Melanoma Among Non-Hispanic Black Americans

Culp, MaryBeth; Lunsford, Natasha Buchanan

doi:10.5888/pcd16.180640

Cited by 38 publications

(57 citation statements)

References 24 publications

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“…38 Caucasians present more with in situ and PAD with distant disease. 5,9,14 The prevalence of in situ disease varies from 29.7% to 78% in Caucasians compared to 12.1% to 55% in PAD. Distant disease varies from 2.3% to 5% in Caucasians and 7.5% to 16% in PADs.…”

Section: Risk Factorsmentioning

confidence: 99%

“…These differences include; anatomical sites, stage at presentation, ulceration and lymph node involvement. At diagnosis, Caucasians present more with in situ and PAD with distant disease 5,9,14 . The prevalence of in situ disease varies from 29.7% to 78% in Caucasians compared to 12.1% to 55% in PAD.…”

Section: Clinicalmentioning

confidence: 99%

“…People of African descent have also been found to be less aware of their risk for and the clinical features of CM compared to Caucasians 13 . The result of this is advanced disease presentation and poor melanoma specific survival in PAD 6,14,15 …”

Section: Introductionmentioning

confidence: 99%

“…13 The result of this is advanced disease presentation and poor melanoma specific survival in PAD. 6,14,15 Studies of cutaneous melanoma (CM) in individuals living in Africa are few due to the rarity of the disease. The few studies that have been conducted show melanoma as the cause of skin cancer in 31% of cancers from Cotonou, 16 9.9% and 37.8% in Nigeria, 17,18 7.5% in South Africa 19 and 0% in Togo (study from 1984 to 2008).…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of cutaneous melanoma and its associated issues between people of African decent and Caucasians

Anaba

2021

Dermatologic Therapy

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Cutaneous melanoma is uncommon in people of African descent unlike their Caucasian counterparts. This rarity of cutaneous melanoma in people of African descent makes studies in this group difficult. In the few studies that are available, several differences exist in the incidence, disease severity, course of the disease, treatment modalities and survival rates between these two groups. Observed difference in cutaneous melanoma between people of African descent and Caucasians include; a higher incidence and better prognosis in Caucasians, a low awareness of melanoma, no definite risk factors, presentation with advanced disease, poor melanoma specific survival in people of African descent. Other differences are a better UV-induced DNA damage recovery, acral as opposed to truncal melanoma, female preponderance and lack of preventive measures in people of African descent.

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Section: Risk Factorsmentioning

confidence: 99%

Section: Clinicalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative study of cutaneous melanoma and its associated issues between people of African decent and Caucasians

Anaba

2021

Dermatologic Therapy

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“… 3 However, stage, age, and race showed significantly shorter survival for black patients than their white counterparts, with acral lentiginous melanoma being most common in NHB patients. 3 , 4 According to the United States Census Bureau, Wayne County, Michigan, has a population of 1,749,343 and a 19.8% poverty rate, compared to the 10.5% national rate. 5 The entire county has a NHW population of 54.6% and a NHB population of 38.7%.…”

Section: Introductionmentioning

confidence: 99%

Racial Disparities in Patients with Melanoma: A Multivariate Survival Analysis

Brady¹,

Kashlan²,

Ruterbusch³

et al. 2021

CCID

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Purpose: As the most common cause of skin cancer death, incidence and mortality of melanoma vary widely between ethnic and racial groups. Methods: Surveillance, Epidemiology, and End Results (SEER) data were used to examine the incidence and survival in patients with melanoma concerning race and ethnicity in Wayne County, Michigan between 2000 and 2016. Results: Analysis of data revealed significantly higher melanoma-specific death in non-Hispanic black patients compared to their non-Hispanic white counterparts (p <0.001). However, no increased risk of death due to melanoma was observed following adjustment of data for the stage, age, and sex (H.R. = 1.00, 95% CI 0.64-1.56). Conclusion: Non-Hispanic black patients have the highest percentage of late-stage melanoma. Increased incidence of melanoma mortality in non-Hispanic black patients is likely a consequence of late-stage diagnosis.

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Clinical Features and Outcomes of Black Patients With Melanoma

Wix,

Brown,

Heberton

et al. 2024

JAMA Dermatol

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ImportanceMelanoma in Black individuals has an annual incidence of approximately 1 in 100 000 people. Most studies of melanoma in Black patients have used population databases, which lack important, precise clinical details.ObjectiveTo identify patient-level and tumor-level characteristics of melanoma in Black patients.Design, Setting, and ParticipantsThis case series included Black patients with melanoma at 2 tertiary care centers (University of Texas Southwestern [UTSW] Medical Center and Parkland Health), affiliated with a single institution, UTSW in Dallas, Texas. Self-reported Black patients with a histopathologic diagnosis of melanoma were identified between January 2006 and October 2022.Main Outcomes and MeasuresThe main variables were demographics, clinical characteristics, personal and family medical history, immunosuppression history, comorbidities, histopathology reports, molecular/genetic studies, imaging reports, melanoma treatments and responses, time to progression, metastatic sites, and survival rates.ResultsA total of 48 Black patients with melanoma (median [range] age at diagnosis, 62 [23-86] years; 30 [63%] female) were included in the study. Of 40 primary cutaneous melanomas, 30 (75%) were located on acral skin, despite only 10 of 30 (33%) being histologically classified as acral lentiginous melanomas. Compared with those with acral disease, patients with nonacral cutaneous melanomas were more likely to be immunocompromised (4 of 10 [40%] vs 2 of 30 [7%]) or have a personal history of cancer (6 of 10 [60%] vs 5 of 30 [17%]), with all 3 patients with superficial spreading melanoma having a history of both. No patients had more than 1 confirmed primary melanoma. Overall, 13 Black patients (27%) with melanoma developed stage IV disease, of whom 12 died because of disease progression. Those diagnosed with advanced acral melanoma, mucosal/ocular melanoma, or melanoma of unknown primary lacked actionable sequence variations, were nonresponsive to immunotherapy, and had the poorest outcomes. No patients with nonacral cutaneous melanomas developed distant metastases or died of melanoma.Conclusions and RelevanceThis single-institution case series highlights several features of melanoma in Black patients that have not been captured in existing population-level registries, including precise anatomic sites, immune status, family and personal cancer history, and genetics. Multi-institutional registries would improve understanding of melanoma in Black patients.

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Melanoma Among Non-Hispanic Black Americans

Cited by 38 publications

References 24 publications

Comparative study of cutaneous melanoma and its associated issues between people of African decent and Caucasians

Comparative study of cutaneous melanoma and its associated issues between people of African decent and Caucasians

Racial Disparities in Patients with Melanoma: A Multivariate Survival Analysis

Clinical Features and Outcomes of Black Patients With Melanoma

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