Melanocyte-Stimulating-Hormone Levels in Doxorubicin-Induced Hyperpigmentation

Kew, M. C.; Mzamane, Dume; Smith, A G; Shuster, Sam

doi:10.1016/s0140-6736(77)93006-9

Cited by 26 publications

(8 citation statements)

References 6 publications

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“…It has been speculated that suppression of adrenal function by doxorubicin may cause an excess of melanocyte-stimulating hormone (MSH) by the pituitary gland. However, serum MSH and plasma cortisol levels have been reported to be normal (9). Plasma cortisol and a-MSH levels in the present patient were also normal.…”

Section: Discussioncontrasting

confidence: 44%

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Blue‐gray Pigmentation in a Patient Receiving Doxorubicin

Konohana

1992

The Journal of Dermatology

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Section: Discussioncontrasting

confidence: 44%

“…The commonest site is the nails (1-4). It can also develop on the palms and soles (5,6), tongue (6,7), buccal mucosa (5) or face (9). Total body pigmentation has also been reported (4).…”

Section: Discussionmentioning

confidence: 99%

Blue‐gray Pigmentation in a Patient Receiving Doxorubicin

Konohana

1992

The Journal of Dermatology

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“…In general, cancer chemotherapy-induced hyperpigmentation is independent of adrenocorticotrophic hormone (ACTH) and melanocyte stimulating hormone (MSH) activity (11,12). The level of these hormones after 5-FU administration was not measured.…”

Section: Electron Microscopic Findingsmentioning

confidence: 99%

Pigmented Macules in Patients Treated with Systemic 5‐Fluorouracil

Cho

Chung

Lee

et al. 1988

The Journal of Dermatology

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Pigmented macules were observed in 72 (52.6%) out of 137 patients treated with systemic 5‐fluorouracil. These pigmented macules usually appeared on the palms and the soles. Their incidence seemed to be proportional to the number of chemotherapy cycles. Histological studies showed a slight increase in melanin pigmentation in the epidermis without any change in the melanocyte number. This suggests that the melanocytes already present produced quantities of melanin.

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“…An isolated elevation of MSH is unlikely to occur, however, since ß-lipotropin, which contains MSH, and corticotropin are nearly always secreted in parallel.8 Fur¬ thermore, in the only two cases of doxorubicin-induced nail banding in which MSH was assayed, neither a-nor /3-MSH levels were elevated. 6 The distribution and hyperemic appearance of the hyperpigmentation in the patient we describe suggests that daunorubicin may increase the response of melanocytes to UV radiation. That the reaction involved chiefly exposed areas of skin and occurred during the summer in a subtropical region also support the possibility that the drug altered the patient's photosensitivity.…”

Section: Commentmentioning

confidence: 65%