Melanoma metastatic to the hyoid bone

Ryan, John F.; Xie, Deborah X.; Eytan, Danielle F.; McCarthy, Edward F.; Mandal, Rajarsi; Gourin, Christine G.; Lipson, Evan J.; Meyer, Christian F.; Vosler, Peter S.

doi:10.1002/ccr3.3571

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Other causes of both cervical lymphadenopathy and dysphagia, like lymphoma, high esophageal cancer or other head and neck cancers, can considered in the differential diagnosis. In the literature, there are a few cases of hyoid bone metastasis from distal malignant tumors, such as breast cancer, renal cell carcinoma, lung adenocarcinoma, melanoma and hepatocellular carcinoma [2][3][4][5][6]. Lung adenocarcinoma is more prone to vascular invasion and distant metastasis than squamous carcinoma [5].…”

Section: Discussionmentioning

confidence: 99%

“…Lung adenocarcinoma can also metastasize to the hyoid through the circulatory system, in particular, through the branch of the superior laryngeal artery. Any patient with a hyoid tumor and a previous history of melanoma should be considered in the differential diagnosis for metastatic melanoma [6]. Melanoma frequently metastasizes to cervical lymph nodes in the head and neck; bone metastases are observed in 11-17% of patients and usually occur in the axial skeleton [6].…”

Section: Discussionmentioning

confidence: 99%

“…Any patient with a hyoid tumor and a previous history of melanoma should be considered in the differential diagnosis for metastatic melanoma [6]. Melanoma frequently metastasizes to cervical lymph nodes in the head and neck; bone metastases are observed in 11-17% of patients and usually occur in the axial skeleton [6]. The hyoid bone is also reported as a rare site of metastases in patients with renal cell carcinoma (RCC) [10] and in patients with rare lymphoproliferative disorders like solitary plasmacytoma (SP) and unicentric Castleman disease (UCD), characterized by a single set of locally enlarged lymph nodes [11].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are few cases of hyoid bone metastasis from distal primary malignant tumors, such as renal cell carcinoma, breast cancer and liver carcinoma [2][3][4]. Hyoid bone metastasis from lung adenocarcinoma [5], melanoma [6] and sigmoid adenocarcinoma [7] are also reported in the literature but are exceedingly rare.…”

Section: Introductionmentioning

confidence: 99%

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Hyoid Bone Metastases: An Unusual Case

Di Marco,

Tucci,

Iacomino

et al. 2023

Reports

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(1) Background: Secondary tumors of the hyoid bone are extremely rare in clinics. In the literature, there is only one study about hyoid bone metastases from sigmoid adenocarcinoma. (2) Methods: We report a case of hyoid bone metastases in a 78-year-old patient treated for rectum and sigmoid colon adenocarcinoma. (3) Results: A mass excision surgery of a rounded osteolytic mass of 4.5 × 3.6 cm in size in the central part of the hyoid bone was performed under general anesthesia, according to the multidisciplinary tumor board recommendation. (4) Conclusions: Hyoid bone metastases can occur in the rectum and sigmoid colon adenocarcinoma. A total body bone scintigraphy and CT examination are suggested to detect silent bone metastases in patients with a history of cancer and neck masses. The prognosis is good, but a regular follow-up is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyoid Bone Metastases: An Unusual Case

Di Marco,

Tucci,

Iacomino

et al. 2023

Reports

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Swellings of the Hyoid Bone Region

Sakr

2024

Midline Neck Swellings

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Radiotherapy for hyoid bone metastasis from lung adenocarcinoma: A case report

Hsu,

Hribar,

Poen

2024

World J Clin Oncol

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BACKGROUND Metastasis to the hyoid bone is an exceptionally rare occurrence, with documented cases limited to breast, liver, colon, skin, lung, and prostate cancers. This report highlights an unusual case involving the metastasis of lung adenocarcinoma to the hyoid bone, accompanied by a distinctive headache. Previous documentation involved surgical resection of the hyoid mass. We present a case displaying the benefits of palliative radiotherapy. CASE SUMMARY A 72-year-old non-smoking, non-alcoholic woman, initially under investigation for a year-long elevation in absolute lymphocyte count, presented with a month-long history of intermittent throat pain. Despite negative findings in gastroenterological and otolaryngologic examinations, a contrast-enhanced chest computed tomography scan revealed a mediastinal mass and questionable soft tissue thickening in her left anterolateral neck. Subsequent imaging and biopsies confirmed the presence of lung adenocarcinoma metastasis to the hyoid bone. The patient was treated with platinum-based chemo-immunotherapy along with pembrolizumab. Ultimately, the lung cancer was unresponsive. Our patient opted for palliative radiation therapy instead of surgical resection to address her throat pain. As a result, her throat pain was alleviated, and it also incidentally resolved her chronic headaches. This is the second documented case of lung adenocarcinoma metastasizing to the hyoid bone. CONCLUSION Palliative radiotherapy may add to the quality of life in symptomatic patients with cancer metastatic to the hyoid bone.

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Melanoma metastatic to the hyoid bone

Abstract: Metastatic melanoma may be included in the differential diagnosis of hyoid masses in patients with a history of melanoma. Hyoid resection is well tolerated and of diagnostic and therapeutic benefit in patients with tumors metastatic to the hyoid bone.

Cited by 3 publications

References 4 publications

Hyoid Bone Metastases: An Unusual Case

Hyoid Bone Metastases: An Unusual Case

Swellings of the Hyoid Bone Region

Radiotherapy for hyoid bone metastasis from lung adenocarcinoma: A case report

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