Melanoma Incidence Increases in the Elderly of Catalonia But Not in the Younger Population: Effect of Prevention or Consequence of Immigration?

Puig, Susana; Marcoval, Joaquim; Paradelo, Cristina; Azón-Masoliver, Antoni; Bartralot, R.; S, Bel; Bigatà, X.; Boada, Aram; Campoy, Antoni; Carrera, Cristina; Curcó, N.; Dalmau, Joan; Ferrándiz, Carlos; Ferreres,; Formigón, M; Gallardo, F. Perez; González, Alberto Durán; Just, Miquel; Llistosella, E; Martí, Rosa M.; Me, Nogues; Pedragosa, R; Ja, Pujol; Roldán–Marín, Rodrigo; Sàbat, Mireia; Salleras, M.; Ja, Smandia; Zaballos, Pedro; Plana, Estel; Malvehy, Josep

doi:10.2340/00015555-1997

Cited by 29 publications

(30 citation statements)

References 18 publications

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“…Although it is well known that Catalan and Spanish live expectancy is growing up and that there is progressively a higher proportion of population within the group at risk for having LM/LMM, in our study the mean age of LM/LMM patients remained stable during all the period. In contrast, we observed an increase in the mean age at diagnosis of the whole melanoma series . These findings point out that aging of the population is not necessarily the only explanation for the LM/LMM increasing rate observed in our study.…”

Section: Discussioncontrasting

confidence: 84%

“…As we have recently reported, SSM is the most common melanoma subtype (59.5%) in Catalonia, north‐eastern part of Spain. The aim of the present study was to describe the epidemiological trend of LM/LMM and its relation to the aging of the population studied in the same sample and period, 2000–2007.…”

Section: Introductionmentioning

confidence: 57%

“…Concerning LM/LMM alone, the mean age at diagnosis was 73 years (26–94). Mean age at diagnosis increased during the period for the whole melanoma group ( P < 0.001) but remained stable for LM/LMM (Table ). Regarding gender, 225 cases (54%) were females, whereas 190 (46%) were males.…”

Section: Resultsmentioning

confidence: 97%

“…During the 8‐year study period (2000–2007), a total of 4,999 melanoma patients were reported . Of them all, 282 (5.7%) were LM and 136 (2.7%) LMM which account as a whole for 8.4% of melanoma cases with a mean Breslow thickness of 1.29 mm for the invasive ones.…”

Section: Resultsmentioning

confidence: 99%

“…Data from a hospital‐based registry of melanoma cases diagnosed from 2000 to 2007 in Catalonia, 7 million inhabitants, were reported from 23 different hospitals, most public hospitals (with the exception of Hospital General de Catalunya). As we previously described, data were collected from the melanoma‐unit's databases when available (Hospital Clinic de Barcelona, Hospital de Bellvitge and Hospital Germans Trias i Pujol, which reported 59% of cases). For the remaining hospitals, data were retrospectively collected for the first 5‐year period and then prospectively.…”

Section: Methodsmentioning

confidence: 99%

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Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

et al. 2018

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Background Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM). Methods In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded. Results Although for the global period LM/LMM represented only 8.4% of cases, an increasing trend in this percentage was observed throughout the study period (from 6.9% [27 cases] in 2000 to 13.1% [94 cases] in 2007). Also, an increasing incidence of LM/LMM was observed, especially in chronically sun‐exposed areas (85.5% involving the head and neck region). During the 8 years of the registry, the mean Breslow thickness of LMM remained stable. However, the increase in the number of LM (in situ) cases was significantly higher than the increase of the invasive ones. Conclusions An important observation from this data is that aging of population and current sun exposure patterns could keep increasing the incidence of LM/LMM, which may become an important public healthcare problem, over the other histological subtypes. In order to establish primary or secondary preventive measures to the LM/LMM risk‐population, it is imperative to highlight the importance of chronic sun damage as a melanoma risk factor, and not only sunburn, most commonly addressed in melanoma prevention campaigns.

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Section: Discussioncontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

et al. 2018

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Melanoma Incidence and Mortality Trends Among Patients Aged 59 Years or Younger in Sweden

Helgadottir,

Mikiver,

Schultz

et al. 2024

JAMA Dermatol

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ImportanceOver the past decades, many global regions have experienced a steady increase in the incidence of cutaneous melanoma. However, more recently, a downward trend has been observed in the younger age groups in Australia and the US. Yet, in Europe, none of the countries have reported any significant decline in melanoma incidence for any age group.ObjectiveTo assess melanoma incidence and mortality trends in Sweden, with a focus on individuals younger than the average age of melanoma onset.Design, Setting, and ParticipantsThis cohort study used data on the national population from the Swedish Melanoma Registry and the Swedish Cancer Registry, which cover more than 99% of all primary invasive cutaneous melanomas diagnosed in the country. All patients diagnosed from 1990 to 2022 were included.Main Outcomes and MeasuresIncidence and mortality rates per 100 000 inhabitants were calculated for each year and shown as average annual rates for every 5-year period from 1990 to 2022. Joinpoint regression models were used to evaluate statistical significance of temporal trends and points of change.ResultsThere were 34 800 primary invasive cutaneous melanomas (19 582 [56.3%] in females and 15 218 [43.7%] in males) reported in 33 324 individuals younger than 60 years (median [IQR] age, 48 [36-58] years) from 1990 to 2022. A consistent rise in melanoma incidence was observed among those 50 to 59 years old. The age groups from 20 to 29 years, 30 to 39 years, and 40 to 49 years showed an incidence peak in 2013 to 2015 followed by stable or significantly declining rates until 2022. In patients younger than 20 years, melanoma incidence remained low with no significant trends. There was also a significant decline in melanoma mortality among 30- to 59-year-old individuals, but not in those 60 years and older.Conclusions and RelevanceThe findings of this cohort study showed a significant recent downward trend in both melanoma incidence and melanoma mortality in the age group 30 to 49 years in Sweden. The reasons for these declines are unclear but may include UV protection, public health campaigns, changing population demographics, and the introduction of effective melanoma treatment. None of these possibilities were evaluated; further study is needed.

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High nevus counts confer a favorable prognosis in melanoma patients

Ribero

Davies

Requena

et al. 2015

Intl Journal of Cancer

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A high number of naevi is the most significant phenotypic risk factor for melanoma and is in part genetically determined. The number of naevi decreases from middle age onwards but this senescence can be delayed in melanoma patients. We investigated the effects of naevus number count on sentinel node status and melanoma survival in a large cohort of melanoma cases. Out of 2184 melanoma cases, 684 (31.3%) had a high naevus count (>50). High naevus counts were associated with favourable prognostic factors such as lower Breslow thickness, less ulceration and lower mitotic rate, despite adjustment for age. Naevus count was not predictive of sentinel node status. The crude 5- and 10-year melanoma specific survival rate was higher in melanomas cases with a high naevus count compared to those with a low naevus count (91.2% vs 86.4% and 87.2% vs 79%, respectively). The difference in survival remained significant after adjusting for all known melanoma prognostic factors (HR= 0.43, CI 0.21-0.89). The favourable prognostic value of a high naevus count was also seen within the positive sentinel node subgroup of patients (HR=0.22, CI 0.08-0.60). High naevus count is associated with a better melanoma survival, even in the subgroup of patients with positive sentinel lymph node. This suggests a different biological behaviour of melanoma tumours in patients with an excess of naevi.

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Melanoma Incidence Increases in the Elderly of Catalonia But Not in the Younger Population: Effect of Prevention or Consequence of Immigration?

Cited by 29 publications

References 18 publications

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

Melanoma Incidence and Mortality Trends Among Patients Aged 59 Years or Younger in Sweden

High nevus counts confer a favorable prognosis in melanoma patients

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