Melanoma Maligno Cutâneo: Estudo Retrospetivo de Sete Anos (2006-2012)

Abstract

Acta Med Port 2014 Jul-Aug;27(4):480-488 RESUMOIntrodução: O melanoma maligno é a neoplasia cutânea mais agressiva, e a sua incidência tem vindo a aumentar nas últimas déca-das. A possibilidade de cura depende de um diagnóstico atempado, sendo fundamental o conhecimento da sua epidemiologia para a implementação de programas de prevenção primária e deteção precoce do melanoma. ABSTRACTIntroduction: Malignant melanoma is the most aggressive skin cancer and its incidence has been increasing in recent decades. The cure depends on early diagnosis and understanding melanoma epidemiology is of great importance for the implementation of programs of primary prevention and early detection. Material and Methods:We reviewed the clinical cases of primary cutaneous malignant melanoma diagnosed between January 2006 and December 2012 at Centro Hospitalar de São João, in Porto.Results: An overall of 148 cases of melanoma were analyzed and a female predominance was observed (ratio F:M -1.6:1). The average age at diagnosis was 61 years. The locations most frequently affected were the lower limbs and trunk. In males the back was the most frequently involved, while in females the lesions occurred preferentially in the legs. Superficial spreading melanoma prevailed in almost all age groups. There was a predominance of thin melanomas and the mitotic index was intermediate (1-6 mitoses/ mm 2 ) in most patients. The ulceration was present in 22.3% of cases and prevailed in thick melanomas as well in nodular subtype. Most patients present at stage IA. There was progression to metastatic disease in 20 patients. Discussion: The profile of patients with cutaneous melanoma in Centro Hospitalar de São João has characteristics relatively similar to those described in the literature. Conclusion: The prevalence of thin melanomas, generally with a better outcome, is probably the result of an earlier detection.

Population-based Study of Cutaneous Malignant Melanoma in the South Region of Portugal: Epidemiological and Clinical Characterization (2016-2017)

“…The location of the primary tumour identi ed in this study and its distribution by gender is as expected by previous research and possibly explained by behaviour of sun exposure adopted by men and women (19) (1) (2) (20). Previous national studies have also reported differences in the location of the primary tumour by gender (21).…”

“…Notwithstanding, the data also suggests that most cases are diagnosed at early stages, as described in Portugal and also in Sweden ( 17) (21).…”

Epidemiological and clinical characterization of a population-based cohort of cutaneous malignant melanoma patients in the South Region of Portugal

“…Notwithstanding, the data also suggests that most cases are diagnosed at early stages, as described in Portugal and also in Sweden 17,23 .…”

“…The location of the primary tumour identified in this study and its distribution by sex is as expected by previous research and possibly explained by behaviour of sun exposure adopted by men and women 1,2,21,22 . Previous national studies have also reported differences in the location of the primary tumour by sex 23 . Our study has not identified sex as a prognostic factor, contradicting previous research, which has also suggested differential improvements over time, where prognosis of males seem to have improved more due to disparities in instituted treatments 24 .…”