Melanin-Dispersing Effect of Adenosine 3″,5″-Monophosphate on Amphibian Melanophores

Novales, Ronald R.; Davis, William J.

doi:10.1210/endo-81-2-283

Cited by 61 publications

(17 citation statements)

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“…We therefore studied the effects of cyclic 3',5'-AMP on the melanophores of this species of another vertebrate class to determine whether the results obtained on amphibian melanophores were of more general significance. The results presented here stand in contrast to those reported earlier for the frog, Rana pipiens (Bitensky & Burstein, 1965;Novales & Davis, 1967).…”

contrasting

confidence: 99%

“…The fact that cyclic 3',5'-AMP can mimic the action of the first-messenger (Sutherland, Robison & Butcher, 1968) is considered strong evidence in support of this hypothesis. The demonstration (Bitensky & Burstein, 1965;Novales & Davis, 1967) that cyclic 3',5'-AMP can mimic the action of MSH on Rana pipiens skin suggests, therefore, that cyclic 3',5'-AMP may possibly play a role in the regulation of melanin granule movement within melanophores. The recent finding (Abe, Butcher, Nicholson, Baird, Liddle & Liddle, 1969) that the darkening of frog skin by MSH is correlated with an increased level of cyclic 3',5'-AMP in the skin is good evidence for its suggested role in MSH action.…”

Section: Discussionmentioning

confidence: 99%

“…beakers containing 10 ml. of Ringer solution (Novales & Davis, 1967). A Photovolt photoelectric reflection meter (Photovolt Corporation, New York, N.Y.) was used to measure the reflectance from each skin.…”

Section: Methodsmentioning

confidence: 99%

“…Butcher & Sutherland, 1967), the concentrations of the nucleotide necessary to disperse melanin granules is quite high (10-2M). Lower concentrations cause little, if any, darkening of skins (Tercafs, 1966;Novales & Davis, 1967).…”

mentioning

confidence: 99%

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Effects of cyclic 3′,5′‐AMP and other adenine nucleotides on the melanophores of the lizard (Anolis carolinensis)

Hadley

Goldman

1969

British J Pharmacology

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. Cyclic 3′,5′‐AMP has been reported to darken skins of the frog, Rana pipiens. This suggests that cyclic 3′,5′‐AMP may mediate the action of MSH on amphibian chromatophores. Since MSH also darkens skins of the lizard, Anolis carolinensis, we investigated the effects of cyclic 3′,5′‐AMP and other nucleotides on Anolis melanophores to determine whether cyclic 3′,5′‐AMP may be the intracellular mediator of hormone action on melanophores of another vertebrate class. . Cyclic 3′,5′‐AMP, itself, causes a rapid melanin granule aggregation within melanophores of Anolis. This response is, however, somewhat nonspecific in that both 5′‐ATP and 5′‐ADP also lighten the skins by aggregating the melanin granules. Another nucleotide, 5′‐AMP, darkens the skins by dispersing melanin granules. Cyclic 2′,3′‐AMP does not darken or lighten Anolis skins. . Dibutyryl cyclic 3′,5′‐AMP, which is considered to be better able to penetrate membranes and resist degradation by a specific phosphodiesterase, maximally darkens Anolis skins, as does MSH. This darkening by the potent dibutyryl cyclic 3′,5′‐AMP suggests that cyclic 3′,5′‐AMP may be the intracellular mediator of melanin granule dispersion within Anolis melanophores leading to skin darkening. . Other evidence supporting the first‐messenger—second‐messenger hypothesis for melanophore regulation is discussed. . The differences in responses of Anolis melanophores to adenine nucleotides may relate to the ability of these agents to penetrate melanophore membranes; thus, the nucleotides could exert their effects either intracellularly or extracellularly on the plasma membrane.

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contrasting

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

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Effects of cyclic 3′,5′‐AMP and other adenine nucleotides on the melanophores of the lizard (Anolis carolinensis)

Hadley

Goldman

1969

British J Pharmacology

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“…Melanocyte-stimulating hormone causes darkening of the frog skin. Theophylline (ABE et aI., 1969), cAMP and dBcAMP (NOVALES and DAVIS, 1967;HADLEY and GOLDMAN, 1969) mimic this effect. Stimulation of p-receptors by isopropylnoradrenaline or by salbutamol also causes darkening of the skin (GOLDMAN and HADLEY, 1969a and b).…”

Section: E) Frog Skinmentioning

confidence: 91%