Melanoma in the ampulla of Vater

Bendic, Antonia; Durdov, Merica Glavina; Stipić, Radoslav; Karaman, Ivana

doi:10.1016/s1499-3872(13)60016-8

Cited by 12 publications

(14 citation statements)

References 11 publications

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“…Painless obstructive jaundice is the usual finding, and prognosis is dismal unless curative resection can be achieved. Five cases of ampullary metastasis causing obstructive jaundice have also been reported, all requiring endoscopic drainage or surgery[ 177 - 181 ].…”

Section: Primary Malignanciesmentioning

confidence: 99%

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

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Malignant biliary obstruction generally results from primary malignancies of the pancreatic head, bile duct, gallbladder, liver, and ampulla of Vater. Metastatic lesions from other primaries to these organs or nearby lymph nodes are rarer causes of biliary obstruction. The most common primaries include renal cancer, lung cancer, gastric cancer, colorectal cancer, breast cancer, lymphoma, and melanoma. They may be difficult to differentiate from primary hepato-pancreato-biliary cancer based on imaging studies, or even on biopsy. There is also no consensus on the optimal method of treatment, including the feasibility and effectiveness of endoscopic intervention or surgery. A thorough review of the literature on pancreato-biliary metastases and malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer is presented. The diagnostic modality and clinical characteristics may differ significantly depending on the type of primary cancer. Different primaries also cause malignant biliary obstruction in different ways, including direct invasion, pancreatic or biliary metastasis, hilar lymph node metastasis, liver metastasis, and peritoneal carcinomatosis. Metastasectomy may hold promise for some types of pancreato-biliary metastases. This review aims to elucidate the current knowledge in this area, which has received sparse attention in the past. The aging population, advances in diagnostic imaging, and improved treatment options may lead to an increase in these rare occurrences going forward.

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Section: Primary Malignanciesmentioning

confidence: 99%

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

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“…The clinical presentation is usually non-specific, including vague abdominal pain, unexplained weight loss, iron-deficiency anaemia, change in bowel habits and GI bleeding, or even painless jaundice when in the duodenum [37], though a large portion will be asymptomatic. Rarely, patients can present with an acute abdomen due to intestinal obstruction, intussusception, perforation or fistula [27,[38][39][40].…”

Section: Duodenum and Small Bowelmentioning

confidence: 99%

The different faces of metastatic melanoma in the gastrointestinal tract

et al. 2022

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Melanoma is the most aggressive form of skin cancer, with tendency to spread to any organ of the human body, including the gastrointestinal tract (GIT). The diagnosis of metastases to the GIT can be difficult, as they may be clinically silent for somewhile and may occur years after the initial melanoma diagnosis. CT imaging remains the standard modality for staging and surveillance of melanoma patients, and in most cases, it will be the first imaging modality to identify GIT lesions. However, interpretation of CT studies in patients with melanoma can be challenging as lesions may be subtle and random in distribution, as well as sometimes mimicking other conditions. Even so, early diagnosis of GIT metastases is critical to avoid emergency hospitalisations, whilst surgical intervention can be curative in some cases. In this review, we illustrate the various imaging presentations of melanoma metastases within the GIT, discuss the clinical aspects and offer advice on investigation and management. We offer tips intended to aid radiologists in their diagnostic skills and interpretation of melanoma imaging scans.

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“…Barium examination can improve intestinal imaging but is not appropriate for extraintestinal findings (10,29). CT allows for better visualization of the duodenum and can define extraluminal and metastatic disease, although the reported sensitivity of CT for detection of intestinal melanoma is only 60-70% (30)(31)(32). Sensitivity and specificity are higher with 18-fluorodeoxyglucose wholebody positron emission tomography imaging (FDG-PET), which can offer a dual advantage by excluding other primary tumors and by staging the disease (21,33).…”

Section: Diagnosismentioning

confidence: 99%

Primary Duodenal Melanoma: Challenges in Diagnosis and Management of a Rare Entity

Dimopoulou

et al. 2022

Acta Med. (Hradec Kralove, Czech Repub.)

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Primary melanoma of the duodenum is an extremely rare, aggressive and life-threatening malignant neoplasm. Published data regarding the effectiveness of current treatment strategies is limited, and our knowledge relies mostly on sporadic case reports. The diagnosis of primary duodenal melanoma is challenging and is based on the patient’s medical history and findings from physical examination and radiological and endoscopic imaging as well as proper and careful pathological examinations of the tumor. Despite the many advances in cancer treatment, the prognosis for patients with this type of melanoma remains extremely poor. Delayed diagnosis at advanced disease stage, the general aggressive behavior of this neoplasm, the technical difficulty in achieving complete surgical resection, along with the rich vascular and lymphatic drainage of the intestinal mucosa, all have a negative impact on patients’ outcome. In the present review, we aimed to collect and summarize the currently available data in the literature regarding the pathogenesis, clinical features, diagnosis, management and long-term outcomes of this rare, malignant tumor, in order to expand knowledge of its biological behavior and investigate optimal therapeutic options for these patients. Additionally, we present our experience of a case involving a 73-year-old female with primary duodenal melanoma, who was successfully treated with complete surgical resection.

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Melanoma in the ampulla of Vater

Cited by 12 publications

References 11 publications

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

The different faces of metastatic melanoma in the gastrointestinal tract

Primary Duodenal Melanoma: Challenges in Diagnosis and Management of a Rare Entity

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