Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients

Haanen, John B.A.G.; Baars, Arnold; Gomez, Raquel; Weder, Pauline; Smits, M.; Gruijl, Tanja D. de; Blomberg, B. Mary E. von; Bloemena, Elisabeth; Scheper, Rik J.; Ham, S. Marieke van; Pinedo, H. M.; Eertwegh, Alfons J.M. van den

doi:10.1007/s00262-005-0018-5

Cited by 132 publications

(88 citation statements)

References 27 publications

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“…However, numerous studies on colorectal [9], ovarian [10], breast [11,12], and esophageal cancer [13], leukemia [14], and other malignancies confirmed the protective prognosis value of the immune infiltrate with CD8+ T lymphocytes [15]. Nevertheless, there are conflicting results, such as in melanoma, where TILs influence survival either positively [16,17] or negatively [18,19].…”

Section: Introductionmentioning

confidence: 95%

Comparative analysis of CD4 and CD8 lymphocytes — evidences for different distribution in primary and secondary liver tumors

Giuşcă

Wierzbicki

Amălinei

et al. 2015

Folia Histochem Cytobiol.

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Introduction. The impact of tumor cells on tumor-infiltrating lymphocytes (TILs) in cancer developmentis not yet clarified. Our study analyzed the distribution and prognostic value of CD4+ and CD8+ T lymphocytes in hepatocellular carcinoma (HCC) and liver metastases (LM). Material and methods. Archival tissue specimens of 35 HCC and 39 LM patients were immunohistochemically processed. The number of intratumoral (IT) and peritumoral (PT) CD4+ and CD8+ T cells was quantitatively analyzed. Results.We noted large variances of T lymphocyte subpopulations. Similar number of CD4+ and CD8+ lymphocytes was present in HCC, whereas in LM the number of CD8+ cells was approximately two times higher than CD4+ lymphocytes. A significant prevalence of T cells in PT over IT areas was observed. The prognostic value was demonstrated only for PT CD8+ lymphocytes in LM, their reduced number being associated with shorter survival. Conclusions. The differences between proportions of T lymphocytes within tumor and its environment might be explained by proapoptotic effect of cancer cells on TILs.

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Section: Introductionmentioning

confidence: 95%

Comparative analysis of CD4 and CD8 lymphocytes — evidences for different distribution in primary and secondary liver tumors

Giuşcă

Wierzbicki

Amălinei

et al. 2015

Folia Histochem Cytobiol.

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“…Tumor infiltration by CTL or by T, NK, and NKT cells is associated with favorable prognosis in different neoplasias such as melanoma, colon, and ovarian carcinomas [16][17][18]. On the other side unefficient activation of iDC in pancreatic carcinoma [19], induction of T-cell anergy mediated by APC cells [20], or altered DC infiltration pattern along the colorectal adenoma-carcinoma sequence [21] are examples how tumors avoid immune recognition.…”

Section: Discussionmentioning

confidence: 99%

BioBran-augmented maturation of human monocyte-derived dendritic cells

Cholujová¹,

Jakubíková²,

Sedlák³

2009

neo

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BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). Immature DC (iDC) derived from plastic-adhered, IL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix 1 (CMM1; TNF-α, IL-1β and IL-6) or CMM2 (LPS and IFN-γ) to induce their maturation into mature DC (matDC1 or matDC2, respectively). Different concentrations of BioBran (10, 100, 400 and 1000 μg/ml) were applied in the presence or absence of relevant CMM to assess the effects of BioBran on DC maturation processes. BioBran induced maturation of iDC, as these cells cultured with IL-4/GM-CSF/BioBran down-regulated CD14 and CD1a antigens on cell surface and significantly increased expression of maturation marker CD83. The increase of surface density of costimulatory molecules CD80 and CD86 on iDC in the presence of BioBran was also observed. In addition, BioBran induced functional maturation of iDC, confirmed by decreased endocytic activity of iDC. Furtheremore, BioBran enhanced maturation potential of cytokine mixes, as both matDC1 and matDC2 exposed to BioBran completely lost CD14 and upregulated CD83, CD80 and CD86 antigens, in comparison to DC matured with the relevant CMM alone. BioBran also increased CD123 antigen expression on all DC subsets. Interestingly, matDC2 matured in the presence of BioBran (400μg/ml) expressed higher levels of CD123 and lower levels of CD11c cell surface antigens, the phenotype represented by CD11c dim CD123bright plasmacytoid DC population. These data demonstrate that BioBran is a potent enhancer of DC maturation and suggest that BioBran might be a useful agent to create the environment that favours DC maturation.

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“…However, when correlating LC and pT level separately in ulcerated and non-ulcerated tumors, we have identified their presence in thinner tumors. Presence of LC within the tumor is associated with factors of better prognosis (thinner tumors), most likely these cells being involved in antitumor host defense by presenting antigens to CD8(+) cells 49 . The maturation state of DCs in cutaneous melanoma can be prognosticator biomarker in this disease.…”

Section: Cells That Sustain the Inflammatory Milieumentioning

confidence: 99%

“…High levels of MDSC were also associated with the absence of T lymphocytes specific for melanoma derived antigens (especially NY-ESO-1 or Melan-A) identified in the peripheral blood of long-term survivors 73 . We can draw some circulatory immune cells outlines, and one conclusion is that there is no perfect match between circulating immune cells and tumor associated ones, an already acknowledged discrepancy 74 . Another important issue is that circulating immune cell's phenotype particularities is delicately linked to the stage melanoma is diagnosed in, and that, only the mere broad immune cell population cannot clearly depict the disease evolution.…”

Section: Cd11bmentioning

confidence: 99%