Melanoma of the gallbladder: appropriate surgical management and review of the literature

Christou, Demetris; Katodritis, Nicos; Decatris, Marios P.; Katodritou, Angela; Michaelides, Ioannis; Nicolaou, Nicoletta; Kounoushis, Michalis; Hadjicostas, Panayiotis T.

doi:10.1002/ccr3.121

Cited by 23 publications

(27 citation statements)

References 23 publications

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“…One promising avenue for the future in the treatment of metastatic melanoma is chemoimmunotherapy. One study documented the use of high-dose interleukin-2 in tumor remission in approximately 15% of patients [ 18 ]. However, the use of interleukin-2 is limited on a large scale due to toxicity and difficulties with its administration.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Melanoma of the Gallbladder in an Asymptomatic Patient

Khan

Patel

Zaccarini

et al. 2017

Case Reports in Gastrointestinal Medicine

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Malignant Melanoma (MM) is among the most dangerous malignancies with some of the least known survival rates. Melanoma most commonly metastasizes to regional lymph nodes, the lungs, and brain. Metastatic disease of the gallbladder (GB) is exceptionally rare making it difficult to diagnose. The fact that typically patients do not present until they are symptomatic—only after widespread metastatic disease has already occurred—is further complicating the diagnosis of MM of the GB. For this reason, MM of the GB is rarely discovered in living patients. In fact, review of the literature showed only 40 instances in which metastatic disease of the GB was reported in living patients. We describe the presentation and management of a patient who had metastatic disease of the GB. However, our case is unique because his malignancy was discovered incidentally while he was asymptomatic. He was successfully treated with an open cholecystectomy. We have presented this case in order to make the necessity of meticulous investigation of potential metastasis in patients with a known history of cutaneous melanoma clear.

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Section: Discussionmentioning

confidence: 99%

Metastatic Melanoma of the Gallbladder in an Asymptomatic Patient

Khan

Patel

Zaccarini

et al. 2017

Case Reports in Gastrointestinal Medicine

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“…Melanocytes are a dendritic-type cell, which provides melanin to keratinocytes and can be found in most organ viscera, depending on neural crest migration during embryogenesis [ 1 , 8 ]. Melanoma is a malignant tumor of melanocytes and represents <5% of all skin cancers [ 5 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Cutaneous Melanoma of the Gallbladder

Patel

Sohrawardy

Sedhai

et al. 2017

Case Reports in Gastrointestinal Medicine

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Metastatic melanoma is an aggressive disease that can spread to many organs of the body. In rare cases, it can spread to the gallbladder causing secondary lesions, yet presenting with little to no symptoms. Therefore, most cases of metastatic melanoma lesions to the gallbladder go undiagnosed. Here, we present the case of a 41-year-old male with a four-month history of melanoma of the face, with a postresection status, who presented with right upper quadrant abdominal pain. Doppler ultrasound and computed tomography confirmed the presence of a mass on the gallbladder. Laparoscopic excision along with liver wedge resection was performed. Pathology staining revealed the presence of a malignant metastatic melanoma lesion of the gallbladder.

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“…A very recent paper, on the contrary, encourages an open surgical approach rather than laparoscopic in order to avoid trocar recurrence and to detect other gastrointestinal metastases undetected preoperatively [28]. However, the main risks related to LC (perforation of the gallbladder and intra-abdominal bile leak and/or port sites) could be prevented with gentle dissection and use of the endobag [20,25].…”

Section: Discussionmentioning

confidence: 99%

Metastatic melanoma of the gallbladder: report of two cases and a review of the literature

et al. 2015

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Melanoma is one of the most aggressive and highly metastatic cancers. The most common sites of distant metastases are soft tissues, lung, liver, skin and brain, whereas only few patients develop gastrointestinal metastases. Metastatic involvement of the gallbladder is rare and more often part of a widespread disease than a solitary lesion. The "gold-standard" treatment of metastatic melanoma of the gallbladder remains unclear. We report two cases of patients with past history of cutaneous melanoma who developed visceral metastases. The first patient was asymptomatic and had a widespread disease with metastatic involvement of both the spleen and the gallbladder. The second patient had an isolated metastasis of the gallbladder and complained of upper abdominal pain. The chosen treatment was open cholecystectomy (and splenectomy) in the first case and laparoscopic cholecystectomy in the second. A review of the literature is provided.

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Melanoma of the gallbladder: appropriate surgical management and review of the literature

Cited by 23 publications

References 23 publications

Metastatic Melanoma of the Gallbladder in an Asymptomatic Patient

Metastatic Melanoma of the Gallbladder in an Asymptomatic Patient

Metastatic Cutaneous Melanoma of the Gallbladder

Metastatic melanoma of the gallbladder: report of two cases and a review of the literature

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