Melanoma

Coit, Daniel G.; Andtbacka, Robert H.I.; Bichakjian, Christopher K.; Dilawari, Raza A.; DiMaio, Dominick J.; Guild, Valerie; Halpern, Allan C.; Hodi, F. Stephen; Kashani‐Sabet, Mohammed; Lange, Julie R.; Lind, Anne C.; Martin, Lainie P.; Martini, Mary C.; Pruitt, Scott K.; Ross, Merrick I.; Sener, Stephen F.; Swetter, Susan M.; Tanabe, Kenneth K.; Thompson, John A.; Trisal, Vijay; Urist, Marshall M.; Weber, Jeffrey S.; Wong, Michael K.

doi:10.6004/jnccn.2009.0020

Cited by 137 publications

(83 citation statements)

References 89 publications

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“…Excisional biopsy was performed with total thickness excision and a narrow margin, as described in the American Association of Dermatology Guidelines and the National Cancer Comprehensive Network Clinical Practice Guidelines [14,15]. Date of diagnosis was defined as the date of excisional biopsy.…”

Section: Melanoma Diagnosismentioning

confidence: 99%

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients – An EORTC Melanoma Group study

Ophuis

Verhoef

Rutkowski

et al. 2016

European Journal of Surgical Oncology (EJSO)

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SynopsisThis study examines >1000 sentinel node (SN) positive melanoma patients. Time interval between primary excision and SN biopsy (SNB) is no prognostic factor for disease free and melanoma specific survival. Guidelines advocating SNB <6 weeks should be reconsidered. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 3 AbstractBackground: Worldwide, sentinel node biopsy (SNB) is the recommended staging procedure for

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Section: Melanoma Diagnosismentioning

confidence: 99%

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients – An EORTC Melanoma Group study

Ophuis

Verhoef

Rutkowski

et al. 2016

European Journal of Surgical Oncology (EJSO)

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“…1 Whereas patients without nodal involvement generally have excellent outcomes, those with nodal involvement more commonly experience recurrence after resection and diminished survival. Previous investigations suggest that melanoma-draining lymph nodes demonstrate immunologic alterations and are likely immunosuppressed.…”

mentioning

confidence: 99%

Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis

et al. 2011

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In order to characterize the degree of immunosuppression in regional immunity in patients with melanoma, we used immunohistochemistry to analyze markers of T-cell subtype and polarity, costimulation, dendritic cell maturation, monocytes, lymphatic vasculature, and angiogenesis. Specifically, we analyzed expression of CD4, CD8, CD14, CD40, CD86, CD123, HLA-DR, IL-10, LYVE, VEGFR3, and VEGF-C in lymph nodes. We compared sentinel lymph nodes with and without metastasis from patients with melanoma with both infection inflamed (reactive) and dormant human lymph nodes. There were no differences demonstrated between sentinel lymph nodes with or without metastasis from patients with melanoma in any of the markers that were tested. Both groups of sentinel lymph nodes had fewer CD8 þ T cells than either set of control nodes. Whereas the infection inflamed lymph nodes demonstrated Th2 polarity, the dormant lymph nodes demonstrated Th1 polarity. In conclusion, changes in regional immunity appeared to precede metastasis in melanoma. Whether there was tumor present in sentinel lymph nodes or not, these nodes demonstrated a marked decrease in cytotoxic T cells compared with both sets of controls. Furthermore, the control lymph nodes used for comparison can significantly impact interpretation, as the dormant and reactive lymph nodes markedly varied in their immune profiles. These immunologic changes may explain the successful metastasis of melanoma in the midst of the immune environment of the sentinel lymph node, and lend insights into the mechanisms of lymphatic metastases in other solid malignancies. Modern Pathology (2011) 24, 487-494; doi:10.1038/modpathol.2010.227; published online 10 December 2010Keywords: angiogenesis; cytotoxic T cells; lymph nodes; melanoma; regional immunity Lymph node metastasis is one of the most important prognostic factors in melanoma.1 Whereas patients without nodal involvement generally have excellent outcomes, those with nodal involvement more commonly experience recurrence after resection and diminished survival. Previous investigations suggest that melanoma-draining lymph nodes demonstrate immunologic alterations and are likely immunosuppressed.2 Sentinel lymph nodes are the first lymph nodes to drain a tumor bed, and represent the first expected site of metastasis of melanoma.3,4 Sentinel lymph nodes are a site of contact between tumor-associated antigens and the adaptive immune system and represent a regional unit of metastasis and immune response. Accordingly, sentinel lymph nodes are an ideal setting for the investigations of the early immunologic (endocrine and paracrine) events that lead up to melanoma progression from a primary tumor to metastatic cancer. In the past year, we have described that patients with metastatic melanoma exist in a state of systemic chronic inflammation driven by tumorderived vascular endothelial growth factor (VEGF) overproduction leading to systemic immune polarization to a state of CD4 cell Th2 bias.5 Consequently, we sought to determine if similar differen...

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“…2,[4][5][6][7] The poor prognosis in our patient might be due to the poor prognostic factors such as presence of ulceration, Breslow thickness of 11 mm, sentinel and regional lymph node metastasis, presence of perineural invasion and mitotic index as 1/mm 2 . 8,9 Although the location of melanoma is not currently considered as a prognostic factor, the nipple region can easily be neglected during routine physical examination, and it has a delicate lymphatic circulation, which could impair the prognosis when seen as a rapid thickening of the melanoma within a short time period, as in our case. 8,9 In the previous reports, there is no data about the molecular analysis of the nipple melanomas.…”

Section: Discussionmentioning

confidence: 87%

“…8,9 Although the location of melanoma is not currently considered as a prognostic factor, the nipple region can easily be neglected during routine physical examination, and it has a delicate lymphatic circulation, which could impair the prognosis when seen as a rapid thickening of the melanoma within a short time period, as in our case. 8,9 In the previous reports, there is no data about the molecular analysis of the nipple melanomas. We found BRAF exon 15 V600E mutation to be negative in our case.…”

Section: Discussionmentioning

confidence: 87%

A Rare Variant of Braf Negative Melanoma Originating from Nipple with Comparison of the Literature Data: Case Report

Duman¹,

Erkin²,

Gököz³

et al. 2015

Turkiye Klinikleri J Dermatol

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Melanoma

Cited by 137 publications

References 89 publications

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients – An EORTC Melanoma Group study

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients – An EORTC Melanoma Group study

Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis

A Rare Variant of Braf Negative Melanoma Originating from Nipple with Comparison of the Literature Data: Case Report

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