mesencephalic reticular

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Section: Rem Circuitry: the Pontine Rem Atonia Generatormentioning

confidence: 97%

“…; Yoon & Lee, ; Devera et al . ); (14) REM‐On pathway (Luppi et al . a ); (15) REM‐On pathway (Torterolo et al .…”

Section: Rem Circuitry: the Pontine Rem Atonia Generatormentioning

confidence: 99%

The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep

Arrigoni

Chen

Fuller

2016

The Journal of Physiology

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“…149–152 In the LH, MCH reduces the activity of serotonergic neurons of the DRN. 334 A more complex relationship exists between serotonin in the DRN and orexin. 335 Both are implicated in the regulation of sleep and in the depressive disorders, though there is no direct study of the effects on feeding.…”

Section: Non-homeostatic Control Of Feeding and Activitymentioning

confidence: 99%

Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa

Ross

Mandelblat-Cerf

Verstegen

2016

Harv Rev Psychiatry

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Anorexia nervosa (AN) is a psychiatric illness with minimal effective treatments and a very high rate of mortality. Understanding the neurobiological underpinnings of the disease is imperative for improving outcomes and can be aided by the study of animal models. The activity-based anorexia rodent model (ABA) is the current best parallel for the study of AN. This review describes the basic neurobiology of feeding and hyperactivity seen in both ABA and AN, and compiles the research on the role that stress-response and reward pathways play in modulating the homeostatic drive to eat and to expend energy, which become dysfunctional in ABA and AN.

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“…A wide distribution of MCHR-1 has been identified in the CNS of the rat, which coincides with the distribution of MCHergic fibers (Lembo et al, 1999 ; Saito et al, 2001 ). By a novel approach, utilizing intra-cerebro-ventricular administration of MCH labeled with a fluorescent tag (Rhodamine), Devera et al ( 2015 ) have recently shown in cats and rats that neurons of the DR internalize MCH-rhodamine, indicating that they express receptors for MCH (Figures 3A1,A2 ). In the cat, there is a particularly high density of neurons with MCH receptors surrounding the basal processes of tanycytes within the DR (Devera et al, 2015 ; Figures 3B,C ).…”

Section: The Melanin-concentrating Hormonementioning

confidence: 99%

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression

et al. 2015

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The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, including areas such as the dorsal (DR) and median (MR) raphe nuclei, which are involved in the control of sleep and mood. Major Depression (MD) is a prevalent psychiatric disease diagnosed on the basis of symptomatic criteria such as sadness or melancholia, guilt, irritability, and anhedonia. A short REM sleep latency (i.e., the interval between sleep onset and the first REM sleep period), as well as an increase in the duration of REM sleep and the density of rapid-eye movements during this state, are considered important biological markers of depression. The fact that the greatest firing rate of MCHergic neurons occurs during REM sleep and that optogenetic stimulation of these neurons induces sleep, tends to indicate that MCH plays a critical role in the generation and maintenance of sleep, especially REM sleep. In addition, the acute microinjection of MCH into the DR promotes REM sleep, while immunoneutralization of this peptide within the DR decreases the time spent in this state. Moreover, microinjections of MCH into either the DR or MR promote a depressive-like behavior. In the DR, this effect is prevented by the systemic administration of antidepressant drugs (either fluoxetine or nortriptyline) and blocked by the intra-DR microinjection of a specific MCH receptor antagonist. Using electrophysiological and microdialysis techniques we demonstrated also that MCH decreases the activity of serotonergic DR neurons. Therefore, there are substantive experimental data suggesting that the MCHergic system plays a role in the control of REM sleep and, in addition, in the pathophysiology of depression. Consequently, in the present report, we summarize and evaluate the current data and hypotheses related to the role of MCH in REM sleep and MD.

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Melanin-concentrating hormone (MCH) modulates the activity of dorsal raphe neurons

Cited by 38 publications

References 58 publications

The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep

The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep

Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression

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