Melanocortins and cardiovascular regulation

Versteeg, Dirk H.G.; Bergen, P. Van; Adan, Roger A.H.; Wildt, Dick J. De

doi:10.1016/s0014-2999(98)00615-3

Cited by 91 publications

(73 citation statements)

References 82 publications

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“…Melanocortins influence cardiovascular circuits (Versteeg et al, 1998), and the correlation between obesity and high blood pressure suggest that melanocortinergic neurotransmission within NTS provides a link between energy and cardiovascular homeostatic circuits (Appleyard et al, 2005). …”

Section: Implications For the Control Of Food Intakementioning

confidence: 99%

Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

Wan¹,

Browning²,

Coleman³

et al. 2008

J. Neurosci.

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Section: Implications For the Control Of Food Intakementioning

confidence: 99%

Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

Wan¹,

Browning²,

Coleman³

et al. 2008

J. Neurosci.

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“…NTS POMC-EGFP neurons may receive information from these additional sensory afferents and participate in neuronal circuits widely influencing autonomic functions. Interestingly, melanocortins, opioids, and CCK all modulate heart rate and blood pres-sure (Versteeg et al, 1998;Bodnar and Hadjimarkou, 2002;Verberne et al, 2003). Given the epidemiological relationship between obesity and hypertension, NTS POMC-EGFP neurons could provide a bridge between cardiovascular and energy homeostatic regulatory pathways.…”

Section: Role Of Nts Pomc-egfp Neurons In the Regulation Of Other Autmentioning

confidence: 99%

Proopiomelanocortin Neurons in Nucleus Tractus Solitarius Are Activated by Visceral Afferents: Regulation by Cholecystokinin and Opioids

et al. 2005

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“…Three forms of ␥-MSH have been identified: ␥ 1 -MSH has 11 amino acids with a COOH-terminal amidation, ␥ 2 -MSH is identical to ␥ 1 -MSH but with a COOH-terminal glycine added, and ␥ 3 -MSH has an additional COOH-terminal extension of 13 amino acids; these structural differences have been suggested to underlie differing actions of the ␥-MSH peptides (10,31,34). MSH peptides exert their functions by interacting with a family of five transmembrane melanocortin receptors, termed MC1-R to MC5-R, which are linked to adenylate cyclase and possibly other signaling mechanisms (9,28,31,34). Of the five MC-Rs, ␥-MSH has the highest affinity for MC3-R, and it is likely the natural ligand for this receptor (27).…”

mentioning

confidence: 99%

Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney

Bhargava

Pearce

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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-␥-Melanocyte stimulating hormone (␥-MSH) is a circulating natriuretic peptide hormone derived from proopiomelanocortin (POMC); its concentration in plasma and pituitary POMC mRNA abundance, increase in rats ingesting a high-sodium diet (HSD, 8% NaCl) compared with a low-sodium diet (LSD, 0.07% NaCl). RT-PCR of rat kidney RNA demonstrated reaction products of the expected size in both cortex and medulla for MC3-R, MC4-R, and MC5-R mRNA; no signal for MC1-R or MC2-R was detected. Relative to ␤-actin or cyclophilin, abundance of the three receptor transcripts after 1 wk of the LSD was approximately equal in both cortex and medulla. After 1 wk of the HSD, mRNA abundance of MC4-R and MC5-R was unchanged, whereas that of MC3-R in medulla more than doubled, the ratio of MC3-R/␤-actin signal increasing from 0.38 Ϯ 0.04 on LSD to 0.84 Ϯ 0.04 on HSD (P Ͻ 0.001). No significant increase occurred in the cortex. The increase in MC3-R expression induced by dietary sodium was observed in inner medullary collecting duct (IMCD) cells isolated from the kidneys of HSD rats, suggesting that these cells were the major site of receptor expression in the medulla. Immunoblots of whole medullary and IMCD cell homogenates detected MC3-R immunoreactive protein; its expression was twice as great in samples from HSD vs. LSD rat kidneys, paralleling the increase in MC3-R mRNA abundance on the HSD. No changes in MC4-R or MC5-R protein expression were observed. Incubation of IMCD cell suspensions with increasing concentrations of ␥ 2-MSH led to increased cAMP accumulation, with values from rats on the HSD being roughly double the values from LSD rats. Intrarenal infusion of ␥ 2-MSH (500 fmol/min) increased sodium and cAMP excretion from the infused but not contralateral kidney of HSD rats, while having no effect in LSD rats. These data show that MC3-R is expressed in rat IMCD cells in a manner modulated by dietary sodium intake. Because MC3-R is the receptor with which ␥-MSH interacts, our findings suggest the existence of a sodium-regulating system, activated in response to a HSD, which increases urinary sodium excretion to balance the high-sodium intake.␥-melanocyte stimulating hormone; sodium excretion; inner medullary collecting duct; peptide hormone; sodium balance; cyclic AMP ⌫-MELANOCYTE STIMULATING HORMONE (␥-MSH) is a natriuretic peptide derived, like ␣-and ␤-MSH, from processing of proopiomelancortin (POMC) in the pituitary intermediate lobe (IL) from which it is secreted into the circulation (1, 9, 29). Three forms of ␥-MSH have been identified: ␥ 1 -MSH has 11 amino acids with a COOH-terminal amidation, ␥ 2 -MSH is identical to ␥ 1 -MSH but with a COOH-terminal glycine added, and ␥ 3 -MSH has an additional COOH-terminal extension of 13 amino acids; these structural differences have been suggested to underlie differing actions of the ␥-MSH peptides (10,31,34). MSH peptides exert their functions by interacting with a family of five transmembrane melanocortin receptors, termed MC1-R to MC5-R, which are linked to adenylate cyclase and...

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Melanocortins and cardiovascular regulation

Cited by 91 publications

References 82 publications

Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

Proopiomelanocortin Neurons in Nucleus Tractus Solitarius Are Activated by Visceral Afferents: Regulation by Cholecystokinin and Opioids

Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney

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