Melanoma epidemiology of Austria reveals gender-related differences

Duschek, Nikolaus; Skvara, Hans; Kittler, Harald; Delir, Golnaz; Fink, Astrid; Pinkowicz, Anja; Waldhör, Thomas

doi:10.1684/ejd.2013.2192

Cited by 14 publications

(15 citation statements)

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“…The analysis also suggests that there exists interaction between gender and race – it is observed that females have higher incidence among HWs for MIS and SSM, but for other cases, the trend is reversed. Previous studies have noted the interaction between gender and age for incidence [21]. However the interaction observed in this study has been less acknowledged.…”

Section: Discussioncontrasting

confidence: 59%

Racial differences in six major subtypes of melanoma: descriptive epidemiology

2016

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BackgroundMelanoma accounts for the majority of skin cancer deaths. It has over thirty different subtypes. Different races have been observed to differ in multiple aspects of melanoma.MethodsSEER (Surveillance, Epidemiology, and End Results) data on six major subtypes, namely melanoma in situ (MIS), superficial spreading melanoma (SSM), nodular melanoma (NM), lentigo maligna melanoma (LMM), acral lentiginous melanoma malignant (ALM), and malignant melanoma NOS (NOS), were analyzed. The racial groups studied included NHW (non-Hispanic white), HW (Hispanic white), Black, and Asian/PI (Pacific Islanders). Univariate and multivariate analysis was conducted to quantify racial differences in patients’ characteristics, incidence, treatment, and survival.ResultsSignificant racial differences are observed in patients’ characteristics. For all subtypes except for ALM, NHWs have the highest incidence rates, followed by HWs, while Blacks have the lowest. For ALM, HWs have the highest rate, followed by NHWs. In stratified analysis, interaction between gender and race is observed. For the first five subtypes and localized and regional NOS, the dominating majority of patients had surgery, while for distant NOS, the distribution of treatment is more scattered. Significant racial differences are observed for distant ALM and NOS. For MIS, SSM, NM, LMM, and ALM, there is no significant racial difference in survival. For NOS, significant racial differences in survival are observed for the localized and regional stages, with NHWs having the best and Blacks having the worst five-year survival rates.ConclusionsRacial differences exist for the six major melanoma subtypes in the U.S. More data collection and analysis are needed to fully describe and interpret the differences across racial groups and across subtypes.

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Section: Discussioncontrasting

confidence: 59%

Racial differences in six major subtypes of melanoma: descriptive epidemiology

2016

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“…The current 8th American Joint Committee on Cancer (AJCC) staging system includes Breslow thickness, ulceration, nodal and visceral metastases as predictors for survival in melanoma patients . The prognostic value of gender in localized melanoma has been studied extensively, with several large studies (>10 000 patients each) showing a survival advantage for females …”

Section: Introductionmentioning

confidence: 99%

“…4 The prognostic value of gender in localized melanoma has been studied extensively, with several large studies (>10 000 patients each) showing a survival advantage for females. [5][6][7][8][9][10][11][12][13][14] The cause as to why female patients have better survival remains controversial. Some have argued that biological differences between melanoma in men and women are due to hormonal influences of oestrogen and androgen.…”

Section: Introductionmentioning

confidence: 99%

Sex matters: men with melanoma have a worse prognosis than women

Sharouni

Witkamp

Sigurdsson

et al. 2019

Acad Dermatol Venereol

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Background In Europe, one of the highest melanoma incidences is found in the Netherlands. Like in several other European countries, females are more prone to develop melanoma as compared to males, although survival is worse for men. Objective To identify clinicopathological gender‐related differences that may lead to gender‐specific preventive measures. Methods Data from the Dutch Nationwide Network and Registry of Histopathology and Cytopathology (PALGA) were retrieved from patients with primary, cutaneous melanoma in the Netherlands between 2000 and 2014. Patients initially presenting as stage I, II and III without clinically detectable nodal disease were included. Follow‐up data were retrieved from the Netherlands Cancer Registry. Gender‐related differences were assessed, and to compare relative survival between males and females, multivariable relative excess risks (RER) were calculated. Results A total of 54.645 patients were included (43.7% men). In 2000, 41.7% of the cohort was male, as compared to 47.3% in 2014 (P < 0.001). Likewise, in 2000, 51.5% of the deceased cohort was male compared to 60.1% in 2014 (P < 0.001). Men had significantly thicker melanomas at the time of diagnosis [median Breslow thickness 1.00 mm (interquartile range (IQR): 0.60–2.00) vs. 0.82 mm (IQR: 0.50–1.50) for females] and were significantly older at the time of diagnosis, more often had ulcerated melanomas and melanomas localized on the trunk or head and neck. Over time, survival for females improved while that of men decreased (P < 0.001). RER for dying was 1.37 (95% CI: 1.31–1.45) for men in multivariable analysis. Conclusion There are evident clinicopathological differences between male and female melanoma patients. After multivariable correction for all these differences, relative survival remains worse for men. Clinicians as well as persons at risk for melanoma should be aware of these differences, as awareness and prevention might lead to a lower incidence and mortality of melanoma. This indicates the need of prevention campaigns integrating and targeting specific risk profiles.

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“…Numerous studies investigated the incidence and mortality rates of CM in Caucasian populations (Barbaric et al, 2016; Wallingford et al, 2013; Bristow et al, 2013; Duschek et al, 2013; Sneyd & Cox, 2013), however, only a small number of studies exist focusing on the incidence and mortality rates of CM in East Asian populations. Research investigating average annual age-standardized incidence rate of CM in Japan was 0.25 per 100,000 for men, and 0.20 per 100,000 for women between 1964 and 1995 (Tanaka et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Trends in mortality rates of cutaneous melanoma in East Asian populations

Chen

Jin

2016

PeerJ

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The incidence of cutaneous melanoma (CM) has rapidly increased over the past four decades. CM is often overlooked in East Asian populations due to its low incidence, despite East Asia making up 22% of the world’s population. Since the 1990s, Caucasian populations have seen a plateau in CM mortality rates; however, there is little data investigating the mortality rates of CM in East Asian populations. In this study, the World Health Organization Mortality Database with the joinpoint regression method, and a generalized additive model were used to investigate trends in age standardized mortality rates (ASMRs) of CM in four East Asia regions (Japan, Republic of Korea (Korea), China: Hong Kong (Hong Kong), and Singapore) over the past six decades. In addition, mortality rate ratios by different variables (i.e., sex, age group, and region) were analyzed. Our results showed ASMRs of CM in East Asia significantly increased non-linearly over the past six decades. The joinpoint regression method indicated women had greater annual percentage changes than men in Japan, Korea, and Hong Kong. Men had significantly greater mortality rate ratio (1.51, 95% CI [1.48–1.54]) than women. Mortality rate ratios in 30−59 and 60+ years were significant greater than in the 0−29 years. Compared to Hong Kong, mortality rate ratio was 0.72 (95% CI [0.70–0.74]) times, 0.73 (95% CI [0.70–0.75]) times, and 1.02 (95% CI [1.00–1.05]) times greater in Japan, Korea, and Singapore, respectively. Although there is limited research investigating CM mortality rates in East Asia, results from the present study indicate that there is a significant growth in the ASMRs of CM in East Asian populations, highlighting a need to raise awareness of CM in the general population.

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Melanoma epidemiology of Austria reveals gender-related differences

Cited by 14 publications

References 0 publications

Racial differences in six major subtypes of melanoma: descriptive epidemiology

Racial differences in six major subtypes of melanoma: descriptive epidemiology

Sex matters: men with melanoma have a worse prognosis than women

Trends in mortality rates of cutaneous melanoma in East Asian populations

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