Melanoma and obesity: Should antioxidant vitamins be addressed?

Oliveira, Sofia Castro; Coelho, Pedro; Prudêncio, Cristina; Vieira, Mónica; Soares, Raquel; Guerreiro, Susana G.; Fernandes, Rúben

doi:10.1016/j.lfs.2016.09.015

Cited by 5 publications

(12 citation statements)

References 92 publications

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“…They may experience high incidence or prevalence rate owing to the earlier detection and upgraded medical technology. There is some evidence showing that the cause of these variations may arise from the disparities in many factors, like level of education and completeness of ascertainment of melanoma, as well as disparities of the quality of screening and medical care and economic development by provinces, and even the lifestyle and metabolic risk factors, like obesity, dietary factors and alcohol intake . As solar ultraviolet radiation is important in melanoma etiology, we believe the disparities of ultraviolet exposure play a major role in the differences of the DALYs from melanoma among the provinces.…”

Section: Discussionmentioning

confidence: 93%

Burden of melanoma in China, 1990–2017: Findings from the 2017 global burden of disease study

Wang

et al. 2019

Intl Journal of Cancer

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Melanoma is an aggressive form of skin cancer, and a worldwide problem with increasing incidence. Little is known about the burden of melanoma in the Chinese population. We evaluated temporal trends and geographic variation in melanoma‐associated burden, to narrow an important knowledge gap concerning the consequences of this disorder across time, provinces in China. After the general analytic strategy used in the 2017 Global Burden of Disease study, we analyzed the incidence, mortality, prevalence and disability‐adjusted life‐years (DALYs) of melanoma, by age, sex and geography from 1990 to 2017. Levels in melanoma burden were assessed for 33 province‐level administrative units between 1990 and 2017. We used joinpoint regression analysis to estimate the slope of incidence and mortality trends. The age‐standardized incidence rate of melanoma was 0.9 per 100,000 in 2017, with a 110.3% rise compared to 1990. Although the age‐standardized DALYs rate (per 100,000) decreased from 9.1 in 1990 to 7.6 in 2017, it showed an upward trend from 2007 to 2017. The DALYs rate increased steadily with age for females while increased and peaked at 55–59 years for males. The incidence of melanoma was higher in the clustered eastern provinces than western provinces, while the DALYs showed a pattern in opposite direction. In China, there has been a substantial increase in the burden of melanoma over the last decade, representing an ongoing challenge in Chinese population. More targeted strategies should be developed for elderly population, especially for females, to reduce the melanoma burden throughout China, particularly the western provinces.

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Section: Discussionmentioning

confidence: 93%

Burden of melanoma in China, 1990–2017: Findings from the 2017 global burden of disease study

Wang

et al. 2019

Intl Journal of Cancer

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“…Skin cancers represent a major public health problem [1,2]. The incidence of cutaneous melanoma has increased over the years [3], and it can suppose a clinical and pathological challenge [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…There are some established risk factors for melanoma development, like family history [9,10], genetic and hereditary factors, as well as environmental factors [1,2,3]. Nowadays, nutritional factors have emerged as possible modifiable risk factors for cutaneous melanoma, since a growing number of studies have shown that a balanced diet, rich in fruits and vegetables, is associated with lower risks for several types of cancer, including cutaneous melanoma.…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, nutritional factors have emerged as possible modifiable risk factors for cutaneous melanoma, since a growing number of studies have shown that a balanced diet, rich in fruits and vegetables, is associated with lower risks for several types of cancer, including cutaneous melanoma. These nutrients have also been considered a possible alternative adjuvants to conventional therapies that are ineffective against this skin cancer type [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin A can be highlighted due to its role in normal and cancer conditions [11,12,13]. Vitamin A (retinol) is particularly important, since it cannot be synthesized by animals and, therefore, it must be supplied from the diet [1,14]. Vitamin A plays an critical role in cell differentiation [1,3], and has been demonstrated to inhibit several biological functions including tumor growth, angiogenesis and metastasis [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy?

Oliveira¹,

Costa²,

Faria³

et al. 2019

Medicina

Self Cite

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Background and objectives: The incidence of cutaneous melanoma has been increasing. Melanoma is an aggressive form of skin cancer irresponsive to radiation and chemotherapy, rendering this cancer a disease with poor prognosis: In order to surpass some of the limitations addressed to melanoma treatment, alternatives like vitamins have been investigated. In the present study, we address this relationship and investigate the possible role of vitamin A. Materials and Methods: We perform a co-culture assay using a macrophage cell model and RAW 264.7 from mouse, and also a murine melanoma cell line B16-F10. Macrophages were stimulated with both Escherichia coli lipopolysaccharides (LPS) as control, and also with LPS plus vitamin A. Results: Using B16-F10 and RAW 264.7 cell lines, we were able to demonstrate that low concentrations of vitamin A increase cytotoxic activity of macrophages, whereas higher concentrations have the opposite effect. Conclusion: These findings can constitute a new point of view related to immunostimulation by nutrients, which may be considered one major preventive strategy by enhancing the natural defense system of the body.

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Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study

Zengin

Sinan

et al. 2020

Industrial Crops and Products

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Melanoma and obesity: Should antioxidant vitamins be addressed?

Cited by 5 publications

References 92 publications

Burden of melanoma in China, 1990–2017: Findings from the 2017 global burden of disease study

Burden of melanoma in China, 1990–2017: Findings from the 2017 global burden of disease study

Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy?

Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study

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