Melanocytic Naevi and Melanoma

Newton-Bishop, Julia

doi:10.1002/9781444345384.ch109

Cited by 5 publications

(6 citation statements)

References 169 publications

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“…The focus can have circular or ovoid contours and is flat initially, and pigmentary intensity may diminish during the first year. 6 Approximately 1% to 2% of neonates have a CMN, but one study has reported that almost 25% of newborns have congenital or prenatal nevi; 10 these lesions may be solitary (most cases), multiple, or confluent which in some respects correlates with size: small (<1.5 cm), medium (1.5–19.9 cm), and giant (≥20 cm). The size of a CMN is a projected one at adulthood with the use of multipliers.…”

Section: Congenital Melanocytic Nevusmentioning

confidence: 99%

“…Some of these include pigmentary features of the individual, geographic latitude, low versus high altitude, and family history of MM. 4,6 There is also a correlation with the number of AMNs, sun exposure, and the risk of melanoma. Among white children, the mean nevus count is 15 to 30, and in darker skin children, it is 5 to 10 nevi by the end of the first decade when the greatest accumulation of AMNs occurs.…”

Section: Acquired Melanocytic Nevusmentioning

confidence: 99%

“…Halo nevi occur most commonly in adolescents, and there is a predilection for the trunk. 4,6 Because a nevus has a clinical halo, there is no reason to be especially concerned since most of these lesions are compound melanocytic nevi. 56…”

Section: Acquired Melanocytic Nevusmentioning

confidence: 99%

“…The archetype of the Spitz nevus in a child is a solitary amelanotic flesh-colored, well-circumscribed papule or nodule, typically measuring 1 cm or less. 4,6,80 The prominent vascularity in the suprapapillary/papillary dermis can convey the clinical impression of a pyogenic granuloma. When pigmentation is present, it is generally modest in degree in contrast to the dense coloration of the spindle cell nevus of Reed.…”

Section: Acquired Melanocytic Nevusmentioning

confidence: 99%

“…The classification of melanocytic lesions in children is essentially no different than the one applied to those which come to clinical attention in adults. 6 A tabulation of the various melanocytic lesions submitted to our dermatopathology laboratory during the period from 2012 to 2016 from children and adolescents is available in Table 1. Approximately 1% of the compound melanocytic nevi were congenital in type based upon the histologic features.…”

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confidence: 99%

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Common and not so Common Melanocytic Lesions in Children and Adolescents

2018

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The acquired melanocytic nevus is the most common lesion encountered by pediatric pathologists and dermatopathologists in their daily practice. In most cases, there are few difficulties in histopathologic diagnosis. However, it is the acquired melanocytic lesion known as the Spitz nevus, with its intrinsic atypical features which becomes the challenge since it exists along a histopathologic and biologic continuum from the atypical Spitz tumor to spitzoid melanoma. The frustration with some of these spitzoid lesions is that even the "experts" cannot agree as to the differentiation of one from the other even at the level of molecular genetics. Other melanocytic lesions are discussed including the congenital melanocytic nevus with its proliferative nodule(s) and melanoma as the ultimate complication. Although uncommon, cutaneous melanoma in the first 2 decades is emerging as a clinical problem especially in young women in the second decade of life. These are ultraviolet-associated neoplasms whose histopathologic and prognostic features are identical to the adult experience. Considerable progress has been made over the past 15 to 20 years in our understanding of cutaneous melanocytic lesions, but gaps still exist in the important group of spitzoid lesions. It can also be anticipated that more cutaneous melanomas in children will be seen in the future based upon epidemiologic studies.

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Section: Congenital Melanocytic Nevusmentioning

confidence: 99%

Section: Acquired Melanocytic Nevusmentioning

confidence: 99%

Section: Acquired Melanocytic Nevusmentioning

confidence: 99%

Section: Acquired Melanocytic Nevusmentioning

confidence: 99%

mentioning

confidence: 99%

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Common and not so Common Melanocytic Lesions in Children and Adolescents

2018

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Manchas Mongólicas Múltiplas e Sobrepostas numa Criança Caucasiana

António

Costin

Cunha

2018

SPDV

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RESUMO -A mancha mongólica é uma forma de melanose dérmica comum em recém-nascidos, tendo uma incidência e prevalência variável consoante a raça, sendo menos frequente em crianças caucasianas. Apesar de tradicionalmente interpretadas como benignas, várias publicações têm vindo a sugerir que manchas mongólicas extensas, múltiplas, presentes em locais atípicos e persistentes ao longo da primeira infância podem estar associadas a algumas doenças metabólicas. Contudo, esta associação não está ainda bem esclarecida. Por outro lado, casos pontuais reportados na literatura têm descrito um tipo particular de mancha mongólica sobreposta a outra de pigmentação diferente, não sendo conhecido o mecanismo fisiopatológico e a relevância clínica deste achado. Os autores reportam o caso de um rapaz caucasiano com 7 meses de idade com manchas mongólicas múltiplas, extensas, de agravamento progressivo nos primeiros meses de vida, uma das quais mais pigmentada sobreposta a outra, localizada na anca direita. PALAVRAS-CHAVE -

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