Melanoma to the Heart

Durham, Charis; Hall, James A.; Fidone, Erica; Mack, Ryan; Metting, Austin

doi:10.1080/08998280.2016.11929500

Cited by 4 publications

(11 citation statements)

References 10 publications

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“…Regarding benign neoplasms, myxomas and lipomas are the most prevalent [1]. e heart and pericardium are often affected in the context of disseminated metastatic tumour [1,[4][5][6]. Secondary cardiac metastasis is found in 20% of autopsies and approximately 10% of metastatic cancer patients [1,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…e heart and pericardium are often affected in the context of disseminated metastatic tumour [1,[4][5][6]. Secondary cardiac metastasis is found in 20% of autopsies and approximately 10% of metastatic cancer patients [1,[4][5][6]. Any cardiac structure may be metastasized, but the epicardium is the preferred site, as described in 75.5% of the cases, and at least half of these are accompanied by pericardial effusion [1,7].…”

Section: Introductionmentioning

confidence: 99%

“…e main forms of neoplastic dissemination are essentially by lymphatic route, hematogenous route, and contiguous extension [1,7]. e main malignancies with frequent cardiac involvement are the lung and breast cancers, mainly due to their anatomical proximity and high prevalence [1,2,6,7]. Nonepithelial tumours have cardiac involvement in 22.7% of cases [2].…”

Section: Introductionmentioning

confidence: 99%

“…The main malignancies with frequent cardiac involvement are the lung and breast cancers, mainly due to their anatomical proximity and high prevalence [ 1 , 2 , 6 , 7 ]. Nonepithelial tumours have cardiac involvement in 22.7% of cases [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cardiac tamponade as the first manifestation of neoplasia is unlikely since, in addition to pericardial infiltration by malignant cells, the presence of other circumstances, such as an acute event or even lymphatic obstruction, is necessary [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Heart Dissemination: A Clinical Case of Melanoma

André

Gouveia

et al. 2021

Case Reports in Medicine

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Introduction. Primitive malignant heart tumours are rare, specific cases. The presence of cardiac metastases, often in the pericardium, besides indicating disseminated oncological disease, represents a diagnostic challenge since they tend to be asymptomatic. Malignant cutaneous melanoma (MCM) is the neoplasm that most often affects the heart. Patients and Methods. The authors describe a case report of a 59-year-old female patient with a history of non-insulin-treated diabetes mellitus, arterial hypertension, dyslipidemia, and remitting cutaneous malignant melanoma who underwent skin excision, lymphadenectomy, and adjuvant chemotherapy in 1996. In April 2014, she resorted to emergency service due to epigastric pain and progressive tiredness. Due to the persistence of the complaints, abdominal ultrasound was performed, which showed a large pericardial effusion, corroborated later by teleradiography and echocardiography. The patient underwent pericardiocentesis, which isolated neoplastic cells. A computed tomography study of the chest, abdomen, and pelvis revealed bilateral and pericardial pleural effusion, as well as alterations suggestive of pericardial and pulmonary metastasis. Later, fine-needle aspiration puncture of the left posterior cervical nodule confirmed histologically malignant melanoma metastasis. Discussion. Given the natural history of melanoma that when metastasized has an overall survival of 15–20% for 5 years, its metastatic spread may occur several years after its surgical excision. Thus, patients with a history of melanoma and heart failure who develop new cardiac symptoms of unknown aetiology should undergo imaging studies such as echocardiography, computed tomography, and magnetic resonance imaging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heart Dissemination: A Clinical Case of Melanoma

André

Gouveia

et al. 2021

Case Reports in Medicine

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Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes

et al. 2022

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Background Cardiac metastasis of melanoma is rare and typically diagnosed post‐mortem. Here we perform a retrospective cohort study and systematic review of patients with metastatic melanoma to characterize prevalence, clinical characteristics, and outcomes of cardiac metastasis. Methods We reviewed the electronic medical records of all outpatients with metastatic melanoma who underwent evaluation at the University of Michigan in Ann Arbor from January 2009 to January 2022, identifying patients with a clinical or histopathologic diagnosis of cardiac metastasis. We performed a systematic review of the literature to summarize the clinical characteristics and outcomes of patients with melanoma and cardiac metastasis. Results Overall, 23 of 1254 (1.8%) patients with metastatic melanoma were diagnosed with cardiac metastasis. Cardiac metastasis was reported in the right ventricle (65%), left ventricle (35%), and right atrium (35%). A total of 11 (48%) patients experienced at least one cardiovascular complication after the diagnosis of cardiac metastasis, the most common being arrhythmia (30%), heart failure (22%), and pericardial effusion (17%). Immunotherapy was more commonly used in patients with cardiac metastasis (80% vs 65%; p = 0.005). Mortality at 2‐years post‐diagnosis was higher for patients with cardiac metastasis compared to those without (59% vs 37%; p = 0.034). Progression of malignancy was the underlying cause of death of all patients. Conclusions Cardiac metastasis occurs in <2% of patients with metastatic melanoma, can affect all cardiac structures, and is associated with various cardiovascular complications and high mortality.

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