Melanoma cell migration to type IV collagen requires activation of NF-κB

Hodgson, Louis; Henderson, Andrew J.; Dong, Chuan

doi:10.1038/sj.onc.1206059

Cited by 42 publications

(34 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Type-IV collagen is a ECM protein and is highly common within the basement lamina and intima underlining the endothelium, excited chemotaxis of a number of human melanoma cell lines by engaging α2β1 integrin in vitro. Certain signal transduction incidents are driven by type-IV collagen through β1 integrins, suggesting a significant role for NF-κB in arranging chemotaxis of melanoma (9).…”

Section: Discussionmentioning

confidence: 99%

“…Increased laminin expression was also observed in melanoma cell lines and led to increased melanoma cell proliferation and metastatic potential (1-7). Similar to laminin, type-IV collagen is also an important structural component of the ECM and promotes melanoma cell adhesion, migration and invasion (6,7,(9)(10)(11). It has been proposed that type-IV collagen expression ensures the development of scaffolding required for angiogenesis in melanoma (6,7,(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

“…Similar to laminin, type-IV collagen is also an important structural component of the ECM and promotes melanoma cell adhesion, migration and invasion (6,7,(9)(10)(11). It has been proposed that type-IV collagen expression ensures the development of scaffolding required for angiogenesis in melanoma (6,7,(9)(10)(11). Type-IV collagen is a ECM protein and is highly common within the basement lamina and intima underlining the endothelium, excited chemotaxis of a number of human melanoma cell lines by engaging α2β1 integrin in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Increased expression of laminin and type-IV (1-7) collagen (6,7,(9)(10)(11) has also been demonstrated in melanoma cell lines with increased proliferation and metastatic potential (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…The proteins laminin and type-IV collagen are major structural constituents of the basement membrane, and serve as promoters of cell proliferation, differentiation, adhesion and migration via integrins and other cell surface receptors (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Increased expression of laminin and type-IV (1-7) collagen (6,7,(9)(10)(11) has also been demonstrated in melanoma cell lines with increased proliferation and metastatic potential (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

Taş

Bilgin

Karabulut

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

Taş

Bilgin

Karabulut

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening

Viegas,

Costa,

Dias

et al. 2024

Advanced Science

View full text Add to dashboard Cite

In vitro models are crucial in cancer research, but they must truthfully mimic in vivo tumors for clinical relevance. The development of unprecedent melanoma quadruple multicellular tumoroids (MCTs) is proposed comprising tumor cells, keratinocytes, fibroblasts, and monocytes that replicate tumor architecture, tumor microenvironment, and secretome behavior. These MCTs of 300 µm in diameter secreted keratin and collagen, showing complexity proportional to their cell combinations. Further, closely resembled in vivo tumors in terms of cells organization, growth, progression, and immune behavior. Drug screening using these MCTs demonstrated their potential as patient‐derived platforms for precision medicine. These findings highlight the true value of MCTs for studying melanoma biology and testing therapeutic interventions with greater precision and relevance to human disease.

show abstract

The role of exo‐miRNA in diagnosis and treatment of cancers, focusing on effective miRNAs in colorectal cancer

Kzar Al‐Shukri,

Abdul‐Jabbar Ali,

Al‐Akkam

et al. 2024

Cell Biology International

View full text Add to dashboard Cite

Small extracellular (EV) particles known as exosomes are released by a variety of cell types, including immune system cells, stem cells, and tumor cells. They are regarded as a subgroup of EVs and have a diameter that ranges from 30 to 150 nm. Proteins, lipids, nucleic acids (including RNA and DNA), and different bioactive compounds are among the wide range of biomolecules that make up the cargo of exosomes. Exosomes are crucial for intercellular communication because they let cells share information and signaling chemicals. They are involved in various physiological and pathological processes, including immune responses, tissue regeneration, cancer progression, and neurodegenerative diseases. In conclusion, it is essential to continue research into exosome‐based cancer medicines to advance understanding, improve treatment plans, create personalized tactics, ensure safety, and speed up clinical translation.

show abstract

Melanoma cell migration to type IV collagen requires activation of NF-κB

Cited by 42 publications

References 55 publications

Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening

The role of exo‐miRNA in diagnosis and treatment of cancers, focusing on effective miRNAs in colorectal cancer

Contact Info

Product

Resources

About