Melanoma and use of sunscreens

Autier, Philippe; Doré, Jean‐François; Schifflers, E; Cesarini, J. P.; Bollaerts, A.; Koelmel, K. F.; Gefeller, Olaf; Liabeuf, A.; Lejeune, Ferdinand; Líénard, Danielle; Joarlette, M; Chemaly, P.; Kleeberg, U R

doi:10.1097/00008390-199509001-00092

Cited by 3 publications

(3 citation statements)

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“…However, UVA‐induced melanoma precursors did not progress to invasive melanomas (10). Use of sunscreens (which for a long time did not filter UVA at all or only very poorly, and even today provide less protection against UVA than against UVB) may increase melanoma risk (11). Individuals commonly use sunscreens to prolong the time they can spend in the sun without sunburning.…”

mentioning

confidence: 99%

Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)

Rünger

Kappes

2008

Photoderm Photoimm Photomed

142

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Long-wave ultraviolet (UV) A light is able to damage DNA, to cause mutations, and to induce skin cancer, but the exact mechanisms of UVA-induced mutation formation remain a matter of debate. While pyrimidine dimers are well established to mediate mutation formation with shortwave UVB, other types of DNA damage, such as oxidative base damage, have long been thought to be the premutagenic lesions for UVA mutagenesis. However, pyrimidine dimers can also be generated by UVA, and there are several lines of evidence that these are the most important premutagenic lesions not only for UVB- but also for UVA-induced mutation formation. C-->T transition mutations, which are generated by pyrimidine dimers, are called UV-signature mutations. They cannot be interpreted to be solely UVB-induced, as they are induced by UVA as well. Furthermore, there is no consistent evidence for a separate UVA-signature mutation that is only generated with UVA. We hypothesize that a weaker anti-mutagenic cellular response, but not a different type of DNA damage, may be responsible for a higher mutation rate per DNA photoproduct with UVA, as compared with UVB.

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mentioning

confidence: 99%

Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)

Rünger

Kappes

2008

Photoderm Photoimm Photomed

142

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“…In addition to having confounding factors, most epidemiologic studies, including sunscreen, sunburn, and tanning salon studies, are retrospective and are thereby subject to recall history and bias 6 . One‐quarter of the patients surveyed in one sunscreen study could not recall the details of which sunscreen they used or for what duration 74 . The definition of “intermittent” exposure varied widely.…”

Section: Sunscreen Studies: Weighing the Evidencementioning

confidence: 99%

Role of Sun Exposure in Melanoma

2006

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“…Μελέτες αναφέρουν τη χρήση αντιηλιακών και καπέλου ως στατιστικά σημαντικό παράγοντα κινδύνου για το μελάνωμα. Αυτό οφείλεται στο ότι αυτή η ομάδα πληθυσμού έχει φαινότυπο που σχετίζεται με αυξημένο κίνδυνο για μελάνωμα (Kriker, 1992;Autier et al, 1995).…”

Section: 12δ η χρήση αντιηλιακώνunclassified

Βιοχημική και ανοσολογική μελέτη της δράσης των αυξητικών παραγόντων στη βιοσύνθεση εκκρινόμενων Chondroitin και Dermatan sulfate πρωτεογλυκανών σε κυτταρικές σειρές μελανώματος και φυσιολογικών μελανοκυττάρων

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Melanoma is a frequent and therapy-resistant human disease. Malignant melanocytes modulate their microenvironment in order to penetrate the dermal/epidermal junction and eventually invade the dermis. The small leucine-rich proteoglycans (SLRPs) constitute important constituents of the dermis extracellular matrix (ECM), participating in both the structural and the functional organization of the skin. The role of a keratan sulphate SLRP lumican, has recently been investigated in the growth and metastasis of several cancers. In this study, the expression of lumican was studied in two human melanoma cell lines (WM9, M5) as well as in normal neonatal human melanocytes (HEMN) using real time PCR, western blotting with antibodies against the protein core and keratan sulfate, and treatments with specific enzymes. Both human metastatic melanoma cell lines were found to express lumican mRNA and effectively secrete lumican in a proteoglycan form, characterized to be substituted mostly with keratan sulfate chains. Lumican mRNA was not detected in normal melanocytes. This is the first time that the synthesis and secretion of lumican in human melanoma cell lines is reported. The role of this proteoglycan in the development and progression of malignant melanoma has to be further investigated.

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Melanoma and use of sunscreens

Cited by 3 publications

References 0 publications

Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)

Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)

Role of Sun Exposure in Melanoma

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