Melanoma-derived exosomes: Versatile extracellular vesicles for diagnosis, metastasis, immune modulation, and treatment of melanoma

Moosavian, Seyedeh Alia; Hashemi, Maryam; Etemad, Leila; Daneshmand, Sara; Salmasi, Zahra

doi:10.1016/j.intimp.2022.109320

Cited by 14 publications

(2 citation statements)

References 168 publications

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“…EVs are notable candidates for therapeutic applications because they have a natural ability to carry biomolecules and they share several features with parental cells. The EVs of selected cell types are thought to be applied as therapeutic agents in immune therapy, vaccination trials, regenerative medicine, and drug delivery (for review [ 143 , 144 , 145 , 146 , 147 , 148 , 149 ]. For example, exosomes secreted by stem cells have wide regenerative potential, which could be utilized in several areas such as wound healing [ 150 , 151 ], muscle regeneration [ 152 ], or neuron regrowth after spinal cord injury [ 153 ].…”

Section: Evs As Therapeutic Tools For Melanoma Treatmentmentioning

confidence: 99%

Extracellular Vesicles-Based Cell-Cell Communication in Melanoma: New Perspectives in Diagnostics and Therapy

Kluszczyńska

Czyż

2023

IJMS

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Extracellular vesicles (EVs) are a heterogeneous group of cell-secreted particles that carry cargo of functional biomolecules crucial for cell-to-cell communication with both physiological and pathophysiological consequences. In this review, we focus on evidence demonstrating that the EV-mediated crosstalk between melanoma cells within tumor, between melanoma cells and immune and stromal cells, promotes immune evasion and influences all steps of melanoma development from local progression, pre-metastatic niche formation, to metastatic colonization of distant organs. We also discuss the role of EVs in the development of resistance to immunotherapy and therapy with BRAFV600/MEK inhibitors, and shortly summarize the recent advances on the potential applications of EVs in melanoma diagnostics and therapy.

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Section: Evs As Therapeutic Tools For Melanoma Treatmentmentioning

confidence: 99%

Extracellular Vesicles-Based Cell-Cell Communication in Melanoma: New Perspectives in Diagnostics and Therapy

Kluszczyńska

Czyż

2023

IJMS

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“…Recently, increasing evidence have shown the close relationship between EVs and TME (Figure 1), which is responsible for the tumor progression, including melanoma (15)(16)(17). Therefore, in this review, we aimed to summarize the role of EVs in melanoma by targeting TME, and discuss the potential of EVs to be applied as an alternative option for the clinical treatment of melanoma.…”

Section: Introductionmentioning

confidence: 99%

The extracellular vesicles targeting tumor microenvironment: a promising therapeutic strategy for melanoma

Liu

2023

Front. Immunol.

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Extracellular vesicles (EVs) are small particles secreted by numerous cell types and circulate in almost all body fluids, acting as crucial messengers for cell-to-cell communication. EVs involves multiple physiological and pathological processes, including tumor progression, via their multiple cargoes. Therefore, EVs have become attractive candidates for the treatment of tumor, including melanoma. Notably, due to the crucial role of the tumor microenvironment (TME) in promoting tumor malignant phenotype, and the close intercellular communication in TME, EVs-based therapy by targeting TME has become a cutting-edge and prospective strategy for inhibiting melanoma progression and strengthening the anti-tumor immunity. In this review, we aimed to summarize and discuss the role of therapeutic EVs, which target the components of TME in melanoma, thereby providing insights into these promising clinical strategies for the treatment of melanoma patients.

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Discovery of Structural Diversity Guided N‐S Heterocyclic Derivatives Based on Natural Benzothiazole Alkaloids as Potential Cytotoxic Agents

Guo,

Wan,

Liu

et al. 2024

Journal of Heterocyclic Chem

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Benzothiazole alkaloids are a class of rare heterocyclic alkaloids with unique structures and exhibit a wide range of biological activities. So, the aim of this work is to investigate structural diversity‐guided N‐S heterocyclic derivatives based on natural benzothiazole alkaloids as potential cytotoxic agents. Three series of novel benzothiazole derivatives, including 22 compounds, were designed and synthesized using pharmacophore hybridization, and their in vitro cytotoxic activities against Huh‐7 and A875 were fully evaluated. The results indicated that some of these benzothiazole derivatives had significantly good cytotoxic activities against two tested cell lines compared with the positive control 5‐fluorouracil, and other compounds 3f–3i displayed good selectivity between A875 and Huh‐7 cell lines, which might be used as promising lead molecule for discovery of novel benzothiazole‐type cytotoxic agents.

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Melanoma-derived exosomes: Versatile extracellular vesicles for diagnosis, metastasis, immune modulation, and treatment of melanoma

Cited by 14 publications

References 168 publications

Extracellular Vesicles-Based Cell-Cell Communication in Melanoma: New Perspectives in Diagnostics and Therapy

Extracellular Vesicles-Based Cell-Cell Communication in Melanoma: New Perspectives in Diagnostics and Therapy

The extracellular vesicles targeting tumor microenvironment: a promising therapeutic strategy for melanoma

Discovery of Structural Diversity Guided N‐S Heterocyclic Derivatives Based on Natural Benzothiazole Alkaloids as Potential Cytotoxic Agents

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