Mélanocytome méningé: évolution agressive d’une tumeur bénigne: à propos de 2 cas

Khoulali, Mohamed; Haouas, Mohammed Yasssine; Mortada, Jihad; Srour, Robin

doi:10.11604/pamj.2018.29.211.10680

Cited by 1 publication

(2 citation statements)

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“…Such tumors may evolve from a long time malignant transformation to a rapid massive meningeal diffusion. [ 18 ] On the whole, these tumors are considered a good prognosis even though they can be locally aggressive or transform into malignant tumors. [ 19 ] Therefore, it is crucial to reach a rapid diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…This case report is the first about a patient with meningeal melanocytoma treated with immunotherapy. Such tumors may evolve from a long time malignant transformation to a rapid massive meningeal diffusion [18] . On the whole, these tumors are considered a good prognosis even though they can be locally aggressive or transform into malignant tumors [19] .…”

Section: Discussionmentioning

confidence: 99%

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Nivolumab as adjuvant treatment for a spinal melanocytoma

et al. 2021

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Rationale: Meningeal melanocytoma is a rare benign melanocytic tumor of the central nervous system. We report for the first time a case of meningeal melanocytoma treated with immunotherapy. Patient concerns: A 70-year-old man with no medical history was admitted to the Emergency Room. He suffered from a motor and sensory deficit in his left lower limb and a bilateral upper arm neuralgia. Diagnoses: A contrast-enhanced magnetic resonance imaging (MRI) was performed. It showed a C7-T1 bleeding intramedullary tumor. Laminectomy was decided and performed. The results of the pathologic examination showed a melanocytic tumor harboring GNAQ mutation. Meningeal melanocytoma was the final diagnosis. Interventions: The patient was treated with 10 radiotherapy sessions and 6 cycles of nivolumab. A year later, the patient experienced neuralgia again with severe pain and an increasing sensory motor deficit. He underwent a second surgery that was incomplete. As the tumor kept growing, he received temozolomide. But the 6th cycle had to be interrupted due to bedsore infection in the hip area. Outcomes: Disease progression finally led to the patient's death 3 years after diagnosis. Lessons: This case report is the first about a patient with meningeal melanocytoma treated with immunotherapy. Treatment based on biomolecular mutations will probably change spinal melanocytoma therapeutic approach in the next few years.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%