Melanogenesis inhibitory activity of a 7-O-9′-linked neolignan from Alpinia galanga fruit

Melanogenesis‐Inhibitory and Cytotoxic Activities of Chemical Constituents from the Leaves of Sauropus androgynus L. Merr. (Euphorbiaceae)

“…This study has established that the MeOH extract of S. androgynus leaves contains nucleosides, terpenoids, flavonoid glycosides, along with other compounds including steroids as active principles which exhibited cytotoxic activity against HL60, AZ521, SKBR3, and A549 four human cell lines, as well as have been demonstrated to be the relevant active principles of the extract. Moreover, the results also revealed that the flavonoid glycosides exhibited superior capacities to melanogenesis‐inhibitory, because of the structure activity relationship investigation revealed that the flavone skeleton and/or phenolic hydroxy groups, which had been reported in recent literature . This study has thus demonstrated that the MeOH extract of S. androgynus leaves and its constituents may also be valuable as potential anticancer agents and skin‐whitening agents.…”

Chemical Constituents and Bioactivities of Several Indonesian Plants Typically Used in Jamu

“…Compounds 65, 67 and 66 displayed moderate cytotoxic activity, with IC 50 values of 11.9, 12.6 and 13.3 µg/mL, respectively, whereas 13 presented the strongest inhibitory activity, with an IC 50 value of 9.1 µg/mL. 31) Two novel Guaiane-type sesquiterpenes, zedoaraldehyde (69) and zedoardiol (70), together with known 41, 57, gweicurculactone (71), 13-hydroxygermacrone (72), 33) gelchomanolide (73), 34) 8β-hydroxy-isogermafurenolide (74), 35) 3-hydroxy-6-methylacetophenone (75), 36) and dehydro-6-gingerdione (76) were isolated from this plant (Fig. 2).…”

“…As an additional note, the efficacy of antibiotic resistance treatment by a crude acetone extract of Alpinia galanga was detected in S. typhi and E. coli, and was higher compared to 1′-acetoxychavicol acetate. 69) The acetone extract of Alpinia galanga dried fruit inhibited melanogenesis in theophylline-stimulated murine B16 in melanoma 4A5 cells, with an IC 50 value of 7.3 µg/mL. The EtOAc fraction of this extract yielded new galanganol D diacetate (228, 0.00292%), together with 10S-10-acetoxychavicol acetate (229, 0.0977%), 10S-10-acetoxyeugenol acetate (230, 0.119%), 10S-10-hydroxychavicol acetate (231, 0.00430%), 10S-10-hydroxyeugenol acetate (232, 0.0675%), 10S-10-acetoxydihydrochavicol acetate (233, 0.00028%), 1-(4-hydroxyphenyl)-1-propanone (234, 0.00024%), trans-p-coumaryl acetate (235, 0.00140%), trans-p-acetoxycinnamoyl alcohol (236, 0.00162%), trans-p-coumaryl alcohol (237, 0.00168%), trans-p-coumaryl aldehyde (238, 0.00026%), trans-p-coumaryl alcohol C-Omethyl ether (239, 0.00131%), trans-coniferyl alcohol 4-O-acetate (240, 0.00041%), trans-coniferyl alcohol (241, 0.00869%), and trans-coniferyl aldehyde (242, 0.00036%) 70) (Fig.…”

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“…Plants of genus Alpinia have been widely used for different purposes. For instance, Alpinia galangal Willd is an important ingredient for curries, used to preserve food and fruits and use as a flavoring agent 10 , in the preparation of meats and soups in Southeast Asia and the preparation of beverages in Europe 11 ; Alpinia vittata, Alpinia purpurata, Alpinia calcarata, and Alpinia zerumbet are cultivated as ornamental plants 12 ; Alpinia blepharocalyx is a natural dye 13 and Alpinia officinarum used in medicinal diets 13 ; wines 14 ; sauces and flavorings 15 . Moreover, Alpinia plants are broadly utilized as traditional medicines in India, China, and Japan to treat many diseases such as indigestion, gastralgia, vomiting, etc.…”