Melanoma en vejiga, reporte de un caso y revisión de la literatura

Casimiro-Guzmán, L.; Hernández-Román, L.U.; Cruz-Contreras, L.H.; Chávez-Martínez, S.

doi:10.1016/j.uromx.2015.08.001

Cited by 4 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the time of cystoscopy, a single lesion with an implantation base or several lesions such as small, pigmented, and elevated nodules covering the urothelium, as found in the patient, may be evidenced [10,13] . Histopathologically, atypical melanocytic cells similar to the primary tumor are evident.…”

Section: Discussionmentioning

confidence: 97%

“…Regarding symptomatology, it is known that most patients are asymptomatic and only 15% present hematuria, its most frequent form of presentation [5,9] . For this reason, for patients with a previous history of melanoma who develop voiding syndrome (dysuria, difficulty urinating, urinary urgency, pollakiuria or nocturia) and hematuria, it is recommended that endoscopic studies be performed to exclude metastatic involvement at the bladder level [8][9][10][11] . Autopsy studies have shown that up to 18% of patients with metastatic disease have unknown bladder involvement [12] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case Report of Metastatic Melanoma to the Bladder

Ortiz-Zableh,

Sandoval-Ojeda,

Patiño-Covelli

et al. 2023

View full text Add to dashboard Cite

Objective: The objective of this report is to present the case of metastatic melanoma to the bladder, a rare and underdiagnosed condition due to its often asymptomatic characteristic. Case presentation: The case was a 62-year-old female patient, with a history of melanoma at the level of the first toe, with surgical and pharmacological management. The reason for consultation was hematuria. Cystoscopy revealed a single solid, erythematous lesion with necrosis and easy bleeding, and transurethral resection (TUR) was indicated. The pathology found metastatic ulcerated melanoma. Second-line treatment (pembrolizumab) was started and presented progression to the upper limbs and relapse at the bladder level. The patient died a year later. Discussion: Melanoma metastases to the genitourinary tract are common, but isolated bladder metastases are rare. Treatment is usually TUR of the lesion, cystectomy, chemotherapy, and radiation therapy. TUR is curative for lesions restricted to the epithelium, although radical cystectomy is usually the therapy of choice in patients with a localized tumor. Pembrolizumab has been shown to increase survival. The prognosis depends on the size and depth of the invasion. Conclusion: Metastatic cancer to the bladder is rare and underdiagnosed, it may be present in patients with melanoma, nonspecific urinary irritative symptoms, and hematuria. It tends to have a poor prognosis, and requires surgical treatment associated with systemic management.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

A Case Report of Metastatic Melanoma to the Bladder

Ortiz-Zableh,

Sandoval-Ojeda,

Patiño-Covelli

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Respecto a la sintomatología, se conoce que la mayoría de los pacientes son asintomáticos y sólo 15% presentan hematuria, su forma de presentación más frecuente (5,9). Por este motivo, a todo paciente con historia previa de melanoma, que desarrolla síndrome miccional (dado por disuria, dificultad para la micción, sensación de tenesmo vesical, polaquiuria o nicturia) y hematuria, se recomienda realizarle estudios endoscópicos para excluir el compromiso metastásico a nivel vesical (8)(9)(10)(11). Estudios en autopsias han demostrado que hasta 18% de los pacientes con enfermedad metastásica tienen compromiso vesical no conocido (12).…”

Section: Discussionunclassified

“…En el momento en que se realice la cistoscopia se puede evidenciar una lesión única, con base de implantación o varias lesiones como pequeños nódulos, pigmentados y elevados que cubren el urotelio, como la encontrada en la paciente (10,13). A nivel histopatológico, se evidencian células melanocíticas atípicas similares al tumor primario.…”

Section: Discussionunclassified

Melanoma metastásico a vejiga

Zableh

Sandoval

Patiño-Covelli

et al. 2022

MedUNAB

View full text Add to dashboard Cite

Introducción. El compromiso tumoral metastásico del melanoma al tracto genitourinario es frecuente, pero, la metástasis a vejiga es rara, constituye menos del 2% de los casos. Sin embargo, en autopsias realizadas a pacientes con melanoma se ha encontrado metástasis en la vejiga en entre un 18% y un 37% de los casos, lo que la convierte en la segunda en incidencia posterior al adenocarcinoma gástrico. La media de supervivencia suele ser entre 6 - 7.5 meses. El objetivo de este trabajo es presentar el caso de un melanoma metastásico a vejiga, entidad poco frecuente y poco diagnosticada por ser la mayoría de las veces asintomática. Presentación del caso. Paciente femenina de 62 años, con antecedente de melanoma al nivel del primer artejo del pie, con manejo quirúrgico y farmacológico. Consultó por hematuria. La cistoscopia evidenció una lesión única sólida, eritematosa, con necrosis y fácil sangrado y se indicó realizar resección transuretral (RTU). La patología demostró compromiso por melanoma ulcerado metastásico. Se inició manejo de segunda línea (Pembrolizumab) y presentó progresión a miembros superiores y recaída a nivel vesical. La paciente falleció un año después. Discusión. Las metástasis de melanoma al tracto genitourinario son frecuentes, pero las metástasis vesicales aisladas son raras. El tratamiento suele ser RTU de la lesión, cistectomía, quimioterapia y radioterapia. La RTU es curativa para las lesiones restringidas al epitelio, aunque la cistectomía radical suele ser la terapia de elección ante un paciente con un tumor localizado. El Pembrolizumab ha demostrado aumentar la supervivencia. El pronóstico depende del tamaño y profundidad de la invasión. Conclusiones. El compromiso vesical metastásico es poco frecuente y diagnosticado, puede estar presente en pacientes con melanoma, síntomas irritativos urinarios no específicos y hematuria. Suele ser de mal pronóstico, y requiere de manejo quirúrgico asociado a manejo sistémico.

show abstract

“…[2] The usual clinical manifestations include gross hematuria and urinary symptoms such as pollakiuria, dysuria, and acute urinary retention but do not allow suspecting the diagnosis. [1,5,6] The diagnostic tests used are renovesicoprostatic ultrasound, urethrocystoscopy, and urinary cytology. For the definitive diagnosis, transurethral resection of the tumor tissue is mandatory and the anatomopathological study can objectify the presence of different histological patterns such as elongated epithelioid cells, small diffuse cells, polygonal forms and mixed variant, [5] with necrosis, nuclear pleomorphism with numerous mitosis, and intracellular melanin deposits.…”

Section: Discussionmentioning

confidence: 99%

Acute Obstructive Renal Failure Secondary to Primary Bladder Melanoma

Sevilla¹,

Lanza²,

Alcaraz³

et al. 2019

Clinic Res Urol

View full text Add to dashboard Cite

BACKGROUNDB ladder melanoma appears more frequently as metastasis of a cutaneous melanoma being present in up to 18% of patients who died due to metastatic melanoma. [1] It is also described as a primary tumor of the bladder in <0.2% of all melanomas. [2] About 70% of published cases of primary bladder melanoma infiltrate the muscularis propria. [1] Radical cystectomy plus urinary derivation is the treatment that can improve survival. [3] In most of the 26 cases published, to date, the prognosis is poor despite surgical treatment, chemotherapy, and immunotherapy. [1,4]

show abstract

Melanoma en vejiga, reporte de un caso y revisión de la literatura

Cited by 4 publications

References 8 publications

A Case Report of Metastatic Melanoma to the Bladder

A Case Report of Metastatic Melanoma to the Bladder

Melanoma metastásico a vejiga

Acute Obstructive Renal Failure Secondary to Primary Bladder Melanoma

Contact Info

Product

Resources

About