Melanoma affinity in mice and immunosuppressed sheep of [125I]N-(4-dipropylaminobutyl)-4-iodobenzamide, a new targeting agent

Labarre, P.; Papon, Janine; Rose, Alison H.; Guerquin‐Kern, Jean‐Luc; Morandeau, Laurence; Wu, Ting-Di; Moreau, Marie-France; Bayle, Martine; Chezal, Jean‐Michel; Croisy, Alain; Madelmont, Jean‐Claude; Turner, Harvey; Moins, Nicole

doi:10.1016/j.nucmedbio.2008.07.003

Cited by 12 publications

(3 citation statements)

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“…NanoSIMS is therefore well suited for imaging trace quantities of elements in a complex biological environment for elucidating metabolic pathways of living systems. Taking advantage of the high sensitivity, NanoSIMS has been also applied in numerous isotope tracer studies, for example, for studying the incorporation of iodine in thyroid, , the cellular distribution of melanoma targeting agents, iodobenzamide, , and the uptake of 131 I-labeled drugs in melanoma for developing a targeted radionuclide therapy . The improved spatial resolution and sensitivity of nanoSIMS enabled imaging of uptake of isotopically labeled compounds in bacterial cells − and diatoms , at the single-cell level in order to understand microbial metabolism and to identify associated subcellular structures .…”

Section: Mass Spectrometry Imaging Techniquesmentioning

confidence: 99%

In Situ Imaging of Metals in Cells and Tissues

et al. 2009

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Section: Mass Spectrometry Imaging Techniquesmentioning

confidence: 99%

In Situ Imaging of Metals in Cells and Tissues

et al. 2009

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“…We demonstrated that the two compounds exhibited similar in vitro cellular uptake kinetics, and based Labarre et al reported the in vitro radiotoxic properties of another benzamide derivative, BZ18, described as a melanoma carrier with only an intracellular melanin binding site. Higher concentrations of [ 125 I]BZ18 are needed to obtain a radiotoxicity [35]. The stronger radiotoxicity delivered by [ 125 I]ICF01035 (factor 25) and by [ 125 I]ICF01040 (factor 100) could be explained by internalization of ICF01035 and ICF01040 in close vicinity to the nucleus.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using 125I, an Auger electron emitter

et al. 2010

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The increasing incidence of melanoma and the lack of effective therapy on the disseminated form have led to an urgent need for new specific therapies. Several iodobenzamides or analogs are known to possess specific affinity for melanoma tissue. New heteroaromatic derivatives have been designed with a cytotoxic moiety and termed DNA intercalating agents. These compounds could be applied in targeted radionuclide therapy using (125)I, which emits Auger electrons and gives high-energy, localized irradiation. Two iodinated acridine derivatives have been reported to present an in vivo kinetic profile conducive to application in targeted radionuclide therapy. The aim of the present study was to perform a preclinical evaluation of these compounds. The DNA intercalating property was confirmed for both compounds. After radiolabeling with (125)I, the two compounds induced in vitro a significant radiotoxicity to B16F0 melanoma cells. Nevertheless, the acridine compound appeared more radiotoxic than the acridone compound. While cellular uptake was similar for both compounds, SIMS analysis and in vitro protocol showed a stronger affinity for melanin with acridone derivative, which was able to induce a predominant scavenging process in the melanosome and restrict access to the nucleus. In conclusion, the acridine derivative with a higher nuclear localization appeared a better candidate for application in targeted radionuclide therapy using (125)I.

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“…The uptake and intracellular distribution of new melanoma targeting agents have been studied using a NanoSIMS 50 instruments for imaging. [220][221][222] The colocalization of 127 I À secondary ions originating from the targeting agent with 32 S À and 26 CN À secondary ions related to cellular structures 220,221 and melanin in the melanosome, 222 respectively, demonstrates a significant accumulation of the target agent in melanosomes. The same method has been used to investigate the cellular uptake of an iodine-labelled antitumor agent into different types of human tumor cells.…”

Section: Medical Researchmentioning

confidence: 99%

SIMS imaging of the nanoworld: applications in science and technology

Senoner

Unger

2012

J. Anal. At. Spectrom.

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Secondary Ion Mass Spectrometry (SIMS) enables surface chemical analysis of nano-scaled objects and chemical imaging of nano-scaled details of natural or artificial objects. This review presents the state of the art in nanoscale SIMS analysis. At first a short introduction into recent instrumentation for high resolution SIMS imaging and the limiting factors of lateral resolution is given. The next section covers the chemical analysis of nanoparticles. Recent applications of nanoscale imaging SIMS in geology, cosmochemistry, materials research, cellular biology, ecology and medical research are summarized and illustrated by examples.

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Melanoma affinity in mice and immunosuppressed sheep of [125I]N-(4-dipropylaminobutyl)-4-iodobenzamide, a new targeting agent

Cited by 12 publications

References 20 publications

In Situ Imaging of Metals in Cells and Tissues

In Situ Imaging of Metals in Cells and Tissues

Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using 125I, an Auger electron emitter

SIMS imaging of the nanoworld: applications in science and technology

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