2005
DOI: 10.1016/j.exer.2005.01.023
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Melanocytes in the corneal limbus interact with K19-positive basal epithelial cells

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Cited by 91 publications
(75 citation statements)
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“…The limbal areas are rich in melanin pigments, highly innervated, well-vascularised and have a different array of extracellular matrix components than the central epithelium. Melanocytes or melanin granules within the cytoplasm of progenitor cells are thought to play a role in protection against ultraviolet radiation [8,72] . Blood-derived growth factors and nutrients provide for the active cell division [8,73] .…”
Section: Centripetal Migrationmentioning
confidence: 99%
“…The limbal areas are rich in melanin pigments, highly innervated, well-vascularised and have a different array of extracellular matrix components than the central epithelium. Melanocytes or melanin granules within the cytoplasm of progenitor cells are thought to play a role in protection against ultraviolet radiation [8,72] . Blood-derived growth factors and nutrients provide for the active cell division [8,73] .…”
Section: Centripetal Migrationmentioning
confidence: 99%
“…Before functional dimension can be addressed, it is necessary to understand where the limbal niche is. Anatomically, the limbal SC niche is located at the Palisades of Vogt (Figure 1), which is highly pigmented because of melanocytes [49][50][51], and is infiltrated with antigen-presenting Langerhan's cells [52] and suppressor T-lymphocytes [53]. Unlike that of the cornea, the basement membrane of the limbus is undulating with papillae or 'pegs' of stroma extending upward [54] and fenestrated [55,56]; these anatomic features in the limbus suggest that limbal epithelial SCs might closely interact with cells in the underlying limbal stroma (Figure 2).…”
Section: Where Is the Limbal Stem Cell Niche?mentioning
confidence: 99%
“…In this regard, melanocytes, distributed in the limbal basal layer with their cellular projections extending to surrounding basal epithelial cells [51], may be one candidate of niche cells ( Figure 2). These cells produce and transport melanin pigments into epithelial cells so as to minimize damage caused by ultraviolet irradiation, a presumed action similarly described in the SC-containing bulge area of the human skin [65].…”
Section: Conjunctivamentioning
confidence: 99%
“…In the basal layers of the interpalisade rete ridges, small, round cells, exhibiting morphological features of primitive stem cells were shown (16,38,100,101). Protection of stem cells is thought to be fulfilled by three attributes of the palisades: they are situated in those parts of the cornea that are most protected by the eyelids; they contain melanocytes that safeguard stem cells from UV radiation by the transfer of melanin granules (35,38,102,103); in addition, protection from mechanical shear forces is provided at the bottom of the rete pegs. The palisade ridge regions contain blood vessels that can provide nutrients and other supportive factors for the SCs (1,39,58,101).…”
Section: The Limbal Epithelial Stem Cell Nichementioning
confidence: 99%