Melanoma-related changes in skin microbiome

Mrázek, Jakub; Mekadim, Chahrazed; Kučerová, Petra; Švejstil, Roman; Salmonová, Hana; Vlasáková, Jitka; Tarasová, Renata; Čížková, Jana; Červinková, Monika

doi:10.1007/s12223-018-00670-3

Cited by 60 publications

(61 citation statements)

References 46 publications

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“…Canine Mast Cell Tumor (MCT) arises from an uncontrolled proliferation of neoplastic mast cells in cutaneous and subcutaneous tissues and is one of the most common skin neoplasms in dogs, accounting for up to 21% of all skin tumours 16 . The alterations of the microbiota of epidermal surface and its relationship with tumors have been investigated in humans and in experimental animals 17 , 18 . The onset of MCT and the presence of a high number of mast cells, the degranulation of which triggers a release of histamine, heparin and proteases, collectively defined as Darier’s signs 19 , could lead to changes in microbiota at both skin surface and dermis level.…”

Section: Introductionmentioning

confidence: 99%

Characterization of skin surface and dermal microbiota in dogs with mast cell tumor

Zamarian

Catozzi

Cuscó³

et al. 2020

Sci Rep

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The skin microbiota interacts with the host immune response to maintain the homeostasis. Changes in the skin microbiota are linked to the onset and the progression of several diseases, including tumors. We characterized the skin surface and dermal microbiota of 11 dogs affected by spontaneous mast cell tumor (MCT), using skin contralateral sites as intra-animal healthy controls. The microbial profile differed between healthy and tumor skin surfaces and dermis, demonstrating that the change in microbiota composition is related to the presence of MCT. The number of observed taxa between MCT and healthy skin surfaces was detected, showing a decrease in number and heterogeneity of taxa over the skin surface of MCT, at both inter-and intra-individual level. Preliminary data on bacterial population of MCT dermis, obtained only on three dogs, demonstrated an intra-individual reduction of taxa number when compared to the skin surface. Taxonomy reveals an increase of Firmicutes phylum and Corynebacteriaceae family in MCT skin surface when compared to the healthy contralateral. In conclusion, we demonstrate that microbial population of skin surface and dermis is related to mast cell tumor. Our study provides the basis for future investigations aiming to better define the interaction between mast cell tumors, microbiota and host immune response. The epidermis, or skin surface, provides the external layer to the three parts of the skin, the inner layer being the dermis and hypodermis. The epidermis is regarded as a microenvironment containing a rich eukaryotic and prokaryotic population, currently defined as the microbiota 1,2 , which plays a role as protective and immunological barrier 3. Culture-independent determination of the microbial profile of dog skin surface has been recently determined, showing that microbiota largely differs between body sites 4. The skin microbiota is modulated by extrinsic (e.g. diet, environment) and intrinsic (e.g. genetics) factors 5 , and is not only limited to skin surface but also extends to the dermis 6. Remarkably, bacteria detected within the human healthy dermis and subcutaneous adipose tissue showed a different microbial population profile as compared to the skin surface 7. Four major phyla-namely Actinobacteria, Firmicutes, Proteobacteria, Bacteroidetes-and four major families-namely Corynebacteriaceae, Propionibacteriaceae, Staphylococcaceae, Micrococcaceae-dominate both canine 2 and human epidermal surfaces 1. Given the limited number of studies, the definition of canine skin "healthy microbiota" is still debated. Changes in microbiota composition are associated with the development of skin disorders in both humans and dogs 8,9 , as previously reported dermatitis 10 in dogs. The defensive capability of skin is supported by healthy and balanced microbiota through the interaction with the residing immune cells in the cutis 9,11,12. Due to their localization within the skin, mast cells are in close contact with the bacterial population 13. The activities of mast cells may be amplified...

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Section: Introductionmentioning

confidence: 99%

Characterization of skin surface and dermal microbiota in dogs with mast cell tumor

Zamarian

Catozzi

Cuscó³

et al. 2020

Sci Rep

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“…Therefore, periodontitis might affect the long-term HM risk through autoimmune response or chronic inflammation [41]. Regarding the relevance of periodontitis and cutaneous melanoma, it was discovered that the microbiome (including gut microbiome, oral microbiome and skin microbiome) had a significant impact on the development and immunotherapy of cutaneous melanoma [42][43][44]. It was speculated that periodontitis might affect the balance of human microbiome and promote the development of melanoma.…”

Section: Discussionmentioning

confidence: 99%

Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population

Ma¹,

Zheng²,

Li³

2020

Int. J. Med. Sci.

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Background: Some studies have reported biological linkages between periodontitis and esophageal cancer, prostate cancer, kidney cancer, hematological malignancy, and melanoma of the skin. This meta-analysis aimed to assess the relationship between periodontitis and the aforementioned five cancers. Methods: Eligible studies on the association between periodontitis and the aforementioned five kinds of cancers were retrieved. The statistical analysis was conducted using Stata 12.0. Results: Ten articles (more than 100,000 samples for most cancers) were included. With statistical significance, participants with periodontitis might have enhanced risks of esophageal cancer (

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“…Dysbiosis of microbiota may result in cancers such as lung cancer (mainly due to dysbiosis of airway and lung microbiota) [483], melanoma (due to dysbiosis of skin microbiota) [484], cancers of the urogenital system (due to dysbiosis of urinary tract microbiota) [485,486], and breast cancer (due to dysbiosis of breast tissue microbiota) [487].…”

Section: Cancers Of Digestive Systemmentioning

confidence: 99%

Human Gut Microbiota: Friend or Foe?

Pliszka¹,

Szablewski²

2020

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The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Similarly, human health depends on the composition of gut microbiome, with gut bacteria playing a crucial role in human physiology. For instance, gut microbiota synthesizes vitamins and amino acids, and affects the biotransformation of bile acid. Intestinal microbiota produces short-chain fatty acids (SCFAs) that stimulate intestinal gluconeogenesis, protect the host from diet-induced obesity, and may play a role as an energy substrate. Changes in the composition of gut microbiota, termed dysbiosis, due to, for example, change in the diet or uptake of certain drugs, may result in metabolic diseases, autoimmune and allergic diseases, cancers, and many others. Conversely, dysbiosis can be a consequence of a disease in several cases. This review outlines the current knowledge of the associations between human gut microbiota and human health and diseases.

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Melanoma-related changes in skin microbiome

Cited by 60 publications

References 46 publications

Characterization of skin surface and dermal microbiota in dogs with mast cell tumor

Characterization of skin surface and dermal microbiota in dogs with mast cell tumor

Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population

Human Gut Microbiota: Friend or Foe?

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