Melanocyte Pygmentation – Friend or Foe on the Route to Melanoma

Bâldea, Ioana

doi:10.5772/20157

Cited by 2 publications

(2 citation statements)

References 223 publications

(247 reference statements)

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“…The variations in human skin inducible pigmentation by UVR are partially due to the existence of the redhead/MC1-R allele. Epidemiologically, there is a strong association between MC1-R loss-of-function allele and the risk for malignant transformation of epidermal melanocytes, suggesting that MC1-R functions as a melanoma susceptibility gene [65].…”

Section: Melanogenesismentioning

confidence: 99%

Current position of TNF-α in melanomagenesis

et al. 2015

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Melanoma is one of the most heterogeneous and immunogenic forms of cancer. Both tumor and stroma cells synthesize many cytokines involved in rapid development and metastasis. One of these cytokines from the tumor milieu is tumor necrosis factor-alpha (TNF-α), which seems to have an intricate role in melanomagenesis. Initially, it was found that TNF-α can induce apoptosis of tumor cells through both extrinsic and intrinsic pathways, in contrast with later studies that revealed its protumoral activity. TNF-α is involved in inflammation, inducing the secretion of survival molecules like antiapoptotic proteins, proangiogenetic factors and metastasis markers. Although there are many therapeutic strategies against melanoma, the prognosis of advanced stages remains poor, due to several tumor resistance mechanisms. TNF seems to be a negative prognostic factor in melanoma surgery and correlates with chemotherapy resistance. However, high intratumoral levels of TNF-α might be beneficial for immunotherapy. Researchers may redirect their studies in the future by double activating of the proinflammatory molecule TNF-α and the immune cells in order to obtain an antitumoral response in metastatic melanoma.

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Section: Melanogenesismentioning

confidence: 99%

Current position of TNF-α in melanomagenesis

et al. 2015

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“…22 shows melanoma from the pigmented control group. Besides the cells characteristic, melanin is also observed within the entire the tumor.…”

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confidence: 99%

Optical strategies for diagnosis and treatment of melanoma

Pires¹

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I thank my labmate fellows at UHN for the stimulating discussions and support during my internship abroad. I am particular grateful to Carl, Santa, Masood, Greg, Azusa, and Valentin. I really appreciate the time I spent with you guys. I take this opportunity to express gratitude to all my friends from the Biophotonics lab, especially the ones involved in this thesis: Clovis, Sebastião, Renan and Lili. Thanks to you all! I must thank my friends with whom I shared the "Castle" office the last years. Cintia, Mariana, Michelle, Mirian, Thereza, and Didi, I couldn't have asked for best friends. I am grateful for the funding sources that allowed me to develop this project: Coordination for the Improvement of Higher Level Personnel-Capes, Council of Scientif and Technological Development (CNPq)-Science Without Borders Program and 305795/2016-3, UofT-USP joint project, FAPESP (Cepof-2013/07276-1) and Princess Margaret Cancer Foundation. "What we do for ourselves dies with us. What we do for others and the world remains and is immortal."

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Melanocyte Pygmentation – Friend or Foe on the Route to Melanoma

Cited by 2 publications

References 223 publications

Current position of TNF-α in melanomagenesis

Current position of TNF-α in melanomagenesis

Optical strategies for diagnosis and treatment of melanoma

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