Melanoma mimicking atypical fibroxanthoma: Report of an unusual case

Abstract

Melanoma may mimic a variety of skin lesions clinically and histopathologically, and presents diagnostic challenges. In this article, we describe a case of melanoma in an 89-year-old man with a very rare histopathologic presentation, namely the presence of pleomorphic and multinucleated giant cells with abundant cytoplasm, highly resembling an atypical fibroxanthoma. The differential diagnoses in conjunction with the findings in immunohistochemical study are also discussed.

Hemosiderotic (pigmented) atypical fibroxanthoma mimicking malignant melanoma

“…The pigmented or hemosiderotic variants of atypical fibroxanthoma have been rarely described in the literature [3][4][5]. Rarely, melanoma can histologically mimic atypical fibroxanthoma [6]. Interestingly atypical fibroxanthoma within a malignant melanoma has been reported [7].…”